Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development

Szente, Lajos; Szejtli, J.

doi:10.1016/s0169-409x(98)00092-1

Cited by 485 publications

(256 citation statements)

References 31 publications

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“…saccharides, cyclodextrins, makes them ideal for their use in delivery systems [1]. Metal, carbon and ceramic nanotubes also may be used as carrier materials.…”

mentioning

confidence: 99%

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Hári

Gyürki

Sárközi

et al. 2016

Journal of Colloid and Interface Science

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Halloysite nanotubes used as potential carrier material for a controlled release stabilizer in polyethylene were thoroughly characterized with several techniques including the measurement of specific surface area, pore volume and surface energy. The high surface energy of the halloysite results in the strong bonding of the additive to the surface.Dissolution experiments carried out with eight different solvents for the determination of the effect of solvent characteristics on the amount of irreversibly bonded quercetin proved that adsorption and dissolution depend on competitive interactions prevailing in the system. Solvents with low polarity dissolve only surplus quercetin adsorbed in multilayers.Polyethylene is a very apolar polymer forming weak interactions with every substance; quercetin dissolves into it only above a critical concentration. Stabilization experiments confirmed that strong adhesion prevents dissolution and results in limited stabilization efficiency. At larger adsorbed amounts better stability and extended effect were measured indicating dissolution and controlled release.

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“…saccharides, cyclodextrins, makes them ideal for their use in delivery systems [1]. Metal, carbon and ceramic nanotubes also may be used as carrier materials.…”

mentioning

confidence: 99%

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Hári

Gyürki

Sárközi

et al. 2016

Journal of Colloid and Interface Science

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“…The variation in the shape, shift, and intensity of the FT-IR absorption peaks for the guest or host can provide enough evidence for inclusion [15]. The FT-IR spectra of the inclusion complex MBC·CDM-AM and the inclusion complex NM·CDM-AM were presented in Figure3e.…”

Section: Resultsmentioning

confidence: 99%

The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs

Tang²,

Zhou

2018

Designed Monomers and Polymers

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The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.

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“…A wide variety of nanomaterials are used to achieve the controlled release function. Cyclodextrin, a cyclic oligosaccharide containing a number of hydrogen donor and acceptor groups and an internal lipophobic surface, can host various molecules in its cavity and is frequently used in delivery systems [1]. Various natural and synthetic polymers like liposomes, polymer micelles, nanoparticles and nanogels are available as controlled release carriers, but porous nanoparticles and various nanofillers with tubular structure are also often used as supports in such applications.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of an active molecule on the surface of halloysite for controlled release application: Interaction, orientation, consequences

Hári

Polyák

Mester

et al. 2016

Applied Clay Science

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The goal of the study was to check the possible use of halloysite nanotubes as a controlled release natural antioxidant device with quercetin as the active component. The mineral was thoroughly characterized by various techniques including the determination of particle and tube morphology, specific surface area, pore size and volume, as well as surface energy. The high surface energy of halloysite predicted strong adsorption of active molecules on its surface and consequently difficult release. FTIR spectroscopy confirmed the existence of strong interactions, energetically heterogeneous halloysite surface and multilayer coverage at large loadings. FTIR and XRD experiments proved the complete lack of intercalation and showed that below 3.5 wt% quercetin loading, most of the molecules are located within the halloysite tubes. Molecular modelling indicated the parallel orientation of quercetin molecules with the surface. Critical concentrations derived from various measurements agreed well with each other further confirming that up to about 4.0 wt% loading, quercetin is bonded very strongly to the halloysite surface. As a consequence, the dissolution of active molecules is very difficult or impossible, especially into apolar media, thus neither stabilization nor controlled release effect can be expected below that concentration.

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Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development

Cited by 485 publications

References 31 publications

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs

Adsorption of an active molecule on the surface of halloysite for controlled release application: Interaction, orientation, consequences

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