Highly sensitive analytical method for the accurate determination of 5-methyltetrahydrofolic acid monoglutamate in various volumes of human plasma using isotope dilution ultra-high performance liquid chromatography-mass spectrometry

Hyung, Seok‐Won; Lee, Sun Young; Han, Jeesoo; Lee, Joon‐Hee; Beak, Song-Yee; Kim, Byung-Joo; Choi, Kiwhan; Ahn, Seonghee

doi:10.1016/j.jchromb.2021.122725

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…46–48 However, LC-MS-based metabolic analysis usually requires pre-treatment to remove the proteins and salts. 49 The tedious sample pre-treatments (at least 1–3 hours for each sample) are indispensable. These time-consuming procedures may cause sample information loss and high overhead, hindering their clinical application.…”

Section: Resultsmentioning

confidence: 99%

Hollow multishelled heterostructures with enhanced performance for laser desorption/ionization mass spectrometry based metabolic diagnosis

Pei

et al. 2023

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Hollow multishelled heterostructures with enhanced performance for laser desorption/ionization mass spectrometry based metabolic diagnosis

Pei

et al. 2023

J. Mater. Chem. B

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Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

Chen

Shu

Zhao

et al. 2022

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In vitro diagnosis (IVD) is one vital component of medical tests that detects biological samples of tissues or bio‐fluids. Recently, mass spectrometry and spectroscopy have been increasingly employed in the field of IVD, due to their high accuracy, facile sample preparation, and rapid detection. Notably, the large datasets generated by these two technology methods provide a wealth of information but subsequently involve complex and time‐consuming processing works. Machine learning (ML), an important branch of artificial intelligence (AI), has emerged as a promising solution for the decoding of big data. ML imitates the human brain to process data, significantly improving accuracy and efficiency compared with traditional processing methods. In this review, we first introduce the commonly used ML algorithms and advanced mass spectrometry and spectroscopy techniques in the field of IVD, respectively. The ML algorithms are summarized as four aspects according to different learning tasks. Then, the combinations of ML with mass spectrometry, spectroscopy, and multi‐modal analysis for IVD are presented, and the roles of ML in these combinations are elucidated by some representative examples. This review aims to provide a systematic and comprehensive summary of the literature on ML‐assisted mass spectrometry or spectroscopy. We believe that it will facilitate researchers to select suitable ML algorithms for supplementing existing detection techniques or to develop the potential of coupling more detection techniques with ML, thus promoting the development of mass spectrometry and spectroscopy in IVD.

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Certification and Long-Term Stability Assessments of 5-Methyltetrahydrofolate in Spinach and Kimchi Cabbage Certified Reference Materials Using Tri-enzyme Method and Isotope Dilution Ultra-performance Liquid Chromatography/Tandem Mass Spectrometry

Hyung,

Lee

2024

Chromatographia

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Highly sensitive analytical method for the accurate determination of 5-methyltetrahydrofolic acid monoglutamate in various volumes of human plasma using isotope dilution ultra-high performance liquid chromatography-mass spectrometry

Cited by 4 publications

References 31 publications

Hollow multishelled heterostructures with enhanced performance for laser desorption/ionization mass spectrometry based metabolic diagnosis

Hollow multishelled heterostructures with enhanced performance for laser desorption/ionization mass spectrometry based metabolic diagnosis

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

Certification and Long-Term Stability Assessments of 5-Methyltetrahydrofolate in Spinach and Kimchi Cabbage Certified Reference Materials Using Tri-enzyme Method and Isotope Dilution Ultra-performance Liquid Chromatography/Tandem Mass Spectrometry

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