Highly sensitive and selective detection of dopamine in the presence of ascorbic acid at graphene oxide modified electrode

Gao, Feng; Cai, Xili; Wang, Xia; Gao, Cai; Liu, Shaoli; Gao, Fei; Wang, Qingxiang

doi:10.1016/j.snb.2013.06.020

Cited by 301 publications

(135 citation statements)

References 45 publications

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“…The detection limit was smaller than some previous reported works such as Ni/Al layered double hydroxide modified carbon ionic liquid electrode (5.0× 10 -6 mol L -1 ), [29] PtAu hybrid film modified GCE (5.0× 10 -6 mol L -1 ), [30] and GR modified GCE (2.64× 10 -6 mol L -1 ), [31] GR and Au nanoparticles modified GCE (1.86× 10 -6 mol L -1 ), [32] TiO2-GR modified GCE (2.0× 10 -6 mol L -1 ), [33] and graphene oxide modified GCE (0.27× 10 -6 mol L -1 ). [34] So the presence of NG on the GCE surface exhibited excellent electrocatalytic activity to the oxidation of DA with increased sensitivity.…”

Section: Calibration Curvementioning

confidence: 96%

Sensitive Electrochemical Detection of Dopamine With a Nitrogen-doped Graphene Modified Glassy Carbon Electrode

Wang¹,

Gong²,

Sun³

et al. 2016

Croat. Chem. Acta

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Abstract:In this paper nitrogen-doped graphene (NG) nanosheets were used as the modifier on the surface of glassy carbon electrode (GCE). The modified electrode (NG/GCE) was further applied to the sensitive detection of dopamine (DA) by voltammetric method. Due to the unique properties of NG such as large surface area and excellent electrocatalytic activity, electrochemical response of DA was greatly enhanced on NG/GCE with a pair of well-defined redox peaks appeared on cyclic voltammogram. Electrochemical behaviors of DA on NG/GCE were carefully investigated with the electrochemical parameters calculated. Under the selected conditions the oxidation peak currents of DA had a good linear relationship with its concentration in the range from 8.0 × 10 -7 mol L -1 to 8.0 × 10 -4 mol L -1 with a detection limit of 2.55 × 10 -7 mol L -1 (3σ). The proposed method was further applied to the DA injection samples determination with satisfactory results.

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Section: Calibration Curvementioning

confidence: 96%

Sensitive Electrochemical Detection of Dopamine With a Nitrogen-doped Graphene Modified Glassy Carbon Electrode

Wang¹,

Gong²,

Sun³

et al. 2016

Croat. Chem. Acta

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“…where i pc is the reduction peak current of K 3 In order to explore the effect of electrocatalytic activity on the response peak current, the peak current densities are estimated by dividing by their electrochemical area, aiming to exclude the influence of the electrochemical active area. The peak current densities (J a ) of MnO 2 NWs-RGO/GCE, MnO 2 NRs-RGO/GCE, and MnO 2 NTs-RGO/GCE are listed in the fourth column in Table 1.…”

Section: Electrochemical Active Area Of Mno 2 -Rgo/gcesmentioning

confidence: 99%

“…An abnormal level of dopamine may cause several central nervous system diseases such as depression, anxiety, schizophrenia, and Parkinson's disease [2][3][4][5]. Therefore, it is of great significance to detect dopamine accurately at a physiological level in the earlier prevention and clinical diagnosis of these neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

Liu

et al. 2018

Catalysts

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Abstract:The morphology or shape of nanomaterials plays an important role in functional applications, especially in the electrochemical sensing performance of nanocomposites modified electrodes. Herein, the morphology-dependent electrochemical sensing properties of MnO 2 -reduced graphene oxide/glass carbon electrode (MnO 2 -RGO/GCE) toward dopamine detection were investigated. Firstly, various morphologies of nanoscale MnO 2 , including MnO 2 nanowires (MnO 2 NWs), MnO 2 nanorods (MnO 2 NRs), and MnO 2 nanotubes (MnO 2 NTs), were synthesized under different hydrothermal conditions. Then the corresponding MnO 2 -RGO/GCEs were fabricated via drop-casting and the subsequent electrochemical reduction method. The oxidation peak currents increase with the electrochemical activity area following the order of MnO 2 NWs-RGO/GCE, MnO 2 NTs-RGO/GCE, and MnO 2 NRs-RGO/GCE. The spatial models for MnO 2 NWs, MnO 2 NTs, and MnO 2 NRs are established and accordingly compared by their specific surface area, explaining well the evident difference in electrochemical responses. Therefore, the MnO 2 NWs-RGO/GCE is selected for dopamine detection due to its better electrochemical sensing performance. The response peak current is found to be linear with dopamine concentration in the range of 8.0 × 10 −8 mol/L-1.0 × 10 −6 mol/L and 1.0 × 10 −6 mol/L-8.0 × 10 −5 mol/L with a lower detection limit of 1 × 10 −9 mol/L (S/N = 3). Finally, MnO 2 NWs-RGO/GCE is successfully used for the determination of dopamine injection samples, with a recovery of 99.6-103%. These findings are of great significance for understanding the relationship between unlimited nanoparticle structure manipulation and performance improvement.

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“…A linear dependence of peak potential on pH of the supporting electrolyte was obtained following a linear equation: E/mV = 787.4 -62.64 pH; R 2 = 0.997. The peak potential at 25 ºC is expressed as [32]: E p = Eº -(m/n) 59 pH (2) where, Eº is the standard potential, m and n are the number of protons and electrons respectively. Since the plot of E pa (mV) vs. pH gave a slope of 62.64 mV/pH which is close to the expected value of 59 mV/pH, we can say m/n is 1.…”

Section: Effect Of Supporting Electrolyte and Phmentioning

confidence: 99%

MWCNT-Chitosan-ZrO2 Nanocomposite Modified Sensor for Sensitive and Selective Electrochemical Determination of Serotonin

Devnani¹

2015

IJIRSET

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ABSTRACT:A novel sensitive electrochemical sensor has been developed by modification of glassy carbon electrode (GCE) with multi-walled carbon nanotube (MWCNT), chitosan (CHIT) and zirconium oxide (ZrO 2 ) nanoparticles. The morphological characteristics of nanocomposite (MWCNT-CHIT-ZrO 2 or MCZ) were studied by scanning electron microscope and atomic force microscopy. The electrochemical behavior of serotonin at nanocomposite modified GCE (MCZ/GCE) was investigated in pH 6.5 Briton Robinson buffer solution using cyclic voltammetry and square wave voltammetry. MCZ/GCE showed an enhancement in the current response as compared to bare GCE and showed a linear response to serotonin in the range 800 to 5000 nM. The limit of detection was found to be 0.6 nM, which is lower than many other sensors reported for serotonin in literature. The modified sensor showed high sensitivity (9 nA/nM) and selectivity for serotonin. The proposed method was successfully employed for quantification of serotonin in human blood serum samples.

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Highly sensitive and selective detection of dopamine in the presence of ascorbic acid at graphene oxide modified electrode

Cited by 301 publications

References 45 publications

Sensitive Electrochemical Detection of Dopamine With a Nitrogen-doped Graphene Modified Glassy Carbon Electrode

Sensitive Electrochemical Detection of Dopamine With a Nitrogen-doped Graphene Modified Glassy Carbon Electrode

Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

MWCNT-Chitosan-ZrO2 Nanocomposite Modified Sensor for Sensitive and Selective Electrochemical Determination of Serotonin

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