Highly Selective and Sensitive Detection of Dopamine in the Presence of Excessive Ascorbic Acid Using Electrodes Modified with C₆₀‐Functionalized Multiwalled Carbon Nanotube Films

Abstract

Electrochemical detection of dopamine (DA) in the presence of a large excess of ascorbic acid (AA) was investigated with a novel all-carbon nanocomposite film of C 60 -MWCNTs (C 60 -functionalized multi-walled carbon nanotubes) using a bare MWCNTs film as control. Although both films can selectively detect DA from AA by separating their oxidation potentials, the C 60 -MWCNTs film shows special selectivity and good sensitivity for detecting DA. On one hand, the C 60 -MWCNTs composite film shows a higher activity for DA oxidation with enhanced peak current. On the other hand, the C 60 -MWCNTs composite film effectively suppresses the oxidation of AA. Remarkably, it is found that the oxidation current of DA is over 2 times higher than that of AA even when the concentration of AA is about 3 to 4 orders of magnitude higher than that of DA. This offers a tremendous advantage for the simple and clean detection of DA free of the interfering AA signal in a real assay. Cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectrometry are used to characterize the C 60 -MWCNTs composite film. These novel properties are interpreted to arise from the facile electron transfer between C 60 and MWCNTs in the C 60 -MWCNTs nanocomposite film.

Electrochemical Determination of Dopamine Based on Carbon Nanotube-Sol-Gel Titania-Nafion Composite Film Modified Electrode

“…As summarized in Table 1, the present DA sensor based on the CNT-titania-Nafion/GC electrode displayed a relatively low detection limit even without the additional loading of noble metal NPs such as Pt, Au and Pd [11][12][13][14] or a complicated CNT modification step. [18][19][20] However, the present sensor showed a relatively wide linear dynamic range from 0.5 μM to 500 μM. Moreover, the present DA sensor based on the CNT-titania-Nafion/GC electrode exhibited relatively fast response time less than about 2.0 s, which is much faster than those at the CNT-Nafion composite film (4.6 s) and titaniaNafion composite film (2.4 s) as shown in the current-time response profile (Figure 5, inset).…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] These include pretreatment and modification of electrode surface with various materials such as self-assembled monolayers, 4,5 permselective film coatings such as Nafion 6 and electropolymerized polymer, 7 zeolite, 2 cyclodextrins, 8 and DNA. 9 Because of the excellent electrocatalytic activity of noble metal nanoparticles (NPs), [11][12][13][14] carbon based nano-materials such as nanofiber, 15 graphene, 17 and nanotube, 10,[18][19][20] the DA sensors based on these nano-materials exhibited good sensitivity and stability. Despite of these great advantages of those carbonbased nano-materials, the insolubility of them, especially carbon nanotube (CNT), in most solvents is one of the most difficult obstacles for their wide application in electrochemical sensors.…”

Recent Advances on Multi-Dimensional Nanocarbons for Superapacitors: A Review

“…A fullerene-C 60 -modified edge plane pyrolytic graphite electrode was demonstrated to electrochemically investigate prednisone [37]. Dopamine sensors were fabricated using C 60 -functionalized MWCNT films [38]. The C 60 -MWCNTs film showed special selectivity and sensitivity for detection of dopamine than those of a bare MWCNT film.…”

Enhanced Electrochemical Response of Diclofenac at a Fullerene–Carbon Nanofiber Paste Electrode

“…Also, they are cheaper in comparison with carbon nanotubes due to the synthesis method [20]. The effect of C 60 on improving electroanalytical performance in the detection of vinclozolin [21], dopamine [22], and hemoglobin [23] has been reported using carbon nanotube-based supportive materials. In our work, the effect of fullerene (C 60 ) on DCF detection using a CNF support is studied.…”