Highly Water‐Dispersible Biocompatible Magnetite Particles with Low Cytotoxicity Stabilized by Citrate Groups

Abstract

Uniform magnetite particles stabilized by citrate groups were successfully synthesized by a modified high‐temperature solvothermal reaction. Cell imaging reveals that the water‐dispersible particles can readily penetrate into cells without destroying them, indicating an excellent biocompatibility. A high enrichment capacity of the magnetite particles for separation of trace peptides is observed.

Solvothermal synthesis of magnetic spinel ferrites

“…[6869707172737475] However, the water dispersal of SFNs that synthesized by these methods was weak, which leads to the limitation of their biomedical applications. [33] In 2005, Deng et al . [31] reported the chemical synthesis of single-crystalline magnetic microspheres including magnetite via SFM.…”

Synthesis of Iron Oxide Nanoclusters with Enhanced Magnetization and Their Applications in Pulsed Magneto-Motive Ultrasound Imaging

“…[21][22][23][24] Unlike organic solution synthesis, NPs synthesized in water do not need a phase-transfer process for enhanced water-dispersibility and can be directly modi¯ed with biomolecules. [25][26][27][28][29][30] NPs can be assembled into clusters through various noncovalent interactions including hydrogen bonding, 21,31 van der Waals (VDW) forces, 21,32 and electrostatic forces. 22,24 For superparamagnetic IO NPs under external¯eld, there are also magnetic dipole interactions between particles.…”

Adsorption of Cu2+ on Epichlorohydrin-Modified Magnetic Fe3O4 Microspheres Prepared by One-Step Solvothermal Synthesis

“…These microspheres have great potential as magnetic adsorbents or magnetic carriers due to their magnetic property, chemical stability and biocompatibility (Gawande et al 2013;Giakisikli and Anthemidis 2013;Ma et al 2014;Tang and Lo 2013;Teixeira et al 2012;Xu et al 2013;Yang et al 2011). They have been applied in various applications in the fields of magnetic separation, biotechnology, environmental remediation and catalysis; for example, ethylenediaminetetraacetic acid-modified Fe 3 O 4 microspheres were used as a magnetic adsorbent for the removal of heavymetal ions from wastewater (Chen et al 2014b;Liu et al 2013); Fe 3 O 4 @nSiO 2 @mSiO 2 microspheres were used as a reusable absorbent for fast, convenient and high-efficient removal of microcystins (Deng et al 2007); citrate-stabilized Fe 3 O 4 microspheres were used for efficient and convenient enrichment of trace peptides (Liu et al 2009); poly(methyl methacrylate)-modified Fe 3 O 4 microspheres were used as an effective drug-delivery carrier for the anticancer drug doxorubicin ); Fe 3 O 4 @polyaniline@Au microspheres were used as a magnetically recoverable reduction catalyst (Xuan et al 2009) and chitosan-modified Fe 3 O 4 microspheres were used as a replacement for enzymes in immunosorbent assay (Gao et al 2008).…”

“…silica and carbon; Deng et al 2007Deng et al , 2010Kong et al 2010;Ou et al 2012;Shao et al 2011;Tristão et al 2011;Xuan et al 2007;Yao et al 2012;Zhu and Diao 2011) or by organic groups (e.g. carboxylic or amine groups; Gao et al 2008;Gupta et al 2014;Liu et al 2009;Wang et al 2006;Xin et al 2012;Xuan et al 2009 Xia et al 2014). Third, the adsorbed Cu 2+ on ECH-modified Fe 3 O 4 microspheres are precursors to prepare Cu nanocatalysts for the synthesis of useful organic compounds (e.g.…”