Abstract. The Möbius polynomial is an invariant of ranked posets, closely related to the Möbius function. In this paper, we study the Möbius polynomial of face posets of convex polytopes. We present formulas for computing the Möbius polynomial of the face poset of a pyramid or a prism over an existing polytope, or of the gluing of two or more polytopes in terms of the Möbius polynomials of the original polytopes. We also present general formulas for calculating Möbius polynomials of face posets of simplicial polytopes and of Eulerian posets in terms of their f -vectors and some additional constraints.