Highly sensitive biosensor based on graphene–poly (3-aminobenzoic acid) modified electrodes and porous-hollowed-silver-gold nanoparticle labelling for prostate cancer detection

Pothipor, Chammari; Wiriyakun, Natta; Putnin, Thitirat; Ngamaroonchote, Aroonsri; Jakmunee, Jaroon; Ounnunkad, Kontad; Laocharoensuk, Rawiwan; Aroonyadet, Noppadol

doi:10.1016/j.snb.2019.126657

Cited by 47 publications

(19 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Silver nanoparticles have a special role in modern anticancer therapy, being explored for detection and diagnosis of malignant tumors [ 232 , 233 ], controlled and externally triggered drug delivery systems [ 234 , 235 ]. In a similar way with the antimicrobial activity of AgNPs, their efficiency against cancer cells require the cellular uptake of nanosilver, which can be acquired by diffusion, phagocytosis, pinocytosis and receptor-mediated endocytosis [ 236 , 237 ].…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

show abstract

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Their electrode composed of core-shell hollowed-porous-gold-silver nanoparticles (PHSGNPs) and graphene-poly (3-aminobenzoic acid) (GP-P3ABA) (Figure 10). Based on their tests, the sensing efficiency is improved by 120 folds over AuNP labeling and the detection limit (LOD) in human serum hits 0.13 pg/mL or four orders of magnitude better than the clinically appropriate level [175]. the first impedance and electrochemically-based nanosensors which are able to detect PCA3 as low as 0.128 nmol/L.…”

Section: Graphenementioning

confidence: 99%

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

et al. 2020

View full text Add to dashboard Cite

The fabrication and development of nanomaterials for the treatment of prostate cancer have gained significant appraisal in recent years. Advancements in synthesis of organic and inorganic nanomaterials with charge, particle size, specified geometry, ligand attachment etc have resulted in greater biocompatibility and active targeting at cancer site. Despite all of the advances made over the years in discovering drugs, methods, and new biomarkers for cancer of the prostate (PCa), PCa remains one of the most troubling cancers among people. Early on, effective diagnosis is an essential part of treating prostate cancer. Prostate-specific antigen (PSA) or serum prostate-specific antigen is the best serum marker widely accessible for diagnosis of PCa. Numerous efforts have been made over the past decade to design new biosensor-based strategies for biomolecules detection and PSA miniaturization biomarkers. The growing nanotechnology is expected to have a significant effect in the immediate future on scientific research and healthcare. Nanotechnology is thus predicted to find a way to solve one of the most and long-standing problem, “early cancer detection”. For early diagnosis of PCa biomarkers, different nanoparticles with different approaches have been used. In this review, we provide a brief description of the latest achievements and advances in the use of nanoparticles for PCa biomarker diagnosis.

show abstract

“…The LODs were 0.01 U mL −1 , 0.01 U mL −1 , and 1 pg mL −1 , respectively. In another study for PSA detection, a nanomaterial–conductive polymer nanocomposite, graphene-poly(3-aminobenzoic acid) (GP-P3ABA), was used for electrode modification and porous-hollowed-silver-gold core–shell nanoparticles (PHAu shell -Ag core NPs) amplified the signals by acting as labels in the system [200]. A 3-fold current response was obtained for PHAg core -Au shell NPs against pure AuNPs.…”

Section: Applications Of Inorganic Nanomaterials In Healthcare Biomentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

166

View full text Add to dashboard Cite

In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

show abstract

Highly sensitive biosensor based on graphene–poly (3-aminobenzoic acid) modified electrodes and porous-hollowed-silver-gold nanoparticle labelling for prostate cancer detection

Cited by 47 publications

References 54 publications

An Updated Review on Silver Nanoparticles in Biomedicine

An Updated Review on Silver Nanoparticles in Biomedicine

Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates

Nanomaterials for Healthcare Biosensing Applications

Contact Info

Product

Resources

About