Highly selective and sensitive fluorescent probe possessing AIEE and ICT properties for rapid detection of Pb<sup>2+</sup> in aqueous medium and its applications in living cells

Xue, Shuai; Xie, Zhenzhen; Chu, Yicheng; Shi, Wei; Liu, Yucheng; Zhao, Yun‐Hui

doi:10.1002/bio.4151

Cited by 9 publications

(3 citation statements)

References 49 publications

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“…DBTBH is a Schiff base fluorescent probe amended with a benzenesulfonylhydrazone derivative [79]. The probe exhibits rapid, efficient, and sensitive response to Pb 2+ in THF/Tris-HCl buffer (10 mM, 1 mM KI, pH = 7.4) (1:9, v/v), with a detection limit of 4.49 × 10 −8 M. The recognition process exhibits excellent optical properties of aggregation-induced emission enhancement (AIEE) and intramolecular charge transfer (ICT).…”

Section: Fluorescent Probes To Detect Pb 2+mentioning

confidence: 99%

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

et al. 2023

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One of the main challenges faced in food safety is the accumulation of toxic heavy metals from environmental sources, which can sequentially endanger human health when they are consumed. It is invaluable to establish a practical assay for the determination of heavy metals for food safety. Among the current detection methods, technology based on fluorescent probes, with the advantages of sensitivity, convenience, accuracy, cost, and reliability, has recently shown pluralistic applications in the food industry, which is significant to ensure food safety. Hence, this review systematically presents the recent progress on novel fluorescent probes in determining heavy metals for food safety over the past five years, according to fluorophores and newly emerging sensing cores, which could contribute to broadening the prospects of fluorescent materials and establishing more practical assays for heavy metal determinations.

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Section: Fluorescent Probes To Detect Pb 2+mentioning

confidence: 99%

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

et al. 2023

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“…It also possessed a larger Stokes shift and a pronounced UVvis absorption redshift, suggesting the great potential of Hg 2+ detection in living cells (Pei et al, 2023). Moreover, (E)-N 0 -{[2-(4′-(diphenylamino)-(1,1′-biphenyl)-4-yl)-2H-1,2,3-triazol-4-yl] methylene} (DBTBH) was synthesized for Pb 2+ detection with a limit Frontiers in Chemistry frontiersin.org concentration of 4.49 × 10 −8 M in HeLa cells, showing a promising platform for biological applications (Xue et al, 2021). In addition, a dual fluorescence probe 7-hydroxy-8-{ [(2-(hydroxymethyl) quinolin-8-yl)imino]methyl}-coumarin (XL), which consists of formylcoumarin and aminoquinoline moieties, was obtained for Zn 2+ and Al 3+ ion detection in PC12 cells, with detection limits of 3.75 × 10 −8 and 1.14 × 10 −8 M, respectively (Fu et al, 2020).…”

Section: Metal Ion Detectionmentioning

confidence: 99%

ICT-based fluorescent probes for intracellular pH and biological species detection

Wu,

Ge,

Zhang

et al. 2023

Front. Chem.

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Fluorescent probes, typically based on the intramolecular charge transfer (ICT) mechanism, have received considerable research attention in cell detection due to their non-invasiveness, fast response, easy regulation, high sensitivity, and low damage tolerance for in vivo bio-samples. Generally, intracellular pH and biological species such as various gases, metal ions, and anions constitute the foundation of cells and participate in the basic physiological processes, whose abnormal level can lead to poisoning, cardiovascular disease, and cancer in living organisms. Therefore, monitoring of their quantity plays an essential role in understanding the status of organisms and preventing, diagnosing, and treating diseases. In the last decades, remarkable progress has been made in developing ICT probes for the detection of biological elements. In this review, we highlight the recent ICT probes focusing primarily on the detection of intracellular pH, various gases (H2S, CO, H2O2, and NO), metal ions (Cu2+, Hg2+, Pb2+, Zn2+, and Al3+), and anions (ClO−, CN−, SO32−, and F−). In addition, we discuss the issues and limitations of ICT-based fluorescent probes for in vivo detection and explore the clinical translational potential and challenges of these materials, providing valuable guidance and insights for the design of fluorescent materials.

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“…So far, many probes for detecting Zn 2+ and Pb 2+ have been reported. Nevertheless, their fluorescent signals are mainly located at blue and green light regions [27][28][29][30][31][32][33][34][35][36][37][38]. Comparatively speaking, the near-infrared (NIR) fluorescent probes can effectively avoid the interference of sample background, and have better application potential.…”

Section: Introductionmentioning

confidence: 99%

Two near-infrared fluorescent probes based on dicyanoisfluorone for rapid monitoring of Zn²⁺ and Pb²⁺

Li¹,

Zhou²,

Yang³

et al. 2022

Methods Appl. Fluoresc.

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Zinc (Zn2+) and lead (Pb2+) ions in the environment have important effects on human health and environmental safety. Therefore, it is of great significance to realize convenient and reliable detection of these two metal ions. In this study, two near-infrared fluorescent probes for the fast detection of Zn2+ and Pb2+ were synthesized by a simple Schiff base reaction between the dicyanoisophorone skeleton and carbohydrazide derivatives. Among them, the probe with the thiophene-2-carbohydrazide group showed a selective fluorescence response to Zn2+ and Pb2+ with a maximum emission wavelength of 670 nm. And the detection limits of the probe for Zn2+ and Pb2+ were 1.59 nM and 1.65 nM, respectively. In contrast the probe modified by the furan-2-carbohydrazide group achieved quantitative detection of Zn2+, with a detection limit of 2.7 nM. These results were attributed to the fact that the probes bind to Zn2+ and Pb2+ in stoichiometric ratios of 1:1, blocking the intramolecular PET effect. Furthermore, these two probes can be recycled through the action of EDTA and have been successfully used to detect Zn2+ and Pb2+ in real water samples.

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Highly selective and sensitive fluorescent probe possessing AIEE and ICT properties for rapid detection of Pb²⁺ in aqueous medium and its applications in living cells

Cited by 9 publications

References 49 publications

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

ICT-based fluorescent probes for intracellular pH and biological species detection

Two near-infrared fluorescent probes based on dicyanoisfluorone for rapid monitoring of Zn²⁺ and Pb²⁺

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Highly selective and sensitive fluorescent probe possessing AIEE and ICT properties for rapid detection of Pb2+ in aqueous medium and its applications in living cells

Cited by 9 publications

References 49 publications

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

Recent Progress on Fluorescent Probes in Heavy Metal Determinations for Food Safety: A Review

ICT-based fluorescent probes for intracellular pH and biological species detection

Two near-infrared fluorescent probes based on dicyanoisfluorone for rapid monitoring of Zn2+ and Pb2+

Contact Info

Product

Resources

About

Highly selective and sensitive fluorescent probe possessing AIEE and ICT properties for rapid detection of Pb²⁺ in aqueous medium and its applications in living cells

Two near-infrared fluorescent probes based on dicyanoisfluorone for rapid monitoring of Zn²⁺ and Pb²⁺