Highly regioselective homogeneous isomerization-hydroformylation of 2-butene with water- and air-stable phosphoramidite bidentate ligand

Coordination assembly enables highly selective catalytic hydroaminomethylation of olefins

“…S65 †) was observed in the 1 H NMR spectra of the mixture, implying NHC-Rh-H was the active species, which was also consistent with previous studies. [61][62][63] Because the solid 6b was recovered after filtration and washing with water, methanol and diethyl ether subsequently, no Rh-H could be monitored after the recycling tests.…”

Modular Synthesis of Phosphite and Phosphoramidite Ligands for Rh‐Catalyzed Hydroformylation

“…Up to 98 % linear selectivity was obtained in asymmetric hydroformylation of vinyl ethers in 7 examples (Scheme 31a). Zheng [75] et al used this ligand in the regioselective isomerization-hydroformylation of 2-butene, and the ligand's strong πacceptor ability was a key factor in the rapid isomerization of this reaction. Therefore, higher n-valeraldehyde product (up to 99 % linear selectivity) could be obtained (Scheme 31b).…”

A diphosphoramidite ligand for hydroformylation of various olefins

“…For example, the privileged atropisomeric 1,1′-bi-2-naphthol (BINOL) backbone based pyrrolylphosphoramidite ligand pyBN afforded better catalytic performance than pyBP. 9 Encouraged by these results, we were interested in the development of a new atropisomeric diphosphorus ligand, the axial rotation of which could further be restricted by incorporating sterically more hindered substituents in the biphenol backbone. With this aim, we designed a pyrrolylphosphoramidite ligand, namely pyTFBP, the backbone of which was derived from BIPOL by fusion with two tetrahydrobenzofuran (TF) rings at the 5,6 and 5′,6′ positions, respectively (Scheme 1(c)).…”