Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

Sun, Jishuai; Sun, Mingyang; Zang, Jiachen; Zhang, Tuo; Lv, Chenyan; Zhao, Guanghua

doi:10.1021/acsami.3c09615

Cited by 9 publications

(2 citation statements)

References 50 publications

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“…Previous studies have already demonstrated that OHy cross-linked porcine gelatin hydrogel exhibits excellent biodegradability and biocompatibility, but fish gelatin and OHy cross-linked hydrogel have not been reported. 30 Recently, 65 it has been reported that fish gelatin, without other drugs or growth factors, can promote cell proliferation and migration in vitro and positively affect wound healing. Furthermore, the angiogenesis and ECM regeneration efficacy of hyaluronate and its derivatives have been proven to be sufficient for application in wound dressing research.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Park,

Kim,

Jang

et al. 2024

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Park,

Kim,

Jang

et al. 2024

J. Mater. Chem. B

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“…Among the 18 amino acids that make up gelatin protein, 7 are necessary for the human body, and it does not contain cholesterol, which is an ideal protein source. Fish gelatin (FG) dressing is a type of biological dressing that has the advantages of low antigenicity, high biodegradability, and no cytotoxicity, which enhances wound healing [5][6][7]. Fish gelatin is widely used in wound [8,9] and hemostatic dressings [10].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Evaluation of Enzyme Co-Modified Fish Gelatin-Based Antibacterial Derivatives

Zhu,

Xiao,

et al. 2024

Polymers

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Fish gelatin (FG)-based wound dressings exhibit superior water absorption capacity, thermal stability, and gelation properties, which enhance the performance of these dressings. In this study, our objective was to investigate the conditions underlying the enzymatic hydrolysis of FG and subsequent cross-linking to prepare high-performance gels. A two-step enzymatic method of protease-catalyzed hydrolysis followed by glutamine transglutaminase (TGase)-catalyzed cross-linking was used to prepare novel high-performance fish gelatin derivatives with more stable dispersion characteristics than those of natural gelatin derivatives. Compared with conventional TGase cross-linked derivatives, the novel derivatives were characterized by an average pore size of 150 μm and increased water solubility (423.06% to 915.55%), water retention (by 3.6-fold to 43.89%), thermal stability (from 313 °C to 323 °C), and water vapor transmission rate, which reached 486.72 g·m−2·24 h−1. In addition, loading glucose oxidase onto the fish gelatin derivatives increased their antibacterial efficacy to >99% against Escherichia coli and Staphylococcus aureus.

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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Guo,

Luo,

et al. 2024

Advanced Science

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Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties in preparation, side effects, and clinical translation. Recently, significant progress has been achieved in terms of direct self‐assembly of natural products from herbal medicine (NPHM), an important source for novel medications, resulting in a wide range of bioactive supramolecular materials including gels, and nanoparticles. The NPHM‐based supramolecular bioactive materials are produced from renewable resources, are simple to prepare, and have demonstrated multi‐functionality including slow‐release, smart‐responsive release, and especially possess powerful biological effects to treat various diseases. In this review, NPHM‐based supramolecular bioactive materials have been revealed as an emerging, revolutionary, and promising strategy. The development, advantages, and limitations of NPHM, as well as the advantageous position of NPHM‐based materials, are first reviewed. Subsequently, a systematic and comprehensive analysis of the self‐assembly strategies specific to seven major classes of NPHM is highlighted. Insights into the influence of NPHM structural features on the formation of supramolecular materials are also provided. Finally, the drivers and preparations are summarized, emphasizing the biomedical applications, future scientific challenges, and opportunities, with the hope of igniting inspiration for future research and applications.

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Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

Cited by 9 publications

References 50 publications

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Preparation, Characterization, and Evaluation of Enzyme Co-Modified Fish Gelatin-Based Antibacterial Derivatives

Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

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