The study evaluated the impact of film on the knowledge of sickle cell disease (SCD) in the Obio-Akpor Local Government Area of Rivers State, Nigeria. The objective of the study was to find out the level that sickle cell-themed movies have helped increase respondents’ knowledge and attitudes towards sickle cell disease, and how respondents perceive the effectiveness of movies as a means of increasing their knowledge and understanding of sickle cell disease. The study was conducted using a survey design. The population of the study was 683,565. A sample size of 400 was obtained from the population size using the Taro Yamane formula and three selected communities were sampled. A purposive sampling technique was used to draw advocates and relatives of sickle cell disease for an online interview. The result of the analysis showed that sickle cell-themed films have not been effective in campaigning against sickle cell disease as there has been low awareness about the symptoms and treatment options of sickle cell disease even with film campaigns. However, movies have helped respondents understand the emotional and social impact of sickle cell disease on individuals and families. Also, while four out of the seven factors had a mean below the criterion mean of 2.50, the aggregate was above the criterion mean. To achieve effectiveness, it was recommended that community leaders and the government should fund and encourage filmmakers to create more health advocacy campaigns and sponsor more sickle cell-themed movies.