Highly Wrinkled Cross‐Linked Graphene Oxide Membranes for Biological and Charge‐Storage Applications

Tang, Lena Ai Ling; Lee, Wong Cheng; Shi, Hui; Wong, Ethel Y. L.; Sadovoy, Anton; Gorelik, Sergey; Hobley, Jonathan; Lim, Chwee Teck; Loh, Kian Ping

doi:10.1002/smll.201101690

Cited by 112 publications

(88 citation statements)

References 43 publications

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“…By searching the literature, we found that many other nanoparticles produced wrinkles on GO as well. 13,[30][31][32][33][34] Our own experiment also indicated that silica nanoparticles can produce very obvious wrinkling ( Figure S2A). On the other hand, if GO is dried by itself, no extensive wrinkling was observed ( Figure 2F).…”

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confidence: 71%

Evaporation induced wrinkling of graphene oxide at the nanoparticle interface

Wang

Liu

2015

Nanoscale

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With the thickness of only a single atomic layer, graphene displays many interesting surface properties. A general observation is that wrinkles are formed on graphene oxide (GO) when it is dried in the presence of adsorbed inorganic nanoparticles. In this case, evaporation induced wrinkling is not an elastic deformation but is permanent. Understanding the nanoscale force of wrinkle formation is important for device fabrication and sensing. Herein, we employ surface functionalized gold nanoparticles (AuNPs) as a model system. All tested AuNPs induced wrinkling, including those capped by DNA, polymers and proteins. The size of AuNPs is less important compared to the property of solvent. Wrinkle formation is attributed to drying related capillary force acting on the GO surface, and a quantitative equation is derived. After drying, the adsorption affinity between GO and AuNPs is increased due to increased contact area.

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confidence: 71%

Evaporation induced wrinkling of graphene oxide at the nanoparticle interface

Wang

Liu

2015

Nanoscale

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“…63 The XRD pattern of GO showed a strong peak located in the low-angle region (approximately 10.8°), which is similar to those of other GO precursors. 31,63 Gt oxidation involves the insertion of oxygen-containing groups, mainly carboxylic acid at the periphery and epoxide and hydroxyl groups between the planes, which leads to an increase in d-spacing to 7.8 Å with the diffraction peak at 2θ =10.8° (Figure 2A). This peak completely disappeared after resveratrol treatment, and a new peak at 2θ =25.9° emerged due to graphene diffraction.…”

Section: Xrd Analysis Of Go and Res-rgomentioning

confidence: 99%

“…6,7,26 The most commonly used chemical-reducing agents are hydrous hydrazine, hydrazine monohydrate, sodium borohydride, and hydrogen sulfide, which are highly toxic and harmful to living organisms and the environment. 6,9,[26][27][28] To overcome the aggregation and solubility problems, several polymers or surfactants have been used such as poly(sodium-4-styrenesulfonate), 29 alkaline conditions, 30 poly(N-vinyl-2-pyrrolidone), 31 and poly(allylamine). 32 Recently, biological molecules have been used to reduce GO; thus, Salas et al 33 have reported "green" reduction of GO via bacterial respiration.…”

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confidence: 99%

Reduction of graphene oxide by resveratrol: a novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule

Gurunathan¹,

Han²,

Kim³

et al. 2015

IJN

148

129

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Objective Graphene represents a monolayer or a few layers of sp 2 -bonded carbon atoms with a honeycomb lattice structure. Unique physical, chemical, and biological properties of graphene have attracted great interest in various fields including electronics, energy, material industry, and medicine, where it is used for tissue engineering and scaffolding, drug delivery, and as an antibacterial and anticancer agent. However, graphene cytotoxicity for ovarian cancer cells is still not fully investigated. The objective of this study was to synthesize graphene using a natural polyphenol compound resveratrol and to investigate its toxicity for ovarian cancer cells. Methods The successful reduction of graphene oxide (GO) to graphene was confirmed by UV-vis and Fourier transform infrared spectroscopy. Dynamic light scattering and scanning electron microscopy were employed to evaluate particle size and surface morphology of GO and resveratrol-reduced GO (RES-rGO). Raman spectroscopy was used to determine the removal of oxygen-containing functional groups from GO surface and to ensure the formation of graphene. We also performed a comprehensive analysis of GO and RES-rGO cytotoxicity by examining the morphology, viability, membrane integrity, activation of caspase-3, apoptosis, and alkaline phosphatase activity of ovarian cancer cells. Results The results also show that resveratrol effectively reduced GO to graphene and the properties of RES-rGO nanosheets were comparable to those of chemically reduced graphene. Biological experiments showed that GO and RES-rGO caused a dose-dependent membrane leakage and oxidative stress in cancer cells, and reduced their viability via apoptosis confirmed by the upregulation of apoptosis executioner caspase-3. Conclusion Our data demonstrate a single, simple green approach for the synthesis of highly water-dispersible functionalized graphene nanosheets, suggesting a possibility of replacing toxic hydrazine by a natural and safe phenolic compound resveratrol, which has similar efficacy in the reduction of GO to rGO. Resveratrol-based GO reduction would facilitate large-scale production of graphene-based materials for the emerging graphene-based technologies and biomedical applications.

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“…[16][17][18] As a relatively new member of the nanocarbon materials family, graphene also exhibits possible applications in biomedical schemes, such as drug delivery and regenerative medicine. 19,20 There are already many reports that discuss the properties and biomedical applications of carbon nanotubes, graphene and even amorphous carbon nanoparticles. [21][22][23][24] In this review, we focus on the therapeutic applications (nanomedicine and drug delivery) of spherical nanocarbon materials, mainly fullerene nanoparticles, carbon nanohorn aggregates, nanodiamonds and porous carbon nanospheres (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic applications of low-toxicity spherical nanocarbon materials

Wang

et al. 2014

NPG Asia Mater

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Nanocarbon materials have received considerable attention due to their unique structure and properties, which make them promising candidate materials for use in biomedical applications. In this review, we discuss the therapeutic applications of spherical nanocarbon materials, including fullerene nanoparticles, carbon nanohorn aggregates, nanodiamonds and porous carbon nanospheres, and their toxicology in biological systems. We put special emphasis on the antitumor effects of these multifunctional nanoparticles, which operate via novel mechanisms in a highly efficient manner. The low toxicities of these spherical nanocarbon materials as well as the possible effects of shape on toxicity are discussed.

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Highly Wrinkled Cross‐Linked Graphene Oxide Membranes for Biological and Charge‐Storage Applications

Cited by 112 publications

References 43 publications

Evaporation induced wrinkling of graphene oxide at the nanoparticle interface

Evaporation induced wrinkling of graphene oxide at the nanoparticle interface

Reduction of graphene oxide by resveratrol: a novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule

Therapeutic applications of low-toxicity spherical nanocarbon materials

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