“…These groups can be incorporated in the MOFs during the synthesis (by using organic linker containing already those groups), or through post-synthetic modification (PSM) approaches by modifications on the linkers [ 32 ] or on open metal sites (OMS, known also as coordinatively unsaturated sites (CUS) or occasionally also as open coordination sites (OCS) [ 6 ]) [ 33 ]. For example, TMU-60 was synthesized using ligands with amino groups to form electron-rich pores capable of detecting different (electron-poor) metal ions such as Pb 2+ , Hg 2+ , Cu 2+ , Cd 2+ , Cr 2+ , Ni 2+ , and Cr 3 [ 34 ]; while Mg-MOF-74 films with open metal sites were post-synthetically modified with ethylenediamine and used as sensing materials for the detection of CO 2 and benzene [ 35 ]. More complex functional moieties can be also incorporated, such as biological recognition elements (i.e., antibodies, enzymes, DNA strands), forming the so-called biosensors that are capable fr endowing the MOFs with a higher level of selectivity or even specificity towards some analytes.…”