Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry

Zhu, Quan-Fei; Yan, Jingwen; Gao, Yang; Zhang, Jingwei; Feng, Yu‐Qi; Feng, Yun

doi:10.1016/j.jchromb.2017.06.045

Cited by 49 publications

(66 citation statements)

References 19 publications

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“…The term FAHFAw as introduced [1] by the Kahn team in 2014 to coin the new class of endogenous lipids with antidiabetic properties that they uncovered in adipose tissues.S ince then, branched FAHFAs were found in blood and in many tissues (white (WAT)a nd brown (BAT) adipose tissues, liver, heart, pancreas, kidneys, lungs, thymus) in humans andr odents [1,2,4,7] (Tables1-2). Av ery recent study also shows the presence of FAHFAs in human breast milk.…”

Section: Fahfas Are Endogenous Lipidsmentioning

confidence: 99%

“…Major FAHFAs are combination of palmitic acid (PA), stearic acid (SA), oleic acid (OA), or palmitoleic acid (PO) with their corresponding hydroxyl fatty acids (HFA: HPA, HAS, HOA, HPO respectively), providing PAHPA, OAHPA, PAHOA, OAHOA, PAHSA and OAHSA (Table 1). [1,2,7] Amongt he observed 16 FAHFAf amilies, Yore et al detected ag reat number of regioisomers. [1] Mass fragmentation allowed the identification of isomersw ith the ester linkagea tp osition C5, C7, C8, C10, C11, C12 and C13.…”

Section: Fahfas Are Endogenous Lipidsmentioning

confidence: 99%

“…The levels of PAHSA major esters are regulated in mice and humans by physiological and physio-pathological conditions [1,5,7,18,19] such as fasting,r efeeding, obesity,i nsulin resistance and cancer.T his regulation is tissue-specific. [1,18] For instance,l evels of PAHSAs in white adipose tissue increasei n mice during fasting and normalize with refeeding, while these levels do not change in the liver and even decrease slightly with fastingi nb lood.…”

Section: Regulation Of Fahfas Levels In Altered Metabolic Statesmentioning

confidence: 99%

“…Severalt eams developed liquid chromatography-tandem mass spectrometry (LC-MS, LCMS/MSo rL C-MS 3 )c onditions. [1][2][3][4][5][6][7][8] This will not be discussed in this review but readers interested in in vivo FAHFAs detection are encouraged to refer to recent articles.The case of the "omega-FAHFA", that is, fatty acyl esters of omega-hydroxyf atty acids, (also called "linear" FAHFAi nc omparisonw ith the branchedF AHFA) is not included in the present review,b ut can be found in significant amounts in human meibomian gland secretions. [9][10][11][12][13] Scheme17.…”

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confidence: 99%

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confidence: 99%

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Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type‐2 Diabetes

Balas

Feillet‐Coudray

Durand

2018

Chemistry A European J

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After a brief overview of the biological significance of FAHFAs, the present Minireview highlights the different strategies developed for their chemical syntheses. The term "FAHFAs" has been introduced in 2014 for fatty acyl esters of hydroxyl fatty acids, found in adipocytes, with antidiabetic properties. However, many other natural products contain this type of branched lipids in their structure. This review was then extended to the synthesis of these subunits, even though the length of the lipid chains and the location of the ester linkages are different, since the developed strategies may be applied to the synthesis of "FAHFA".

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Section: Fahfas Are Endogenous Lipidsmentioning

confidence: 99%

Section: Fahfas Are Endogenous Lipidsmentioning

confidence: 99%

Section: Regulation Of Fahfas Levels In Altered Metabolic Statesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type‐2 Diabetes

Balas

Feillet‐Coudray

Durand

2018

Chemistry A European J

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Structural Characterization of Lipids Using Advanced Mass Spectrometry Approaches

Cvačka¹,

Vrkoslav²,

Strnad³

2023

Mass Spectrometry for Lipidomics

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Chemical derivatization strategy for mass spectrometry‐based lipidomics

Xia

Wan

2021

Mass Spectrometry Reviews

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Lipids, serving as the structural components of cellular membranes, energy storage, and signaling molecules, play the essential and multiple roles in biological functions of mammals. Mass spectrometry (MS) is widely accepted as the first choice for lipid analysis, offering good performance in sensitivity, accuracy, and structural characterization. However, the untargeted qualitative profiling and absolute quantitation of lipids are still challenged by great structural diversity and high structural similarity. In recent decade, chemical derivatization mainly targeting carboxyl group and carbon-carbon double bond of lipids have been developed for lipidomic analysis with diverse advantages: (i) offering more characteristic structural information; (ii) improving the analytical performance, including chromatographic separation and MS sensitivity; (iii) providing one-toone chemical isotope labeling internal standards based on the isotope derivatization regent in quantitative analysis. Moreover, the chemical derivatization strategy has shown great potential in combination with ion mobility mass spectrometry and ambient mass spectrometry. Herein, we summarized the current states and advances in chemical derivatization-assisted MS techniques for lipidomic analysis, and their strengths and challenges are also given. In summary, the chemical derivatization-based lipidomic approach has become a promising and reliable technique for the analysis of lipidome in complex biological samples.

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Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry

Cited by 49 publications

References 19 publications

Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type‐2 Diabetes

Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type‐2 Diabetes

Structural Characterization of Lipids Using Advanced Mass Spectrometry Approaches

Chemical derivatization strategy for mass spectrometry‐based lipidomics

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