Highly-sensitive and selective colorimetric sensor for amino acids chiral recognition based on molecularly imprinted photonic polymers

Zhang, Yinxia; Zhao, Pin-Yi; Yu, Li‐Ping

doi:10.1016/j.snb.2013.02.079

Cited by 67 publications

(34 citation statements)

References 38 publications

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“…A multitude of potential methods have been developed for specific and sensitive detection of protein [26,[74][75]. Recently, several molecular imprinted photonic crystal sensors were used for protein detection.…”

Section: Sensing Of Proteinmentioning

confidence: 99%

“…Another MIPCB for amino acids chiral recognition was developed by Yu et al using polystyrene colloids array as sacrificial template. [26] The polymer was composed of AAm, MAA using l-phenylalanine (l-Phe) as template, APS and BIS as initiator and cross-linker, respectively. The reflection wavelength of the MIPCB has a distinct red-shift when l-Pga molecule was bound to the MIPCB with a very short response time of 5 min.…”

Section: Sensing Of Chiral Biomoleculesmentioning

confidence: 99%

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Molecular imprinted photonic crystal for sensing of biomolecules

Chen¹,

Meng²,

Xue³

et al. 2016

Molecular Imprinting

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Molecularly imprinted polymers (MIPs) are highly cross-linked polymers with high binding capacity and selectivity to the target molecules. MIPs become increasingly important because of the potential applications in drug delivery, purification and separation. In spite of the tremendous progress that has been made in the molecular imprinting field, many challenges remain to be addressed, especially in transforming the binding event into a detectable optical signal. The combination of photonic crystal and molecular imprinting technique is becoming a popular research idea. Compared to the conventional MIPs, the molecularly imprinted photonic crystal sensors (MIPCB) have the advantage of directly convert the molecule recognition process into optical signal. This review comprehensively summarizes various MIPCB, including the principle of molecular imprinted photonic crystal sensors, recent development, some challenges and effective strategies for MIPCB.

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Section: Sensing Of Proteinmentioning

confidence: 99%

Section: Sensing Of Chiral Biomoleculesmentioning

confidence: 99%

Molecular imprinted photonic crystal for sensing of biomolecules

Chen¹,

Meng²,

Xue³

et al. 2016

Molecular Imprinting

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“…A colorimetric MIPC sensor was developed by Zhang et al [34] for the sensitive and selective chiral recognition of amino acids. The sensor was fabricated by infiltrating a polystyrene photonic crystal template with precursor and imprinting molecules, followed by a thermal polymerization.…”

Section: Mip-based Bioassay By Measurement Of Diffraction Signals or mentioning

confidence: 99%

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Liu

Huang

et al. 2015

Molecularly Imprinted Polymers in Biotechnology

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In the past five years, significant progress has been made in preparation of various molecularly imprinted polymer (MIP)-based materials for applications in bioassays and biotransformation. This chapter reviews the important advances in these two fields. The first part mainly focuses on the development of various MIP-based bioassays that convert the rebinding of template to the imprinted cavities into measurable luminescent signals, including fluorescence, phosphorescence, Raman scattering, diffraction, and the like. In addition, MIP-based bioassays that are measured by surface plasmon resonance or quartz crystal microbalance are also discussed. In the following part, representative biotransformation reactions that make use of MIPs are summarized. In the last part of this chapter, some remaining challenges are briefly discussed for further development of the two fields.

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“…Therefore, the chiral separation of amino acid enantiomers is of great importance and indispensable in life science fields and in various chemical industries dealing with pharmaceuticals, pesticides, food additives, cosmetics, and so on . Now, there are several chiral resolution methods, such as diastereomer crystallization, preferential crystallization, chemically kinetic resolution, enzymatic kinetic resolution, chromatography and membrane separation . Among them, chiral separation with membranes is a promising method because membrane‐based processes are continuous, eco‐friendly, economical and are easy to scale up …”

Section: Introductionmentioning

confidence: 99%

Preparation of molecule imprinted membrane of single enantiomer of amino acid with an innovative strategy and study on its chiral recognition and resolution properties

Gao

Cui

2017

J. Chem. Technol. Biotechnol

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BACKGROUND The molecularly imprinted membranes (MIMs) with high performance are very valuable in the chiral resolution of amino acids. In this work, a novel molecularly imprinted membrane of the single enantiomer of amino acids with graft type was successfully prepared by using an advanced surface imprinting technique. The aminated microfiltration membrane of polysulfone, AMPSF membrane, was first prepared, and so a surface‐initiating system of ‐NH2/S2O8‐ was constituted. In an aqueous solution, the molecules of dimethylaminoethyl methacrylate (DMAEMA) as functional monomer were combined around L‐glutamic acid (L‐Glu) as template by right of electrostatic interaction and hydrogen bonding. By initiating of ‐NH2/S2O8‐ system, DMAEMA and the crosslinking agent N,N′‐Methylenebisacrylamide (MBA) produced graft/crosslinking‐polymerization on the surface of AMPSF membrane, whereas L‐Glue molecules were wrapped within the grafted polymer layer, obtaining grafting type L‐Glue molecule‐imprinted membrane (L‐Glue‐MIM). The ability of the chiral recognition and enantioseparation of L‐Glue‐MIM were examined. RESULTS The experimental results show that L‐Glue‐MIM possesses specific chiral recognition selectivity and excellent enantioseparation ability. In the permeation experiment, L‐Glue molecules in the raceme solution can smoothly pass across L‐Glue‐MIM, but D‐Glue molecules are seriously blocked. As a result, Glu raceme solution is well separated, and the optical purity (ee value) of the penetrating fluid gets up to 82%. CONCLUSION Grafting type molecularly imprinted membrane of the single enantiomer of amino acids was successfully prepared by using an innovative and advanced surface‐imprinting technique of “synchronously graft‐polymerizing and molecule imprinting”, and it supplies a newer route to prepare imprinted membrane with high performance for chiral resolution of amino acids and other chiral drugs. Such study is reported for the first time. © 2017 Society of Chemical Industry

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Highly-sensitive and selective colorimetric sensor for amino acids chiral recognition based on molecularly imprinted photonic polymers

Cited by 67 publications

References 38 publications

Molecular imprinted photonic crystal for sensing of biomolecules

Molecular imprinted photonic crystal for sensing of biomolecules

Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation

Preparation of molecule imprinted membrane of single enantiomer of amino acid with an innovative strategy and study on its chiral recognition and resolution properties

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