In this work, we investigate a class of nonlocal integro-differential equations involving Hilfer fractional derivatives and almost sectorial operators. We prove our results by applying Schauder’s fixed point technique. Moreover, we show the fundamental properties of the representation of the solution by discussing two cases related to the associated semigroup. For that, we consider compactness and noncompactness properties, respectively. Furthermore, an example is given to illustrate the obtained theory.