Highly Stable and Fine-Textured Hybrid Microspheres for Entrapment of Cosmetic Active Ingredients

Abstract

This study details the preparation and application of supramolecular host−guest inclusion complexes entrapping biomineralized microspheres for long-term storage and their pHresponsive behavior. The microspheres were assembled using a CaCO 3 synthesis process coupled with cyclodextrin−tetrahydrocurcumin (CD−THC) inclusion complexes, forming fine-textured and mechanically stable hybrid materials. The products were successfully characterized using field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and particle size analysis (PSA). Various parameters such as the Brunauer−Emmett−Teller (BET) surface area, single point total pore volume, and pore size via adsorption/desorption analysis were also determined. The obtained THC-entrapped hybrid microspheres contained as high as 20 wt % THC loading and were very stable, preserving 90% of the initial concentration over four weeks of storage at different temperatures, largely limiting THC leaching and indicating high stability in a physiological environment. In addition, the pHresponsive release of THC from the hybrid microspheres was observed, showing potential use for application to weakly acidic skin surfaces. To our knowledge, this is the first demonstration of antiaging cosmetic formulation technology using biomineralization based on the co-synthesis of CaCO 3 and CD−THC complexes.

Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis

“…[24][25][26] The preferred properties derived from biodegradability, such as degrading into non-toxic products and having pH-sensitive solubility in acidic environments, are also inspired by the application of diverse additives to simultaneously control crystal nucleation and growth during crystallization. 27,28 In addition to these properties, such as simple synthesis, low cost, safety, and pH-responsive properties, advantages such as a high immobilization surface area and high porosity have shown great potential in the past decade in carrier systems, particularly protein encapsulation, with increasing popularity. [29][30][31] In addition, the pores of calcium carbonate can be controlled, allowing for a more selective loading of molecules and making it a suitable material that serves as a carrier for therapeutic enzymes.…”

A Metronidazole-Modeled Central Composite Design Strategy for Plantago ovata Seed Mucilage-Supported Floating Microspheres for Helicobacter pylori Eradication

“…The mixture was filtered and the filtrate was analyzed at 278 nm spectrophotometrically (Elico Spectrophotometer, SL-174). EE was calculated based on the ratio of the actual amount of MNZ in the formulation to the amount initially added [16].…”

Single Infrared Spectrum Enables Simultaneous Identification of (Bio)Chemical Nature and Particle Size of Microorganisms and Synthetic Microplastic Beads

“…Dielectric synthetic microparticles are used in many applications such as drug delivery, 1−3 medical applications, 4 cosmetics, 5,6 and many industrial applications. 7,8 Another class of dielectric microparticles includes all living microorganisms, which include pollen grains 9 and yeast, 10 in addition to a wide variety of biological cells.…”

“…Dielectric synthetic microparticles are used in many applications such as drug delivery, − medical applications, cosmetics, , and many industrial applications. , Another class of dielectric microparticles includes all living microorganisms, which include pollen grains and yeast, in addition to a wide variety of biological cells. All those particles are more often than not made of large populations, and another important specificity is that they have nearly the same shape and the same chemical nature within a given population.…”