Highly-trained dogs’ olfactory system for detecting biochemical recurrence following radical prostatectomy

Taverna, Gianluigi; Tidu, Lorenzo; Grizzi, Fabio; Stork, Brian; Mandressi, A.; Seveso, M.; Bozzini, Giorgio; Sardella, Paolo; Latorre, Giuseppe; Lughezzani, Giovanni; Buffi, Nicolò Maria; Casale, Paolo; Fiorini, Girolamo; Lazzeri, Massimo; Guazzoni, Giorgio

doi:10.1515/cclm-2015-0717

Cited by 6 publications

(11 citation statements)

References 18 publications

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“…Based on these observations, some researchers started to analyse PC-specific VOCs for tumour diagnosis [34,35]. …”

Section: Electronic Noses For Urine Sample Analysismentioning

confidence: 99%

“…Recently, Taverna et al [34] reported the capability of two highly trained dogs to discriminate urine samples of patients having prostate cancer from healthy ones, achieving a diagnostic accuracy in terms of both sensitivity and specificity of over 97%, and subsequently for detecting biochemical recurrence following radical prostatectomy [35]. …”

Section: Introductionmentioning

confidence: 99%

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Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Capelli

Taverna

Bellini

et al. 2016

Sensors

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The electronic nose is able to provide useful information through the analysis of the volatile organic compounds in body fluids, such as exhaled breath, urine and blood. This paper focuses on the review of electronic nose studies and applications in the specific field of medical diagnostics based on the analysis of the gaseous headspace of human urine, in order to provide a broad overview of the state of the art and thus enhance future developments in this field. The research in this field is rather recent and still in progress, and there are several aspects that need to be investigated more into depth, not only to develop and improve specific electronic noses for different diseases, but also with the aim to discover and analyse the connections between specific diseases and the body fluids odour. Further research is needed to improve the results obtained up to now; the development of new sensors and data processing methods should lead to greater diagnostic accuracy thus making the electronic nose an effective tool for early detection of different kinds of diseases, ranging from infections to tumours or exposure to toxic agents.

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“…Based on these observations, some researchers started to analyse PC-specific VOCs for tumour diagnosis [34,35]. …”

Section: Electronic Noses For Urine Sample Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Capelli

Taverna

Bellini

et al. 2016

Sensors

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“…The study also suggested the release of significant amount of VOCs in urine of patient. Recent study showed that highly trained dogs can discriminate urine samples of patients having prostate cancer from healthy ones, achieving a diagnostic accuracy in terms of both sensitivity and specificity of over 97 percent, which can subsequently detect the biochemical recurrence following radical prostatectomy [26][27].…”

Section: Prostate Cancermentioning

confidence: 99%

Dog Nose to E-Nose in Disease Diagnosis

Ranjan¹,

Singh²

2018

JAB

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Dog has natural gift of better smelling power which can be exploited for several purposes and disease diagnosis is one amongst them. The work on the use of dog nose in disease diagnosis is in preliminary stage. The electronic noses/e-noses are sensor based physical devices which are used to detect and analyse the various volatile organic compounds (VOCs) specific for health disorders including cancer to metabolic and infectious diseases. The sensor based disease diagnosis is also in preliminary stage. The data generated through studies conducted on disease diagnosis using one of the best noses of the universe may improve the sensitivity and specificity of existing e-noses to add par and this refined artificial intelligence, web data bases and sophisticated hardware and software may play in future a major role in field of diagnosis, monitoring and surveillance of human and animal diseases.

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“…Some studies have reported thresholds ranging from parts-per-million to part-for-trillion (Leitch et al, 2013). It has also been reported that highly trained dogs can accurately detect distinctive odors, also named volatile organic compounds (VOCs) that are present in urine of men with prostate cancer as products of cell metabolism (Willis et al, 2004;Gordon et al, 2008;Cornu et al, 2011;Jobu et al, 2012;Leitch et al, 2013;Taverna et al, 2015;Taverna et al, 2016;Guest et al, 2021). As dogs can reliably detect these compounds, it follows that they could also be used to test scent control products, such as a fabric stoma pouch cover.…”

Section: Introductionmentioning

confidence: 99%

“…As dogs can reliably detect these compounds, it follows that they could also be used to test scent control products, such as a fabric stoma pouch cover. The literature also reports the reliability of dogs to detect distinctive VOC urine odors (Taverna et al, 2015;Taverna et al, 2016;Guest et al, 2021). In this study, we aimed to evaluate the efficacy of a fabric to reduce or inhibit urine odor.…”

Section: Introductionmentioning

confidence: 99%

Hope for Ostomates: A Carbon and Zeolite Impregnated Polyester Fabric Inhibits Urine Odor in Cancer Patients: A Randomized Experimental Study

Taverna

Thiel

Miller

et al. 2021

Asian Pac J Cancer Prev

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Objective: Many individuals with bladder cancer have undergone a surgical urostomy and often complain of being self-conscious of the unpleasant smell of their own urine. The focus of this study was to test the efficacy of a pouch cover made of a carbon and zeolite containing polyester material to inhibit the smell of urine by comparing two trained dogs' response time in detecting volatile organic compounds (VOCs) in urine, with and without the fabric covering the samples. Methods: This study used a randomized, blinded experimental design to evaluate the efficacy of a fabric to interfere with two highly trained dogs' ability to detect specific VOCs present in the urine of prostate cancer patient. Ninety urine samples were analyzed in this study. Results: Prior to the experiment, both dogs accurately detected VOCs in the uncovered test urine samples of men with prostate cancer with a sensitivity and specificity of nearly 100%. Both dogs recognized the "uncovered" urine samples of men with prostate cancer within two seconds. When the test sample was covered with the study fabric, the test urine samples were detected within 30-40 seconds and in some instances the dogs were not able to identify the covered samples, whatsoever. Conclusion: The findings of this study demonstrate that the carbon and zeolite containing polyester fabric did significantly interfere with the ability of the dogs to detect VOCs in urine of men with prostate cancer. The fabric may show promise as a pouch cover in controlling offensive urine odor which many ostomates experience.

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Highly-trained dogs’ olfactory system for detecting biochemical recurrence following radical prostatectomy

Cited by 6 publications

References 18 publications

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Dog Nose to E-Nose in Disease Diagnosis

Hope for Ostomates: A Carbon and Zeolite Impregnated Polyester Fabric Inhibits Urine Odor in Cancer Patients: A Randomized Experimental Study

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