2017
DOI: 10.2147/ijn.s145585
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Highly sensitive protein detection via covalently linked aptamer to MoS<sub>2</sub> and exonuclease-assisted amplification strategy

Abstract: Molybdenum disulfide (MoS 2 ) has shown highly attractive superiority as a platform for sensing. However, DNA physisorption on the surface of MoS 2 was susceptible to nonspecific probe displacement and false-positive signals. To solve these problems, we have developed a novel MoS 2 –aptamer nanosheet biosensor for detecting thrombin using a covalently linked aptamer to the MoS 2 nanosheet. Ten percent Tween 80 was used … Show more

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Cited by 24 publications
(4 citation statements)
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“…The high near infrared ray absorbance, extraordinary electrocatalytic activity, easy surface modification and low biological toxicity make MSNs one of the most promising graphene analogues with wide applications in various fields, especially in nanobiomedicine. 2 To date, MSNs have been developed for use as bio-imaging probes, 3 biosensors, [4][5][6] photothermal therapy agents, [7][8][9] drug carriers [10][11][12] and tissue engineering scaffolds, 13 among other uses. The possibility of using MSNs as immuneregulatory adjuvants to manipulate the immune responses is also a very fascinating and a meaningful research topic.…”
Section: Introductionmentioning
confidence: 99%
“…The high near infrared ray absorbance, extraordinary electrocatalytic activity, easy surface modification and low biological toxicity make MSNs one of the most promising graphene analogues with wide applications in various fields, especially in nanobiomedicine. 2 To date, MSNs have been developed for use as bio-imaging probes, 3 biosensors, [4][5][6] photothermal therapy agents, [7][8][9] drug carriers [10][11][12] and tissue engineering scaffolds, 13 among other uses. The possibility of using MSNs as immuneregulatory adjuvants to manipulate the immune responses is also a very fascinating and a meaningful research topic.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, exonuclease (Exo) catalyzed target circulation is also a common method of signal amplification [62]. Li et al, exploited a tactic for the aptamer-MoS 2 sensor based upon the strategy of fluorescence resonance energy transfer (FRET) to detect thrombin [63]. First, the double-stranded DNA (dsDNA) formed by TBA2 modified with carboxyfluorescein (FAM) and its complementary sequence modified with thiol group was immobilized on the Au nanoparticles (AuNPs) adsorbed on the surface of MoS 2 , and AuNPs@MoS 2 nanocomposites quenched the fluorescence of FAM.…”
Section: Fluorescent Sensorsmentioning
confidence: 99%
“…Schematic representation of fluorescent sensors for thrombin detection. (A) The thrombin detection sensor based on aptamer controlling FITC release from mesoporous silicon nanoparticles.Adapted with permission from Ref [63]…”
mentioning
confidence: 99%
“…They have been used in drug delivery, bioimaging, molecular sensing, gas and molecular separation, etc. [64][65][66][67]. Therefore, enzymes immobilized on MOFs have drawn increasing attention recently, and MOF materials such as zeolitic imidazolate framework-8 (ZIF-8), Tb-BDC, MIL-88, and HKUST-1 can maintain enzyme activity well [64,68]; for example, Candida antarctica lipase immobilized in B-IRMOFs has up to 1000-fold enhanced activity [69], and the activity of Cyt c embedded in ZIF-8 has been increased 10-fold [70].…”
Section: Metal-organic Frameworkmentioning
confidence: 99%