Highly sensitive and specific noninvasive in-vivo alcohol detection using wavelength-modulated differential photothermal radiometry

Guo, Xinxin; Shojaei‐Asanjan, Khashayar; Zhang, Di; Sivagurunathan, Koneswaran; Sun, Qiming; Song, Peng; Chen, Bin; Goledzinowski, Matt; Zhou, Qun; Comeau, Felix J. E.

doi:10.1364/boe.9.004638

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Laser output power at pulse duty cycle 5% is ~ 3.4 mW with single wavelength measurements and ~ 6.8 mW with differential wavelength measurements. A quasi‐CW wavelength modulation methodology involving a low‐frequency square‐wave modulation envelope was developed and presented elsewhere , where a tunable QCL switches between peak wavelength (9.6 μm) and baseline wavelength (8.25 μm) at a frequency half the modulation frequency.…”

Section: Methodsmentioning

confidence: 99%

Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength‐modulated differential photothermal radiometry

Guo

Zhang

Shojaei‐Asanjan

et al. 2019

Journal of Biophotonics

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We present a noninvasive and noncontacting biosensor using Wavelength Modulated Differential Photothermal Radiometry (WM‐DPTR) to monitor blood glucose concentration (BGC) through interstitial fluid (ISF) probing in human middle fingers. WM‐DPTR works in the interference‐free mid‐infrared range with differential wavelengths at the peak and baseline of the fundamental glucose molecule absorption band, giving rise to high glucose sensitivity and specificity. In vivo WM‐DPTR measurements and simultaneous finger pricking BGC reference measurements were performed on diabetic and nondiabetic volunteers during oral glucose tolerance testing. The measurement results demonstrated high resolution and large dynamic range (~80 deg) change in phase signal in the normal‐to‐hyperglycemia BGC range (5 mmol/L to higher than 33.2 mmol/L), which were supported by negative control measurements. The immunity to temperature variation of WM‐DPTR yields precise and accurate noninvasive glucose measurements in the ISF.

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Section: Methodsmentioning

confidence: 99%

Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength‐modulated differential photothermal radiometry

Guo

Zhang

Shojaei‐Asanjan

et al. 2019

Journal of Biophotonics

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“…Alternative to NIRS techniques, a method developed by Guo et al [105], used wavelength modulated differential photothermal radiometry (WM-DPTR) to estimate BAC in the mid-infrared range. The WM-DPTR method is based on the modulation of laser-beams which are out-of-phase in respect to each other, where one of the wavelengths is the peak absorption and the other is the baseline for the analyte, in this case ethanol.…”

Section: Optical Spectroscopymentioning

confidence: 99%

Review of Ethanol Intoxication Sensing Technologies and Techniques

Paprocki

Qassem

Kyriacou

2022

Sensors

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The field of alcohol intoxication sensing is over 100 years old, spanning the fields of medicine, chemistry, and computer science, aiming to produce the most effective and accurate methods of quantifying intoxication levels. This review presents the development and the current state of alcohol intoxication quantifying devices and techniques, separated into six major categories: estimates, breath alcohol devices, bodily fluid testing, transdermal sensors, mathematical algorithms, and optical techniques. Each of these categories was researched by analyzing their respective performances and drawbacks. We found that the major developments in monitoring ethanol intoxication levels aim at noninvasive transdermal/optical methods for personal monitoring. Many of the “categories” of ethanol intoxication systems overlap with each other with to a varying extent, hence the division of categories is based only on the principal operation of the techniques described in this review. In summary, the gold-standard method for measuring blood ethanol levels is through gas chromatography. Early estimation methods based on mathematical equations are largely popular in forensic fields. Breath alcohol devices are the most common type of alcohol sensors on the market and are generally implemented in law enforcement. Transdermal sensors vary largely in their sensing methodologies, but they mostly follow the principle of electrical sensing or enzymatic reaction rate. Optical devices and methodologies perform well, with some cases outperforming breath alcohol devices in terms of the precision of measurement. Other estimation algorithms consider multimodal approaches and should not be considered alcohol sensing devices, but rather as prospective measurement of the intoxication influence. This review found 38 unique technologies and techniques for measuring alcohol intoxication, which is testament to the acute interest in the innovation of noninvasive technologies for assessing intoxication.

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Continuously tunable middle-IR bandpass filters based on gradient metal-hole arrays for multispectral sensing and thermography

Chernomyrdin

Lavrukhin

Ulitko

et al. 2022

Journal of Applied Physics

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Continuously tunable middle-infrared bandpass filters have been developed based on gradient metal-hole arrays with two distinct geometries. The rotation filter relies on an array of metal holes with gradually changing periods and hole sizes in the azimuthal direction, while the translation filter exploits a metal-hole array with a linear gradient. The filters are fabricated in a Ti film on a ZnSe substrate using electron-beam nanolithography. They are characterized experimentally using Fourier-transform infrared spectroscopy, and the observed results are compared with numerical predictions of the finite element method. The developed filters offer wide spectral tunability when operating with a focused beam. Particularly, the central wavelength of the transmission band is tunable in the [Formula: see text] range, for the rotation filter, and in the [Formula: see text] range for the translation one, as a linear function of the filter angular or linear displacement. The filters feature relatively broad bandwidths of [Formula: see text], while their spectral contrast and energy efficiency depend on the gradient type. The filter spectral response function shape and the extent of its spectra tunability can be further optimized by judicious design of the hole geometry and the metal-hole array gradient, respectively. The developed filters hold strong potential in the infrared multispectral sensing and imaging, thanks to their conceptual simplicity. Considering the linearity of Maxwell’s equations and availability of appropriate technologies for the fabrication of gradient arrays of sub-wavelength metal holes, the developed concept can be translated to other spectral ranges.

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Highly sensitive and specific noninvasive in-vivo alcohol detection using wavelength-modulated differential photothermal radiometry

Cited by 4 publications

References 13 publications

Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength‐modulated differential photothermal radiometry

Noninvasive in vivo glucose detection in human finger interstitial fluid using wavelength‐modulated differential photothermal radiometry

Review of Ethanol Intoxication Sensing Technologies and Techniques

Continuously tunable middle-IR bandpass filters based on gradient metal-hole arrays for multispectral sensing and thermography

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