Highs and Lows in the Calicivirus Reverse Genetics
Ángel L. Álvarez,
Aroa Arboleya,
Fábio A. Abade dos Santos
et al.
Abstract:In Virology, the term reverse genetics refers to a set of methodologies in which changes are introduced into the viral genome and their effects on the generation of infectious viral progeny and their phenotypic features are assessed. Reverse genetics emerged thanks to advances in recombinant DNA technology which made the isolation, cloning, and modification of genes through mutagenesis possible. Most virus reverse genetics studies depend on our capacity to rescue an infectious wild-type virus progeny from cell… Show more
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