Highly selective and sensitive fluorescence probe based on thymine-modified carbon dots for Hg<sup>2+</sup> and <scp>l</scp>-cysteine detection

Xu, Hui; Huang, Shanshan; Liao, Caiyun; Yang, Li; Zheng, Baozhan; Du, Juan; Xiao, Dan

doi:10.1039/c5ra18432k

Cited by 25 publications

(10 citation statements)

References 52 publications

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“…Different strategies have been followed to incorporate the heteroatoms to the CDs in a single step including hydrothermal synthesis, pyrolysis method and microwave synthesis . These heteroatom‐doped CDs are potentially applied in many areas like bioimaging, sensing of metal ions and molecules as well as catalysis . Recently, iodide has been successfully detected in low levels using heteroatom carbon quantum dots by following the turn on–off sensing method .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

et al. 2017

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A facile and novel strategy to synthesize nitrogen- and phosphorous-doped carbon dots (NPCDs) by single step pyrolysis method is described here. Citric acid is used as carbon source and di-ammonium hydrogen phosphate is used as both nitrogen and phosphorous sources, respectively. Through the extensive study on optical properties, morphology and chemical structures of the synthesized NPCDs, it is found that as-synthesized NPCDs exhibited good excitation-dependent luminescence property, spherical morphology and high stability. The obtained NPCDs are stable in aqueous medium and possess a quantum yield of 10.58%. In this work, a new assay method is developed to detect iodide ions using the synthesized NPCDs. Here, the inner filter effect is applied to detect the iodide ion and exhibited a wide linear response concentration range (10-60 μM) with a limit of detection (LOD) of 0.32 μM. Furthermore, the synthesized NPCDs are used for the selective detection of iron(III) (Fe ) ions and cell imaging. Fe ions sensing assay shows a detection range from 0.2 to 30 μM with a LOD of 72 nM. As an efficient photoluminescence sensor, the developed NPCDs have an excellent biocompatibility and low cytotoxicity, allowing Fe ion detection in HeLa cells.

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Section: Introductionmentioning

confidence: 99%

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

et al. 2017

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“…Such an effect is consistent with those reported for the “off–on” fluorescence detection of amino acids by CQD–Hg 2+ systems. 7 , 46 …”

Section: Resultsmentioning

confidence: 99%

Carbon Quantum Dot-Incorporated Chitosan Hydrogel for Selective Sensing of Hg²⁺ Ions: Synthesis, Characterization, and Density Functional Theory Calculation

et al. 2021

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A carbon quantum dot-based chitosan hydrogel was prepared in this work as a fluorescence sensor for the selective sensing of Hg 2+ ions. Among the eight tested metal ions, the prepared hydrogel exhibited remarkable sensing selectivity and sensitivity toward Hg 2+ . The results demonstrated that a prominent fluorescence quenching at 450 nm was observed in the presence of Hg 2+ with a linear response range of 0–100.0 nM and an estimated limit of detection of 9.07 nM. The as-prepared hydrogel demonstrates pH-dependent fluorescence intensity and sensitivity. The highest fluorescence intensity and sensitivity were obtained under pH 5.0. The excellent sensing selectivity could be attributed to a strong interaction between the hydrogel film and Hg 2+ ions to form complexes, which provokes an effective electron transfer for fluorescence quenching. Results from density functional theory (DFT) calculation confirm that the interaction energies (ΔIE) of the hydrogel with three toxic metal ions (Hg 2+ , Cd 2+ , and Pb 2+ ) are in the following order: Hg 2+ > Cd 2+ > Pb 2+ .

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“…The content of N was higher than that of carbon dots in the general literature [42,43,44], which corresponded to the self–surface passivation of carbon dots. As shown in Figure 2b, the C 1s spectrum displayed four main peaks at 284.3 eV, 285.6 eV, 287.15 eV, 288.3 eV, which were associated with C–C, C–N [45], C=O/C=N, and O=C–N [46], respectively. As exhibited in Figure 2c, for the N 1s spectrum, there were three binding energy peaks, at 399.2, 400.55 and 401.65 eV, that probably resulted from N–H, pyrrolic N and N–O.…”

Section: Resultsmentioning

confidence: 99%

Sensitively and Selectively Detect Biothiols by Using Fluorescence Method and Resonance Light Scattering Technique Simultaneously

et al. 2019

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In this paper, we designed a new quantitative and qualitive detection method for biothiols by using fluorescence method and resonance light scattering (RLS) technique. Nitrogen doped carbon quantum dots (C/N-dots) were obtained from tartaric acid and ethylenediamine by hydrothermal method, and then their morphology and optical properties were characterized by different techniques. A detection system consisting of C/N-dots and Ag+ complex was established. In this system, C/N-dots possessed the photoluminescent property and the Ag+ complex owned the RLS property, so, by combining the two luminescent properties to achieve complementary advantages, we could detect biothiols and solve the problem of distinguishing between Cys and GSH. Additionally, we optimized detecting conditions and investigated the detection mechanism of fluorescence quenching and RLS detecting. Results showed that the analytical response of fluorescence was linear in the range 0–140 μM and the detection limit (LOD) was calculated to be 6.6 μM for Cys, and the addition of GSH had no effect on fluorescence. RLS response ranges were 0–167 μM for Cys and 0–200 μM for GSH, with LOD down to 64 nM and 74 nM, respectively. Furthermore, the probe was successfully used for detecting Cys in fetal bovine serum (FBS) samples by fluorescence method, and also, by RLS technique, the content of GSH in FBS samples was detected.

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Highly selective and sensitive fluorescence probe based on thymine-modified carbon dots for Hg²⁺ and l-cysteine detection

Abstract: The as-prepared thymine-modified carbon dots were applied to as a sensor for detecting Hg2+ and l-cysteine with high sensitivity and selectivity.

Cited by 25 publications

References 52 publications

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

Carbon Quantum Dot-Incorporated Chitosan Hydrogel for Selective Sensing of Hg²⁺ Ions: Synthesis, Characterization, and Density Functional Theory Calculation

Sensitively and Selectively Detect Biothiols by Using Fluorescence Method and Resonance Light Scattering Technique Simultaneously

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Highly selective and sensitive fluorescence probe based on thymine-modified carbon dots for Hg2+ and l-cysteine detection

Abstract: The as-prepared thymine-modified carbon dots were applied to as a sensor for detecting Hg2+ and l-cysteine with high sensitivity and selectivity.

Cited by 25 publications

References 52 publications

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

Fabrication of nitrogen‐ and phosphorous‐doped carbon dots by the pyrolysis method for iodide and iron(III) sensing

Carbon Quantum Dot-Incorporated Chitosan Hydrogel for Selective Sensing of Hg2+ Ions: Synthesis, Characterization, and Density Functional Theory Calculation

Sensitively and Selectively Detect Biothiols by Using Fluorescence Method and Resonance Light Scattering Technique Simultaneously

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Product

Resources

About

Highly selective and sensitive fluorescence probe based on thymine-modified carbon dots for Hg²⁺ and l-cysteine detection

Carbon Quantum Dot-Incorporated Chitosan Hydrogel for Selective Sensing of Hg²⁺ Ions: Synthesis, Characterization, and Density Functional Theory Calculation