Highly sensitive sensing of food additives based on fluorescent carbon quantum dots

Carneiro, Samuel Veloso; Holanda, M.H.B.; Cunha, H.O.; Oliveira, José Alberto Alves; Pontes, Sheyliane Maria Adriano; Cruz, A.A.C.; Fechine, Lillian Maria Uchôa Dutra; Moura, Thiago Alves de; Paschoal, Alexandre Rocha; Zambelli, Rafael Audino; Freire, Rafael M.; Fechine, Pierre Basílio Almeida

doi:10.1016/j.jphotochem.2021.113198

Cited by 23 publications

(12 citation statements)

References 45 publications

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“…The synthetic methods such as microwave pyrolysis or hydrothermal methods are highly appreciated to formulate size-controlled CQDs and avoid carbonaceous aggregation. Unique properties of CQDs obtained from food wastes are responsible for their usage in food analysis as well as in the detection of heavy metals, food chemicals, pathogens in food, and food additives (Fan et al, 2020;Carneiro et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…CQDs were synthesized from a leguminous plant known as flamboyant mirim (FM) as this is a cost-effective and environmentally friendly sensing technique. After their spectroscopy evaluation, PL response of CQDs was checked by LDA in the presence of citric acid, lactic acid, ascorbic acid, potassium sorbate, and sodium benzoate; these substances are used in the formulation of food products, and then FM-CQDs are used as imaging probes in the detection of additives in pickled olives (Carneiro et al, 2021). So, it can be concluded that CQDs synthesized from natural sources have potential to be used in the detection of food toxins including food pathogens, heavy metals, and toxic chemicals.…”

Section: Food Toxin Detectionmentioning

confidence: 99%

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Carbon Quantum Dots for Biomedical Applications: Review and Analysis

2021

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Carbon quantum dots (CQDs) are a new type of nano-carbons that are currently favored over semiconductor quantum dots (QDs) because of their solubility, low toxicity, eco-friendliness, and cheap and facile synthesis giving desired optical characteristics. Moreover, their physiochemical properties can be controlled by their synthetic route. CQDs can emit fluorescence in the range from the UV to the near-infrared (NIR) region, making them suitable for biomedical applications. Fluorescence in these nano-carbon atoms can be tuned by varying the excitation wavelength. As of now, CQDs have been used in various applications such as in bioimaging, biosensing, electrochemical biosensing, drug delivery, gene delivery, photodynamic therapy in the treatment of cancers, pharmaceutical formulations, and treating inflammation. This article highlights the current progress and advancement of CQDs with focus on their synthetic routes, chemical and optical properties, and biomedical applications along with new perceptions in this interesting and promising field.

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Section: Discussionmentioning

confidence: 99%

Section: Food Toxin Detectionmentioning

confidence: 99%

Carbon Quantum Dots for Biomedical Applications: Review and Analysis

2021

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“…The B,N-Cdot Raman spectrum provides information regarding crystallinity of the nanoparticles. Figure b illustrates the two peaks with the highest intensity, obtained from the spectrum deconvolution at 1385 and 1510 cm –1 , assigned to the D and G bands, respectively . The intensity ratio I D / I G of the Raman D (disorder) and G (crystalline) carbon bands are often used to determine graphene sheet or carbon nanotube quality .…”

Section: Resultsmentioning

confidence: 99%

“…Figure 2b illustrates the two peaks with the highest intensity, obtained from the spectrum deconvolution at 1385 and 1510 cm −1 , assigned to the D and G bands, respectively. 59 The intensity ratio I D /I G of the Raman D (disorder) and G (crystalline) carbon bands are often used to determine graphene sheet or carbon nanotube quality. 60 Herein, the I D /I G ratio was 0.80, indicating the presence of few defects in the carbon core of the synthesized B,N-Cdots.…”

Section: Characterization Of Bn-cdotmentioning

confidence: 99%

Doped Carbon Quantum Dots/PVA Nanocomposite as a Platform to Sense Nitrite Ions in Meat

Carneiro

Oliveira

Rodrigues

et al. 2022

ACS Appl. Mater. Interfaces

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A sensor device based on doped-carbon quantum dots is proposed herein for detection of nitrite in meat products by fluorescence quenching. For the sensing platform, carbon quantum dots doped with boron and functionalized with nitrogen (B,N-Cdot) were synthesized with an excellent 44.3% quantum yield via a one-step hydrothermal route using citric acid, boric acid, and branched polyethylenimine as carbon, boron, and nitrogen sources, respectively. After investigation of their chemical structure and fluorescent properties, the B,N-Cdot at aqueous suspensions showed high selectivity for NO2 – in a linear range from 20 to 50 mmol L–1 under optimum conditions at pH 7.4 and a 340 nm excitation. Furthermore, the prepared B,N-Cdots successfully detected NO2 – in a real meat sample with recovery of 91.4–104% within the analyzed range. In this manner, a B,N-Cdot/PVA nanocomposite film with blue emission under excitation at 360 nm was prepared, and a first assay detection of NO2 – in meat products was tested using a smartphone application. The potential application of the newly developed sensing device containing a highly fluorescent probe should aid in the development of a rapid and inexpensive strategy for NO2 – detection.

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“…LDA finds the linear combinations of the raw instrumental measurements that minimize the size of the cluster of replicates pertaining to each sample (intracluster distances) while maximizing the distances among clusters belonging to different analytes (intercluster distances), thus providing optimal separation among analyte clusters [29,30]. This method has been used for the discrimination of various analytes, including bacteria [31], proteins [32], wines [33], sugars [34,35], metal ions [36,37], food additives [38], and drugs [39].…”

Section: Antibiotics Discrimination At Ph 74mentioning

confidence: 99%

Beta-Lactam Antibiotic Discrimination Using a Macromolecular Sensor in Water at Neutral pH

Bonizzoni

2021

Sensors

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Penicillins and cephalosporins belong to the β-lactam antibiotic family, which accounts for more than half of the world market for antibiotics. Misuse of antibiotics harms human health and the environment. Here, we describe an easy, fast, and sensitive optical method for the sensing and discrimination of two penicillin and five cephalosporin antibiotics in buffered water at pH 7.4, using fifth-generation poly (amidoamine) (PAMAM) dendrimers and calcein, a commercially available macromolecular polyelectrolyte and a fluorescent dye, respectively. In aqueous solution at pH 7.4, the dendrimer and dye self-assemble to form a sensor that interacts with carboxylate-containing antibiotics through electrostatic interaction, monitored through changes in the dye’s spectroscopic properties. This response was captured through absorbance, fluorescence emission, and fluorescence anisotropy. The resulting data set was processed through linear discriminant analysis (LDA), a common pattern-base recognition method, for the differentiation of cephalosporins and penicillins. By pre-hydrolysis of the β-lactam rings under basic conditions, we were able to increase the charge density of the analytes, allowing us to discriminate the seven analytes at a concentration of 5 mM, with a limit of discrimination of 1 mM.

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Highly sensitive sensing of food additives based on fluorescent carbon quantum dots

Cited by 23 publications

References 45 publications

Carbon Quantum Dots for Biomedical Applications: Review and Analysis

Carbon Quantum Dots for Biomedical Applications: Review and Analysis

Doped Carbon Quantum Dots/PVA Nanocomposite as a Platform to Sense Nitrite Ions in Meat

Beta-Lactam Antibiotic Discrimination Using a Macromolecular Sensor in Water at Neutral pH

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