Highly Sensitive Diagnosis of Extracellular Calcium Ions Associated Brain Diseases using Ca2+‐Dependent T2‐T1 Switchable Magnetic Nanosensors
Qiyue Wang,
Tao Wang,
Shengfei Yang
et al.
Abstract:Calcium ions (Ca2+) play crucial roles as second messengers in living cells and are associated with the onset and development of chronic brain diseases, including epilepsy. Dynamic and real‐time imaging of extracellular calcium levels ([Ca2+]ex) in the brain holds great potential for identifying disease foci. Magnetic resonance imaging (MRI) is a powerful non‐invasive tool for Ca2+ imaging with unlimited depth penetration. However, current available Ca2+ MR sensors lack the sensitivity to monitor small [Ca2+]e… Show more
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