Highly sensitive and selective fluorescence and smartphone-based sensor for detection of L-dopa using nitrogen sulphur graphene quantum dots

Duhan, Jyoti; Obrai, Sangeeta

doi:10.1016/j.microc.2023.109262

Cited by 17 publications

(1 citation statement)

References 66 publications

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“…For interference study, fluorescence responses [(I-I 0 )/ I 0 ] of the Fe 2 + @cys@CuNC towards L-DOPA in presence of interfering neurotransmitters and biomolecules was conducted and results are given in Figure 6b. Here, L-DOPA was added to Nitrogen sulphur graphene quantum dots Fluorescence 7.8 nM [41] L/D-tryptophan decorated carbon quantum dots Fluorescence 11.2 nM [22] Ferrous ions incorporated copper nanoclusters (a) UV-Visible absorption spectra of cys@CuNC, Fe 2 + @cys@CuNC and L-DOPA@Fe 2 + @cys@CuNC ([L-DOPA]: 0.06 mM to 1.31 mM); (b) TCSPC decay profile of cys@CuNC, Fe 2 + @cys@CuNC and L-DOPA@Fe 2 + @cys@CuNC; (c) Normalized and merged excitation spectrum of cys@CuNCs, emission spectrum of cys@CuNCs and absorbance spectrum of Fe 2 + .…”

Section: Selectivity and Interference Studiesmentioning

confidence: 99%

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Varghese,

Chandran,

Madanan

et al. 2024

ChemistrySelect

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L‐3,4‐dihydroxyphenylalanine (levodopa or L–DOPA) a precursor of neurotransmitter dopamine, has been universally prescribed as a gold standard for treatment of Parkinson's Disease (PD). However, direct administration of L–DOPA has risky adverse effects which makes it challenging in the treatment of PD. Hence developing simple detection platform for sensing of L–DOPA is significant. In this work, we have developed cysteine stabilized copper nanocluster quenched with Fe2+ (Fe2+@cys@CuNC) and used as both fluorescent and colorimetric probe for detection of L–DOPA. L–DOPA attributed a fluorescence quenching effect on developed probe. Fe2+@cys@CuNC detected L–DOPA within a linear range from 0.06 mM to 1.31 mM with a low limit of detection (LoD) of 6.57 nM. The probe also exhibited high selectivity for L–DOPA over other biomolecules and neurotransmitters. Furthermore, the capability of this probe was validated by sensing L–DOPA from human serum with excellent recovery rates of 85.75 % to 115.07 %. A low‐cost paper strip‐based portable detection platform was also developed for visual detection of L–DOPA.

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Section: Selectivity and Interference Studiesmentioning

confidence: 99%