Highly selective nicotinohydrazide based ‘turn-on’ chemosensor for the detection of bioactive zinc(II): Its biocompitability and bioimaging application in cancer cells

Quantum chemical elucidation of the turn-on luminescence mechanism in two new Schiff bases as selective chemosensors of Zn2+: synthesis, theory and bioimaging applications

“…Results showed that the uorescence intensity exhibited a maximum when the molar fraction of HL was $0.5, demonstrating a 1 : 1 binding stoichiometry between the compounds A and B, and Zn 2+ . 40 3.3. Computational studies 3.3.1.…”

“…Zinc is the most abundant trace element essential in cellular functions of the body, and plays an important role in fundamental biological processes, such as DNA synthesis, RNA transcription, regulation of metalloenzymes, neurophysiology, and apoptosis. 1,2 According to medical research, the imbalance of zinc in human bodies can result in several serious diseases, such as diabetes, neurodegenerative disorders, and certain types of cancer. [3][4][5][6] Since biological systems require an adequate concentration of zinc for their optimal functioning, 7-9 different methods for this detection have been proposed.…”

Aggregation‐Induced Emission‐Based Sensing Platform for Selective Detection of Zn2+: Experimental and Theoretical Investigations

“…Various analyte-specific probes for detection of Zn 2 + , Cu 2 + , Hg 2 + and Al 3 + based on such systems have been reported by us. [15] In Table S1, selected aspects of recently published α-hydroxy aromatic Schiff base Zn 2 + sensors [14d,15g,h, [21][22][23][24][25][26][27][28] are compiled, clearly showing that even a slight modification in the chemical structure of a probe may lead to its different photophysical and chemical properties affecting its functionality and applications, such as the limit of detection, selectivity, and also AIEE features. Moreover, depending on molecular structure, a different signaling mechanism may take place.…”

Thiazole‐based Orange‐emitting Excited‐State Intramolecular Proton Transfer Chemosensors for Selective and Ratiometric Sensing of Zn2+ Ions

“…Investigation of highly sensitive and selective fluorescent materials for transition metal ions has attracted significant interest because of their important roles in biological and environmental importances . Because the second most plentiful transition metal ion in human body, Zn 2+ plays various critical roles in biological functions including neuronal signal transmission, enzymatic regulations, influencing DNA synthesis, and numerous cellular functions . In this respect, sensitive and noninvasive technique to detect free zinc ions, which are spectroscopically silent due to its 3d 10 electron configurations, is one of the important research areas .…”