Highly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N‐vinyl‐2‐pyrrolidone)‐Capped Platinum Nanoparticles

Ji, Xudong; Lau, Ho Yuen; Ren, Xiaochen; Peng, Boyu; Zhai, Peng; Feng, Shien-Ping; Chan, Paddy K. L.

doi:10.1002/admt.201600042

Cited by 76 publications

(73 citation statements)

References 33 publications

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“…In addition to carbon based materials, NM of noble metals having size dependent fascinating optical, electro‐magnetic, and chemical properties have been comprehensively followed not only for their important technical contemplation, but also for their numerous industrial applications . NP of metals, particularly gold , silver, and platinum, are among the utmost comprehensively considered NM in the design of sensors for clinical diagnosis, bio‐imaging, and targeted drug delivery . It is due to their oxide‐free surface, ease of conjugation with biological entities, great compatibility with biological counterparts, and exceptional opto‐electronic properties .…”

Section: Noble Metal Npmentioning

confidence: 99%

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

et al. 2019

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The design and development of modern biosensors for sensitive and selective detection of various biomarkers is important in diversified arenas including healthcare, environment, and food industries etc. The requirement of more robust and reliant biosensors lead to the development of various sensing modules. The nanomaterials having specific optical, electrical, and mechanical strength can pave the way towards development of ultrafast, robust, and miniaturized modules for biosensors. It can provide not only the point‐of‐care applicability but also has tremendous commercial as well as industrial justification. In order to improve the performance of the sensor systems, various nanostructure materials have been readily studied and applied for development of novel biosensors. In the last few years, researchers are engaged on harnessing the unique atomic and molecular properties of advance‐engineered materials including carbon nanotubes, graphene nanosheets, metal nanoparticles, metal oxide nanoparticles, and their nano‐conjugates. In view of such recent developments in nanomaterial engineering, the current review has been formulated emphasizing the role of these materials in surface engineering, biomolecule conjugation, and signal amplification for development of various ultrasensitive and robust biosensors having commercial as well as industrial viability. Attention is given on the electrochemical biosensors incorporating various nanomaterials and their conjugates. Importance of nanomaterials in the analytical performance of the various biosensor has also been discussed. To put a perceptive insights on the importance of various nanomaterials, an extended table is incorporated, which includes probe design, analyte, LOD, and dynamic range of various electrochemical biosensors.

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Section: Noble Metal Npmentioning

confidence: 99%

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

et al. 2019

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“…Chitosan modified paper‐based MF colorimetric biosensor was fabricated that could efficiently detect glucose in tears (2 μL) . Ji et al fabricated MF integrated organic electrochemical transistors biosensor for multi‐analytes (glucose and lactate) detection in saliva biofluid . This MF device has a thickness of 100 nm and requires 30 μL of biofluid for analysis.…”

Section: Microfluidics For Non‐invasive Biosensorsmentioning

confidence: 99%

Microfluidics Based Point‐of‐Care Diagnostics

Pandey

Augustine

Kumar

et al. 2017

Biotechnology Journal

208

124

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Point-of-care (POC) diagnostic devices have been predicted to provide a boon in health care especially in the diagnosis and detection of diseases. POC devices have been found to have many advantages like a rapid and precise response, portability, low cost, and non-requirement of specialized equipment. The major objective of a POC diagnostic research is to develop a chipbased, self-containing miniaturized device that can be used to examine different analytes in complex samples. Further, the integration of microfluidics (MF) with advanced biosensor technologies is likely to result in improved POC diagnostics. This paper presents the overview of the different materials (glass, silicon, polymer, paper) and techniques for the fabrication of MF based POC devices along with their wide range of biosensor applications. Besides this, the authors have presented in brief the challenges that MF is currently facing along with possible solutions that may result in the availability of the accessible, reliable, and cost-efficient technology. The development of these devices requires the combination of developed MF components into POC devices that are user-friendly, sensitive, stable, accurate, low cost, and minimally invasive. These MF based POC devices have tremendous potential in providing improved healthcare including easy monitoring, early detection of disease, and increased personalization.

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“…The detection range of the printed sensors extended from 0.1 to 2.3 mM, i.e., the low end of the level range of lactate in sweat, the high end of the range only being accessible by dilution. The modification of the gate electrode of an OECT with poly(N-vinyl-2-pyrrolidone)-capped platinum nanoparticles (PtNPs) was reported to enhance the sensitivity and to improve the detection limit of glucose and lactate down to 10 −7 and 10 −6 M, respectively [133]. The authors also developed a multisensing device by integrated two single OECTs with two separate microfluidic channels in one chip to reduce the volume of analyte and increase the detection speed.…”

Section: Lactatementioning

confidence: 99%

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

et al. 2018

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Featured Application: Sensing organic molecules in water.Abstract: This review first recalls the basic functioning principles of organic electrochemical transistors (OECTs) then focuses on the transduction mechanisms applicable to OECTs. Materials constituting the active semiconducting part are reviewed, from the historical conducting polymers (polyaniline, polypyrrole) to the actual gold standard, poly-3,4-ethylenedioxythiophene: polystyrene sulfonic acid (PEDOT:PSS), as well as the methods used to fabricate these transistors. The review then focuses on applications of OECTs for the detection of small molecules and more particularly of metabolites, with a distinction between enzymatic and non-enzymatic transduction pathways. Finally, the few patents registered on the topic of OECT-based biosensors are reviewed, and new tracks of improvement are proposed. applied to biosensing quite early, associated with enzymes [4][5][6]. This is because, due to their functioning mechanism (already identified at the time), they brought into play the same charge carriers as most biological functions, i.e., electrons but also ions, and were therefore sensitive both to electron transfer to/from redox enzymes or ions (e.g., protons) produced from other types of enzymes. This is a characteristic which distinguished them from organic field-effect transistors (OFETs), which started to raise the attention of researchers exactly at the same period (precisely, 1983 for the first polyacetylene-based OFET [7]), and a few years later for applications to gas sensing (halogens, ammonia, oxygen [8-10] or even vapors of H 2 O, NO or H 2 O 2 [11][12][13][14]). However, OFETs never really produced any applicable results in the framework of biosensors in aqueous environment because of high operating voltages, of several tens of volts, which impede any measurements because of water electrolysis. Ion-sensitive organic field-effect transistors (ISOFETs), based on the same working principles of their inorganic counterparts (ISFETs) developed earlier [15,16], solved this problem of high operating potential, the electrolyte being not in direct contact with the semiconductor. However, these devices were confined mostly to protons detection [17][18][19] or, in any case, to charged species.As we show in this review, OECTs use both potentiometry and amperometry in their working principles. In that sense, OECTs are devices that represent a bridge between ISOFETs and classical amperometry, which certainly explains their success. This area of research is very active and several reviews have already been published on OECTs in general, for example by Kergoat et al. [1] or Rivnay et al. [3], or on OECTs applied to biology, for example by Liao and Yan [20], Liao et al. [21], Strakosas et al. [22] or . This present review, after going back to the basic functioning principles, along with details on transductions applicable to OECTs, reviews materials, fabrication techniques and then sensing applications. We focus on the detection of small molecules and more part...

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Highly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N‐vinyl‐2‐pyrrolidone)‐Capped Platinum Nanoparticles

Cited by 76 publications

References 33 publications

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

Microfluidics Based Point‐of‐Care Diagnostics

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

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