Highly sensitive surface-enhanced Raman scattering detection of adenosine triphosphate based on core–satellite assemblies

Tian, Ya-Fei; Zhou, Wen; Yin, Bin‐Cheng; Ye, Bang‐Ce

doi:10.1039/c7ay02096a

Cited by 18 publications

(3 citation statements)

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“…Due to the importance of this bioanalyte, many studies have been reported using different approaches to its investigation [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. The most commonly employed method used to characterize the physiologically relevant forms of adenosine is based on electrochemical detection [ 13 , 22 , 23 , 24 , 25 ], which was initiated by Dryhurst [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…As alternatives, recent research has also considered optical approaches for accurate and sensitive adenosine detection, such as those employing UV-VIS absorption or those centered on surface-enhanced Raman spectroscopy (SERS) [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Unfortunately, the accuracy of tracking adenosine with UV-VIS absorption, which has a signature at 260 nm, was reported to be quite low due to interference of other bioanalytes in the same optical window [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the accuracy of tracking adenosine with UV-VIS absorption, which has a signature at 260 nm, was reported to be quite low due to interference of other bioanalytes in the same optical window [ 28 ]. However, in view of the importance of this purine nucleoside in human physiology, the literature in SERS investigations of adenosine is surprisingly limited [ 29 , 30 , 31 , 32 , 33 , 34 ]. The literature employing comparison of SERS experimental vibrational spectra of adenosine with quantum chemical calculations is even scarcer [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Computational and Experimental Detection of Adenosine Using Ultrasensitive Surface-Enhanced Raman Spectroscopy

Sundin

Ciubuc

Bennet

et al. 2018

Sensors

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To better understand detection and monitoring of the important neurotransmitter adenosine at physiological levels, this study combines quantum chemical density functional modeling and ultrasensitive surface-enhanced Raman spectroscopic (SERS) measurements. Combined simulation results and experimental data for an analyte concentration of about 10−11 molar indicate the presence of all known molecular forms resulting from adenosine’s complex redox-reaction. Detailed analysis presented here, besides assessing potential Raman signatures of these adenosinic forms, also sheds light on the analytic redox process and voltammetric detection. Examples of adenosine Raman fingerprints for different molecular orientations with respect to the SERS substrate are the vibrational line around 920 ± 10 cm−1 for analyte physisorption through the carbinol moiety and around 1600 ± 20 cm−1 for its fully oxidized form. However, both hydroxyl/oxygen sites and NH2/nitrogen sites contribute to molecule’s interaction with the SERS environment. Our results also reveal that contributions of partially oxidized adenosine forms and of the standard form are more likely to be detected with the first recorded voltammetric oxidation peak. The fully oxidized adenosine form contributes mostly to the second peak. Thus, this comparative theoretical–experimental investigation of adenosine’s vibrational signatures provides significant insights for advancing its detection, and for future development of opto-voltammetric biosensors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Computational and Experimental Detection of Adenosine Using Ultrasensitive Surface-Enhanced Raman Spectroscopy

Sundin

Ciubuc

Bennet

et al. 2018

Sensors

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Metal Nanoparticles‐Enhanced Biosensors: Synthesis, Design and Applications in Fluorescence Enhancement and Surface‐enhanced Raman Scattering

Yaraki

Tan

2020

Chemistry An Asian Journal

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Metal nanoparticles (NP) that exhibit localized surface plasmon resonance play an important role in metalenhanced fluorescence (MEF) and surface-enhanced Raman scattering (SERS). Among the optical biosensors, MEF and SERS stand out to be the most sensitive techniques to detect a wide range of analytes from ions, biomolecules to macromolecules and microorganisms. Particularly, anisotropic metal NPs with strongly enhanced electric field at their sharp corners/edges under a wide range of excitation wavelengths are highly suitable for developing the ultrasensitive plasmonenhanced biosensors. In this review, we first highlight the reliable methods for the synthesis of anisotropic gold NPs and silver NPs in high yield, as well as their alloys and composites with good control of size and shape. It is followed by the discussion of different sensing mechanisms and recent advances in the MEF and SERS biosensor designs. This includes the review of surface functionalization, bioconjugation and (directed/self) assembly methods as well as the selection/screening of specific biorecognition elements such as aptamers or antibodies for the highly selective biodetection. The right combinations of metal nanoparticles, biorecognition element and assay design will lead to the successful development of MEF and SERS biosensors targeting different analytes both in-vitro and in-vivo. Finally, the prospects and challenges of metal-enhanced biosensors for future nanomedicine in achieving ultrasensitive and fast medical diagnostics, high-throughput drug discovery as well as effective and reliable theranostic treatment are discussed.

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SERS spectroscopy using Au-Ag nanoshuttles and hydrophobic paper-based Au nanoflower substrate for simultaneous detection of dual cervical cancer–associated serum biomarkers

et al. 2020

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Highly sensitive surface-enhanced Raman scattering detection of adenosine triphosphate based on core–satellite assemblies

Abstract: As an important small molecule, adenosine triphosphate (ATP) plays an important role in the regulation of cell metabolism and supplies energy for various biochemical reactions in organisms.

Cited by 18 publications

References 48 publications

Comparative Computational and Experimental Detection of Adenosine Using Ultrasensitive Surface-Enhanced Raman Spectroscopy

Comparative Computational and Experimental Detection of Adenosine Using Ultrasensitive Surface-Enhanced Raman Spectroscopy

Metal Nanoparticles‐Enhanced Biosensors: Synthesis, Design and Applications in Fluorescence Enhancement and Surface‐enhanced Raman Scattering

SERS spectroscopy using Au-Ag nanoshuttles and hydrophobic paper-based Au nanoflower substrate for simultaneous detection of dual cervical cancer–associated serum biomarkers

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