Highly sensitive determination of <scp>l</scp>-glutamic acid in pig serum with an enzyme-free molecularly imprinted polymer on a carbon-nanotube modified electrode

Yu, Xin-Yao; He, Jun-Yi; Tang, Fei; Yu, Peng; Wu, Ling; Xiao, Zhong-Liang; Sun, Li-Xian; Cao, Zhong; Yu, Donghong

doi:10.1039/d3ay01499a

Cited by 1 publication

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“…Recently, Li and coworkers combined a molecularly imprinted poly(o-phenylenediamine) with multi-walled carbon nanotubes (MWCNTs), chitosan and β-cyclodextrin to produce an electrochemical sensor for the enantiomeric detection of L-tryptophan resulting in a limit of detection of 0.5 µM and a good recovery estimation in spiked milk samples [58]. Given the outstanding electrocatalytic properties of MWNCTs [59,60], such excellent material was further exploited in combination with molecular imprinting technology in the work of Yu et al, where a selective electrochemical sensor was constructed for the nanomolar detection of glutamic acid and its sensing in pig serum samples, results that were additionally corroborated by HPLC analysis [61].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Gagliani,

Di Giulio,

Grecchi

et al. 2024

Molecules

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An environmentally friendly and sustainable approach was adopted to produce a molecularly imprinted polymer (MIP) via electropolymerization, with remarkable electrochemical sensing properties, tested in tyrosine (tyr) detection. The 2,2′-bis(2,2′-bithiophene-5-yl)-3,3′-bithianaphtene (BT2-T4) was chosen as functional monomer and MIP electrosynthesis was carried out via cyclic voltammetry on low-volume (20 μL) screen-printed carbon electrodes (C-SPE) in ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ((BMIM) TFSI). An easy and rapid washing treatment allowed us to obtain the resulting MIP film, directly used for tyr electrochemical detection, carried out amperometrically. The sensor showed a linear response in the concentration range of 15–200 μM, with LOD of 1.04 µM, LOQ of 3.17 μM and good performance in selectivity, stability, and reproducibility. Tyrosine amperometric detection was also carried out in human plasma, resulting in a satisfactory recovery estimation. The work represents the first use of BT2-T4 as a functional monomer for the production of a molecularly imprinted polymer, with a green approach afforded by using a few microliters of a room temperature ionic liquid as an alternative to common organic solvents on screen-printed carbon electrodes, resulting in a valuable system that meets the green chemistry guidelines, which is today an essential criterion in both research and application field.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Gagliani,

Di Giulio,

Grecchi

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Highly sensitive determination of l-glutamic acid in pig serum with an enzyme-free molecularly imprinted polymer on a carbon-nanotube modified electrode

Abstract: Through electrochemical polymerization using L-glutamic acid (L-Glu) as a template and 4,6-diaminoresorcinol as a functional monomer, an enzyme-free molecularly imprinted polymer (MIP) based L-Glu sensor with multi-walled carbon nanotubes (MWCNTs)...

Cited by 1 publication

References 62 publications

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

Green Synthesis of a Molecularly Imprinted Polymer Based on a Novel Thiophene-Derivative for Electrochemical Sensing

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