Highly Sensitive Electrochemical Biosensor Using Folic Acid-Modified Reduced Graphene Oxide for the Detection of Cancer Biomarker

Bai, Renu Geetha; Muthoosamy, Kasturi; Tuvikene, Rando; Ming, Huang Nay; Manickam, Sivakumar

doi:10.3390/nano11051272

Cited by 32 publications

(17 citation statements)

References 86 publications

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“…Among the materials that are frequently used for the fabrication of biosensors, the most studied ones are conducting polymers [ 164 ], gold nanoparticles [ 165 ], gold nanorods [ 166 ], and carbonaceous materials (multiwalled carbon nanotubes, graphene oxide, mesoporous carbon etc.) [ 167 , 168 , 169 , 170 ]. The sensing element can be represented by antibodies [ 171 ], DNA [ 172 ], or enzymes [ 173 , 174 , 175 , 176 ].…”

Section: Biomedical and Environmental Applications Of Polyelectrolyte Multilayersmentioning

confidence: 99%

Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications

Petrila¹,

Bucătariu

Mihai

et al. 2021

Materials

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Polyelectrolyte multilayers are versatile materials that are used in a large number of domains, including biomedical and environmental applications. The fabrication of polyelectrolyte multilayers using the layer-by-layer technique is one of the simplest methods to obtain composite functional materials. The properties of the final material can be easily tuned by changing the deposition conditions and the used building blocks. This review presents the main characteristics of polyelectrolyte multilayers, the fabrication methods currently used, and the factors influencing the layer-by-layer assembly of polyelectrolytes. The last section of this paper presents some of the most important applications of polyelectrolyte multilayers, with a special focus on biomedical and environmental applications.

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Section: Biomedical and Environmental Applications Of Polyelectrolyte Multilayersmentioning

confidence: 99%

Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications

Petrila¹,

Bucătariu

Mihai

et al. 2021

Materials

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“… 102 Several research teams have made great efforts to detect lymphoma and MM based on the electrochemical biosensors. 76 – 79 , 87 …”

Section: Applications Of Electrochemical Biosensors In Lymphoma and MMmentioning

confidence: 99%

“…Aiming at these biological molecules, Lou et al 77 constructed a competitive electrochemical immunosensor for the detection of IL-6 based on ERGO-AuPdNPs-Ab 1 and AgNPs-Ab 2 probes. Moreover, Geetha et al 78 developed a novel electrochemical immunosensor for FR detection, adopting FA-modified RGO nanosheets as the substrate. Through the covalent immobilization of HSP70 antibodies on GO as a bio-recognition element, Ozcan and Sezginturk 79 proposed a label-free immunosensor to analyze HSP70 via electrochemical methods such as CV and AC impedance.…”

Section: Applications Of Electrochemical Biosensors In Lymphoma and MMmentioning

confidence: 99%

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Sun

Huang

Wang

et al. 2022

Technol Cancer Res Treat

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Hematological malignancies encompass a wide variety of severe diseases that pose a serious threat to human health. Given the fact that hematological malignancies are difficult to treat due to their unpredictable and rapid deterioration and high rates of recurrence, growing attention has been paid to their early screening and diagnosis. However, developing a rapid and effective diagnostic tool featuring a noninvasive sampling technique is still extremely challenging. In recent years, novel nanomaterials-based electrochemical biosensors have attracted great interest because of such advantages as simple operation, low cost, fast response, etc. As a kind of rising nanomaterials, two-dimensional materials have excellent electronic and chemical properties, which have been proven to improve the performance of electrochemical biosensors. This review summarizes the applications of different types of electrochemical biosensors (nucleic acid sensors, immunosensors, aptamer biosensors, and cytosensors) based on two-dimensional materials in the detection of biological molecules related to hematological malignancies. Two-dimensional materials-based electrochemical biosensors designed for the diagnosis of leukemia could rapidly detect the target biomolecules at a trace level and show great merits such as wide linear range, low detection limit, high sensitivity, excellent selectivity, and cost-effectiveness. In addition, these biosensors have also achieved satisfactory results in the diagnosis of lymphoma and multiple myeloma. Thus, two-dimensional materials-based electrochemical biosensors are attractive for the early diagnosis of hematological malignancies in clinical practice. Nevertheless, more efforts are still required to further improve the performance of electrochemical biosensors. In this review, we propose the possible main concerns in the design of future two-dimensional materials-based electrochemical biosensors, involving the development of sensors for synchronous detection of diverse target biomolecules, the exploration of other superior two-dimensional materials, the simplification of the sensors fabrication process, the construction of new hybrid structures and how to avoid possible environmental issues.

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“…One of the latest trends in clinical diagnostics regards the possibility to develop biosensors capable of detecting cancer biomarkers in the early stages, aiming at preventing cancer-related deaths significantly. In this context, very recently, Bai et al [125] functionalized rGO with folic acid molecules, via π-π complexation, with the purpose to gather the excellent targeting features of folic acid with the electrocatalytic performance of graphene into a unique electrochemical sensing platform. The reaction between GO and folic acid was successfully performed in DMSO/water solution at pH 7 for 12 h at 37 • C. Such relatively inexpensive nanohybrid material demonstrated high sensitivity to a cancer biomarker, with current responses in a linear concentration range from 6 to 100 pM and a detection limit of 1.69 pM.…”

Section: Sensorsmentioning

confidence: 99%

An Overview of Functionalized Graphene Nanomaterials for Advanced Applications

et al. 2021

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Interest in the development of graphene-based materials for advanced applications is growing, because of the unique features of such nanomaterials and, above all, of their outstanding versatility, which enables several functionalization pathways that lead to materials with extremely tunable properties and architectures. This review is focused on the careful examination of relationships between synthetic approaches currently used to derivatize graphene, main properties achieved, and target applications proposed. Use of functionalized graphene nanomaterials in six engineering areas (materials with enhanced mechanical and thermal performance, energy, sensors, biomedical, water treatment, and catalysis) was critically reviewed, pointing out the latest advances and potential challenges associated with the application of such materials, with a major focus on the effect that the physicochemical features imparted by functionalization routes exert on the achievement of ultimate properties capable of satisfying or even improving the current demand in each field. Finally, current limitations in terms of basic scientific knowledge and nanotechnology were highlighted, along with the potential future directions towards the full exploitation of such fascinating nanomaterials.

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Highly Sensitive Electrochemical Biosensor Using Folic Acid-Modified Reduced Graphene Oxide for the Detection of Cancer Biomarker

Cited by 32 publications

References 86 publications

Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications

Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

An Overview of Functionalized Graphene Nanomaterials for Advanced Applications

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