Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles

Marques, Leonel; Hernández, Francisco; James, Stephen W.; Morgan, Stephen P.; Clark, Matt; Tatam, Ralph P.; Korposh, Sergiy

doi:10.1016/j.bios.2015.08.046

Cited by 54 publications

(36 citation statements)

References 27 publications

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“…Finally, a series of other BREs, based on biointeractions such as enzymatic processes [58,59], biotin/streptavidin affinity [18,33,[60][61][62], virus-specific recognition (bacteriophage T4/Escherichia coli bacteria) [63][64][65][66] and biomimetic affinity processes with molecularly imprinted polymers (MIPs) [67], have been implemented (Table 3). …”

Section: Applicationsmentioning

confidence: 99%

“…These kinds of biosensors are for the great majority characterized by the use of biotin as the BRE and the streptavidin as the analyte to be detected in buffer solutions. Marques et al [60] developed a sensor based on an LPG modified with a coating of silica core gold shell (SiO 2 :Au) nanoparticles (NPs), which were deposited using the layer-by-layer method (poly(ally-lamine hydrochloride) (PAH) polycation layer), reaching a LOD of 195 μg l −1 of streptavidin. Wang et al [61], which functionalized a TAP-LPG with adsorption deposition of ionic self-assembled multilayers (ISAMs), used a multi-layer deposition, too.…”

Section: Ofg-based Biosensing Based On Other Bresmentioning

confidence: 99%

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Biosensing with optical fiber gratings

et al. 2017

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Optical fiber gratings (OFGs), especially longperiod gratings (LPGs) and etched or tilted fiber Bragg gratings (FBGs), are playing an increasing role in the chemical and biochemical sensing based on the measurement of a surface refractive index (RI) change through a label-free configuration. In these devices, the electric field evanescent wave at the fiber/surrounding medium interface changes its optical properties (i.e. intensity and wavelength) as a result of the RI variation due to the interaction between a biological recognition layer deposited over the fiber and the analyte under investigation. The use of OFG-based technology platforms takes the advantages of optical fiber peculiarities, which are hardly offered by the other sensing systems, such as compactness, lightness, high compatibility with optoelectronic devices (both sources and detectors), and multiplexing and remote measurement capability as the signal is spectrally modulated. During the last decade, the growing request in practical applications pushed the technology behind the OFG-based sensors over its limits by means of the deposition of thin film overlays, nanocoatings, and nanostructures, in general. Here, we review efforts toward utilizing these nanomaterials as coatings for high-performance and low-detection limit devices. Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical applications. While high-performance metrics are starting to be achieved experimentally, there are still open questions pertaining to an effective and reliable detection of small molecules, possibly up to single molecule, sensing in vivo and multi-target detection using OFG-based technology platforms.

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Section: Applicationsmentioning

confidence: 99%

Section: Ofg-based Biosensing Based On Other Bresmentioning

confidence: 99%

Biosensing with optical fiber gratings

et al. 2017

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“…The dual-peak LPG (dLPG) operating near the dispersion turning point owns intrinsic high sensitivity to the change of surrounding-medium refractive index (SRI) (Shu et al, 2002;Chen et al, 2007). The coating of thin film induces strong changes on the LPG transmission properties (Marques et al, 2016;Villar et al, 2005;Cusano et al, 2005;Pilla et al, 2012). Various fiber optic biosensors have been produced for the detection of protein (Lepinay et al, 2014), bioaffinity of antibody-antigen (Chiavaioli et al, 2014;DeLisa et al, 2000;He et al, 2011), DNA hybridization (Chen et al, 2007;Yin et al, 2013), cellular behavior (Shevchenko et al, 2014), enzyme-glucose binding (Deep et al, 2012;Luo et al, 2014), biotin-streptavidin (Voisin (Brzozowska et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

107

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We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability. The surface morphology of GO overlay was characterized by Atomic force microscopy, Scanning electron microscope, and Raman spectroscopy. By depositing the GO with a thickness of 49.2 nm, the sensitivity in refractive index (RI) of dLPG was increased to 2538 nm/RIU, 200% that of non-coated dLPG, in low RI region (1.333-1.347) where bioassays and biological events were usually carried out. The IgG was covalently immobilized on GO-dLPG via EDC/NHS heterobifunctional cross-linking chemistry leaving the binding sites free for target analyte recognition. The performance of immunosensing was evaluated by monitoring the kinetic bioaffinity binding between IgG and specific anti-IgG in real-time. The GO-dLPG based biosensor demonstrates an ultrahigh sensitivity with limit of detection of 7 ng/mL, which is 10-fold better than non-coated dLPG biosensor and 100-fold greater than LPG-based immunosensor. Moreover, the reusability of GO-dLPG biosensor has been facilitated by a simple regeneration procedure based on stripping off bound anti-IgG treatment. The proposed ultrasensitive biosensor can be further adapted as biophotonic platform opening up the potential for food safety, environmental monitoring, clinical diagnostics and medical applications.

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“…However, some applications require refractometric sensors for water-based environments, which refractive index is around 1.33. The association of LPG with LSPR can provide increased sensitivity and dynamic range to these sensors, apart from chemical and biological selectivity 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Effects from detuning the resonant coupling between fiber gratings and localized surface plasmons

et al. 2016

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In this work, we demonstrate the effect of detuning the resonant coupling between a long period grating and the plasmonic band of gold nanoparticles on the device sensitivity. In an intensity coded configuration, the sensitivity was measured at 568.12 nm and 598.62 nm, for surroundings refractive indexes ranging from 1.3629 to 1.4184. A comparison between the responses of the two dips centered at these wavelengths resulted in a sensitivity enhancement of about 17 times for the dip localized close to the center of the localized surface plasmon resonance.

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Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles

Cited by 54 publications

References 27 publications

Biosensing with optical fiber gratings

Biosensing with optical fiber gratings

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Effects from detuning the resonant coupling between fiber gratings and localized surface plasmons

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