Highly Selective Vagotomy in the Rat: Effects on Bone and Mineral Metabolism

Rümenapf, G.; Schwille, P. O.; Wagner, Willis H.; Tiecks, Frank P.; Fries, Walter; Galewski, D

doi:10.3109/00365529409090469

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…16 In another study in the rat, it has been demonstrated that highly selective vagotomy, which normally blocks stomach acid production, does not interfere with body weight, food intake, intestinal resorption, mineral balance, and bone mineralization, while serum PTH levels and urinary hydroxyproline excretion increase. 17 Moreover, these observations argue against a role of gastric acidity in intestinal calcium resorption and are in favor of less efficient intestinal calcium resorption after vagotomy. In another rat study, it was elegantly shown that Gx evokes hyperphosphaturia and increases of cyclic AMP levels in the presence of persistent normal serum PTH levels.…”

Section: Estrogen-deprived Bone Loss Versus Gastrectomy-evoked Bone Lossmentioning

confidence: 98%

Mineral Metabolism and Bone Disease after Bariatric Surgery and Ways to Optimize Bone Health

Schweitzer

2007

OBES SURG

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There is no consensus on how to protect the skeleton with adequate supplements in patients who have undergone bariatric operations. The main problem in mineral metabolism is usually related to secondary hyperparathyroidism (2 degrees HPT), often caused by a lack of dietary calcium, magnesium or vitamin D, together with changes in intestinal fermentation, transit time, and resorption surfaces left behind after bariatric operations. After primarily restrictive bariatric surgery, adequate mineral metabolism depends mainly on the active metabolite of vitamin D, whereas after primarily malabsorptive surgery, it depends largely on passive resorption by means of the calcium sensitizing receptor (CaSR). Notably, CaSR-activated calcium transport is coupled to the presence of sufficient magnesium. The current review discusses clinically relevant mechanisms of mineral metabolism and provides recommendations for adequate calcium, magnesium, and vitamin D supplementation. Nevertheless, formal supplementation guidelines are needed in the near future.

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Section: Estrogen-deprived Bone Loss Versus Gastrectomy-evoked Bone Lossmentioning

confidence: 98%

Mineral Metabolism and Bone Disease after Bariatric Surgery and Ways to Optimize Bone Health

Schweitzer

2007

OBES SURG

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“…The findings of this experimental model are similar to those of senile osteoporosis. Common findings in total gastrectomized rats are decreases in both cortical and cancellous bone mass (15,18,34,39), anemia (29) and reduced intestinal calcium absorption (27). Furthermore, our preliminary experiment using this model exhibits hyperparathyroidism and an elevation of 1,25-dihydroxyvitamin D in blood.…”

Section: Fos and Bonementioning

confidence: 95%

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

Morohashi

2002

Bioscience Microflora

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Several studies have been carried out to establish the role of calcium and magnesium in bone. These minerals may play an important role in bone structure or strength. Fructooligosaccharides (FOS) are known to be stimulators of intestinal mineral absorption. In intact rats, bone volume and the mineral content (Ca, and Mg ) of the bone surface are greater in FOS-fed rats. Moreover, a significant relationship exists between the absorption of these minerals and their content in bone. Osteopenia is known to follow total gastrectomy in animals, leading to the severe concordant loss of both cortical and cancellous bone. These findings are similar to senile osteoporosis in humans. Dietary FOS completely prevents the gastrectomy-induced osteopenia in rats. If similar effects are found in humans, an increase in mineral deposition in bone during growth may contribute to the prevention of bone disease with age. Thus FOS might be a promising prebiotic for bone.

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“…(11) Common findings in GX rats include decreased bone mass, (12–14) anemia, (15) and decreased intestinal calcium (Ca) absorption. (16) …”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats

Kimira

Tajima

Ohta

et al. 2012

J. Clin. Biochem. Nutr.

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Fructooligosaccharides stimulate the growth of Bifidobacteria, which cleave isoflavone glycosides to yield corresponding aglycones, and convert metabolites by enhancing enterohepatic recirculation of isoflavones in rats. In the present study, we determined the synergistic effect of dietary isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats. Nine-week-old male Sprague-Dawley rats were gastrectomized (n = 20) or sham operated, (control, n = 5) and then randomly assigned to 5 diet groups: sham-a purified diet control, gastrectomized-control, gastrectomized-isoflavone (0.2% isoflavone glycosides), gastrectomized-fructooligosaccharides (7.5% fructooligosaccharides), and isoflavone and fructooligosaccharides (0.2% isoflavone glycosides + 7.5% fructooligosaccharides). After 6 weeks, the rats were killed and biological samples were collected. In gastrectomized rats, fructooligosaccharides prevented femoral bone fragility, but isoflavone without fructooligosaccharides did not inhibit postgastrectomy osteopenia. Isoflavone and fructooligosaccharides exhibited a synergistic in the distal metaphyseal trabecular bone, indicated by peripheral quantitative computed tomography. Moreover, fructooligosaccharides increased calcium absorption and equol production from daidzein in gastrectomized rats. These results indicate that isoflavone alone did not inhibit postgastrectomy osteopenia, but the combination of isoflavone and fructooligosaccharides improved the inhibition of trabecular bone loss by increasing calcium absorption and equol production through fructooligosaccharides supplementation.

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Highly Selective Vagotomy in the Rat: Effects on Bone and Mineral Metabolism

Cited by 15 publications

References 28 publications

Mineral Metabolism and Bone Disease after Bariatric Surgery and Ways to Optimize Bone Health

Mineral Metabolism and Bone Disease after Bariatric Surgery and Ways to Optimize Bone Health

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

Synergistic effect of isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats

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