Highly selective A₁‐adenosine‐agonist (2‐chloro‐N⁶‐cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats

Abstract

Our data show that reduction of flap necrosis can be achieved both with and without ischemic periods by intravenous administration of CCPA.

Histological effect on the adipocutaneous flap in rats after preconditioning with 2‐chloro‐N6‐cyclopentyladenosine

“…In 2005, Hu et al demonstrated similar effects already in rat hearts by a selective blocking of adenosine receptors in tissue and on neutrophils by the administration of 8‐phenyl‐theophyllin. The interaction of fewer cells and the inhibition of neutrophil activity in adenosine groups led to a significant reduction of flap necrosis with improved survival of the tissue, as we showed in our previous study . Our data demonstrate that the adenosine receptor system within the neutrophils is most likely of more importance in the context of I/R injury than expected, but it remains unclear why this happens specifically in healthy subcutis (Table ).…”

“…The interaction of fewer cells and the inhibition of neutrophil activity in adenosine groups led to a significant reduction of flap necrosis with improved survival of the tissue, as we showed in our previous study. 14 Our data demonstrate that the adenosine receptor system within the neutrophils is most likely of more importance in the context of I/R injury than expected, but it remains unclear why this happens specifically in healthy subcutis (Table 3). On the other hand, a significant reduction in the number of plasma cells can be verified, in addition to the changes of the amount of neutrophils in flaps adjacent to localization A.…”

“…20 mm, AESCULAP AG, Tuttlingen, Germany) on the pedicle depending on the experimental group. In the CCPA‐groups, a single shot infusion with a dosage of 25 ng/g CCPA per animal was applied before raising the flap …”

“…E-mail: dacho@web.de significant reduction of tissue necrosis in the adipocutaneous flap of rats with and without ischemic preconditioning. 14 Besides less necrosis and improved flap survival, activation of inflammatory cells and stimulation of mediators are in focus of repair, demarcation, and scarring of infarcted tissue in I/R injury.…”

An Adenosine A₁ Agonist 2-Chloro-N6 Cyclopentyladenosine Inhibits the Angiotensin II-Induced Cardiomyocyte Hypertrophy through the Calcineurin Pathway

“…Adenosine can inhibit norepinephrine release and attenuate the activation of the renin-angiotensin system, meaning it can prohibit cardiomyocyte hypertrophy. 2-Chloro-N6 cyclopentyladenosine (CCPA) is warranted as an adenosine A 1 receptor agonist [19,20]. We speculate that CCPA may ameliorate cardiac hypertrophy.…”