Highly selective on-off fluorescence recognition of Fe3+ based on a coumarin derivative and its application in live-cell imaging

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

“…The presence of other ions did not interfere with the detection of iron (III) ions and the limit of detection was found to be 0.76 μM. Moreover, cell imaging and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay proved the potential utility of probe 192 as cell-permeable chemosensor of Fe 3+ in living cells [ 247 ].…”

Furo[3,2-c]coumarin-derived Fe3+ Selective Fluorescence Sensor: Synthesis, Fluorescence Study and Application to Water Analysis

“…This suggestion is supported by considering the paramagnetic nature of Fe 3+ with an unfilled d shell, this would take part in the energy and/or electron transfer processes leading to quenching of the fluorescence 80,81 . We suspect, when Fe 3+ binds with FH, the fluorescent opens a non-radiative deactivation channel induced by the unfilled d shell, resulting in fluorescence quenching due to electron transfer 82 . Thus, the mechanism of LMCT could happen promptly due to the strong paramagnetic quenching property of Fe 3+ , leading to a severe fluorescence quenching effect (i.e., turn-off) to coordinate between FH and Fe 3+ .…”

Idiosyncatic recognition of Zn2+ and CN− using pyrazolyl-hydroxy-coumarin scaffold and live cell imaging: depiction of luminescent Zn(ii)-metallocryptand

“…49 The use of coumarin derivatives are potentially effective for sensing as well as biological applications. 50,51 In this account, we design and structurally characterize coumarin-based Schiff base, ( Z )-7-hydroxy-4-methyl-8-(((5-phenyl-1 H -pyrazol-3-yl)imino)methyl)-2 H -chromen-2-one (H 2 L), which serves as a chemosensor for the sensing of Zn 2+ ( λ em = 499 nm, LOD, 34.76 nM) and CN − ( λ em = 447 nm LOD, 19.91 nM) with distinctive fluorescence responses at two emissive states in acetonitrile medium. The interaction of Zn 2+ and H 2 L has isolated a metallocryptand hexanuclear complex, [Zn 6 L 6 ].…”