Highly Sensitive, Robust, and Recyclable TiO2/AgNP Substrate for SERS Detection

Lin, Hung‐Chun; Liu, Yung-Hsien; Chen, Kailin; Wang, Yu-Hsun; Sun, Yung-Shin; Hsu, Jin–Cherng

doi:10.3390/molecules27196755

Cited by 9 publications

(7 citation statements)

References 65 publications

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“…The uniformity and reproducibility of SERS substrates play significant roles in practical SERS applications [ 34 , 35 ]. For example, Figure 7 a,b show the SERS spectra of R6G (10 −6 M) at ten random points on CuO@Ag nanowires (30 s) and CuO@RF@Ag nanowires (0.45 mM), respectively.…”

Section: Resultsmentioning

confidence: 99%

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

Chang

et al. 2022

Molecules

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Vertical-aligned CuO nanowires have been directly fabricated on Cu foil through a facile thermal oxidation process by a hotplate at 550 °C for 6 h under ambient conditions. The intermediate layer of resorcinol–formaldehyde (RF) and silver (Ag) nanoparticles can be sequentially deposited on Cu nanowires to form CuO@RF@Ag core-shell nanowires by a two-step wet chemical approach. The appropriate resorcinol weight and silver nitrate concentration can be favorable to grow the CuO@RF@Ag nanowires with higher surface-enhanced Raman scattering (SERS) enhancement for detecting rhodamine 6G (R6G) molecules. Compared with CuO@Ag nanowires grown by ion sputtering, CuO@RF@Ag nanowires exhibited a higher SERS enhancement factor of 5.33 × 108 and a lower detection limit (10−12 M) for detecting R6G molecules. This result is ascribed to the CuO@RF@Ag nanowires with higher-density hot spots and surface-active sites for enhanced high SERS enhancement, good reproducibility, and uniformity. Furthermore, the CuO@RF@Ag nanowires can also reveal a high-sensitivity SERS-active substrate for detecting amoxicillin (10−10 M) and 5-fluorouracil (10−7 M). CuO@RF@Ag nanowires exhibit a simple fabrication process, high SERS sensitivity, high reproducibility, high uniformity, and low detection limit, which are helpful for the practical application of SERS in different fields.

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Section: Resultsmentioning

confidence: 99%

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

Chang

et al. 2022

Molecules

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“…On the other hand, a strong local field by LSPR sometimes causes several photochemical reactions, adhesion, or agglomeration of analyte molecules on metal nanoparticles during SERS measurement. , It is reported that the deposition of TiO 2 between the substrate and metal nanoparticles makes the SERS substrate recyclable. By ultraviolet light irradiation, TiO 2 induces photocatalytic degradation of analytes molecules. , This approach would be an effective approach to make this capillary tube tip recyclable. Our method would be a powerful tool, especially for environmentally hazardous substance detection, health care, or food analysis, where the sample volume and the concentration are extremely low.…”

Section: Discussionmentioning

confidence: 99%

“…By ultraviolet light irradiation, TiO 2 induces photocatalytic degradation of analytes molecules. 27,28 This approach would be an effective approach to make this capillary tube tip recyclable. Our method would be a powerful tool, especially for environmentally hazardous substance detection, health care, or food analysis, where the sample volume and the concentration are extremely low.…”

Section: ■ Conclusionmentioning

confidence: 99%

Capillary Tube Surface-Enhanced Raman Scattering Substrate and High-Sensitivity Molecule Detection

Minoshima

Shoji

2022

J. Phys. Chem. A

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Surface-enhanced Raman scattering (SERS) greatly improves molecule sensitivity compared with ordinary Raman spectroscopy. To excite and detect SERS efficiently, we fabricated glass-made microcapillary tubes decorated with silver nanoparticles inside them. The capillary tubes work as sample containers, where the required sample volume is in the order of a few nanoliters. The capillary tubes also play the role of optical waveguides. The tubes guide the excitation laser light through them so that the light illuminates whole silver nanoparticles inside the tubes at once. The tubes guide the SERS light to the tube end efficiently. The decoration of silver nanoparticles inside the tubes was performed by the silver mirror reaction. By making the tubes thinner and longer, highly sensitive SERS spectroscopy can be achieved. Our method would be a powerful tool for high-sensitivity molecule detection where the sample volume and concentration are extremely low.

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“…Although SERS promises impressive sensitivity and selectivity, it requires specialized and complex equipment. Nonetheless, it remains a widely popular technique for neurotransmitter detection [ 30 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ]. In recent works, research teams are exploring implantable SERS-based nanoprobes for direct neurotransmitter detection in the brain [ 69 , 102 , 103 , 104 , 105 ].…”

Section: In Vivo Neurotransmitter Sensing Techniquesmentioning

confidence: 99%

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance,

Gauvreau,

Boisselier

et al. 2024

Sensors

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Neurotransmitter analysis plays a pivotal role in diagnosing and managing neurodegenerative diseases, often characterized by disturbances in neurotransmitter systems. However, prevailing methods for quantifying neurotransmitters involve invasive procedures or require bulky imaging equipment, therefore restricting accessibility and posing potential risks to patients. The innovation of compact, in vivo instruments for neurotransmission analysis holds the potential to reshape disease management. This innovation can facilitate non-invasive and uninterrupted monitoring of neurotransmitter levels and their activity. Recent strides in microfabrication have led to the emergence of diminutive instruments that also find applicability in in vitro investigations. By harnessing the synergistic potential of microfluidics, micro-optics, and microelectronics, this nascent realm of research holds substantial promise. This review offers an overarching view of the current neurotransmitter sensing techniques, the advances towards in vitro microsensors tailored for monitoring neurotransmission, and the state-of-the-art fabrication techniques that can be used to fabricate those microsensors.

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Highly Sensitive, Robust, and Recyclable TiO2/AgNP Substrate for SERS Detection

Cited by 9 publications

References 65 publications

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application

Capillary Tube Surface-Enhanced Raman Scattering Substrate and High-Sensitivity Molecule Detection

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

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