Highly sensitive visual detection of copper (II) using water-soluble azide-functionalized gold nanoparticles and silver enhancement

Zhang, Zhen; Li, Wenqing; Zhao, Qiuling; Cheng, Ming; Xu, Li; Fang, Xiaohong

doi:10.1016/j.bios.2014.03.003

Cited by 38 publications

(12 citation statements)

References 56 publications

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“…High molecular weight PEG-stabilized nanoparticles were reported to be the less toxic, 134 and bifunctional PEG derivatives were also reported to be mostly employed for the PEGylation of nanoparticles. 135,136 In a study by Sosibo et al, 132 The PEG-OH was used because of its versatility with regard to solubility and biological compatibility, while the PEG-biotin allowed the immobilization of streptavidin-a linker between PEGylated biotin on the surface of AuNPs and biotinylated trans-activator of the transcription peptide. This approach reduced the risk of introducing toxic reagents during the coupling reaction and provides a suitable design of multilayered nanoconjugates for various applications in nanomedicine.…”

Section: Surface Chemistrymentioning

confidence: 99%

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Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

et al. 2019

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Potential applications of gold nanoparticles in biomedicine have increasingly been reported on account of the ease of synthesis, bioinert characteristics, optical properties, chemical stability, high biocompatibility, and specificity. The safety of these particles remains a great concern, as there are differences among toxicity study protocols used. This article focuses on integrating results of research on the toxicological behavior of gold nanoparticles. This can be influenced by the physicochemical properties, including size, shape, surface charge, and other factors, such as methods used in the synthesis of gold nanoparticles, models used, dose, in vivo route of administration, and interference of gold nanoparticles with in vitro toxicity assay systems. Several researchers have reported toxicological studies with regard to gold nanoparticles, using various in vitro, in vivo, and in ovo models. The conflicting results concerning the toxicity of gold nanoparticles should thus be addressed to justify the safe use of gold nanoparticles in biomedicine.

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Section: Surface Chemistrymentioning

confidence: 99%

Section: Factors Influencing the Toxicity Of Aunpsmentioning

confidence: 99%

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

et al. 2019

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“…Following these reports, several groups have used the CuAAC reaction of AuNPs as a means for the detection of copper(II) salts [ 65 – 67 ] and ascorbic acid [ 68 ], and also for protein quantification (i.e., for proteins capable of reducing Cu(II) to Cu(I)) [ 69 ]. The basis of these detection systems was that two sets of AuNPs were synthesized, one of which was functionalized with azide-containing ligands and the other with alkyne-containing ligands.…”

Section: Reviewmentioning

confidence: 99%

Recent applications of click chemistry for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles

Poonthiyil¹,

Lindhorst²,

Golovko³

et al. 2018

Beilstein J. Org. Chem.

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Glycoscience, despite its myriad of challenges, promises to unravel the causes of, potential new detection methods for, and novel therapeutic strategies against, many disease states. In the last two decades, glyco-gold nanoparticles have emerged as one of several potential new tools for glycoscientists. Glyco-gold nanoparticles consist of the unique structural combination of a gold nanoparticle core and an outer-shell comprising multivalent presentation of carbohydrates. The combination of the distinctive physicochemical properties of the gold core and the biological function/activity of the carbohydrates makes glyco-gold nanoparticles a valuable tool in glycoscience. In this review we present recent advances made in the use of one type of click chemistry, namely the azide–alkyne Huisgen cycloaddition, for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles.

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“…Compared with conventional methods, this biosensor is simpler to operate and more cost-effective to use, thus has great potential in point-of-care diagnosis and environmental monitoring. To achieve a high sensitivity for detection of Cu (II), a silver enhancement signal amplification strategy is employed to achieve highly sensitive detection of copper ions in aqueous solution 88 (Figure 2 B) . Based on Cu(I)-catalyzed 'click' reaction between azide-functionalized Au NPs and alkyne-modified glass slide, this method enables Cu(II) detection down to 62 pM by the commonly used flatbed scanner, which is 2-3 orders of magnitude lower than those in previous reports.…”

Section: Biochemical Assays Via Detection Of the Components Of Cuamentioning

confidence: 99%

Click Chemistry-Mediated Nanosensors for Biochemical Assays

Chen

Xianyu

et al. 2016

Theranostics

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Click chemistry combined with functional nanoparticles have drawn increasing attention in biochemical assays because they are promising in developing biosensors with effective signal transformation/amplification and straightforward signal readout for clinical diagnostic assays. In this review, we focus on the latest advances of biochemical assays based on Cu (I)-catalyzed 1, 3-dipolar cycloaddition of azides and alkynes (CuAAC)-mediated nanosensors, as well as the functionalization of nanoprobes based on click chemistry. Nanoprobes including gold nanoparticles, quantum dots, magnetic nanoparticles and carbon nanomaterials are covered. We discuss the advantages of click chemistry-mediated nanosensors for biochemical assays, and give perspectives on the development of click chemistry-mediated approaches for clinical diagnosis and other biomedical applications.

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Highly sensitive visual detection of copper (II) using water-soluble azide-functionalized gold nanoparticles and silver enhancement

Cited by 38 publications

References 56 publications

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

Recent applications of click chemistry for the functionalization of gold nanoparticles and their conversion to glyco-gold nanoparticles

Click Chemistry-Mediated Nanosensors for Biochemical Assays

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