Highly selective synthesis of tricyclic compounds from semithioglycoluril, formaldehyde and amines

Synthesis and Structure of 1-Substituted Semithioglycolurils

“…6,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Although a wide range of trisubstituted semithioglycolurils I and II have been reported, they are still actively investigated, as some of them have antifungal and cytotoxic activities. 12,13 Other compounds III-IX are represented by several examples and used as scaffolds in the synthesis of semithiobambusurils (III and VII), 11,27 in Claisen condensation matrices (IV), 10 and in the synthesis of tri-, tetra-, and polycyclic systems (V) [28][29][30][31] and iminoglycolurils (V, VII, VIII). 6 Methods for the preparation of a small number of compounds III-IX reported in the literature are underdeveloped.…”