Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy

Gao, Xiaoting; Jiang, Shanshan; Li, Chunying; Chen, Yunzhi; Zhang, Yifan; Huang, Peng; Lin, Jing

doi:10.1016/j.biomaterials.2020.120454

Cited by 41 publications

(29 citation statements)

References 51 publications

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“…After treatment with GGT, the size of NRh-NH 2 -NPs was decreased to 20-30 nm ( Figure S12 ). The hydrodynamic size measured by DLS was decreased from 90 nm ( Figure 1 D ) to 70 nm ( Figure S13 ) 18 . The zeta potential was also changed from -0.3 mV ( Figure 1 D ) to 6.0 mV ( Figure S13 ).…”

Section: Resultsmentioning

confidence: 98%

“…However, after enzyme incubation, the speed of the temperature rise and the final temperature reached were proportional to the concentration of NRh-G-NPs under the same laser irradiation condition ( Figure 4 C ). Infrared thermographies of NRh-G-NPs (34.6 μg/mL) in Figures 4 B and 4C, which were exposed to 730 nm laser for 5 min are displayed in Figure 4 D 15 - 18 . Moreover, the excellent photothermal stability of the product NRh-NH 2 -NPs was also confirmed ( Figure S26 ).…”

Section: Resultsmentioning

confidence: 99%

“…The ideal photothermal conversion agents should be non-toxic, with high tumor-targeting and efficient photothermal conversion capabilities 11 - 14 . Furthermore, the self-imaging capability is preferred to identify the accumulation of photothermal agents to better guide the laser operation timing and dosage 15 - 18 .…”

Section: Introductionmentioning

confidence: 99%

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γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

Zhou¹,

Yang²,

Zhao³

et al. 2021

Theranostics

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Rationale: Precise treatment of tumors is attracting increasing attention. Molecular probes simultaneously demonstrating the diagnostic signal and pharmacological effect in response to tumor microenvironment are highly desired. γ-glutamyl transpeptidase (GGT) is a biomarker with significantly up-regulated expression in the tumor area. We developed a GGT responsive near-infrared (NIR) nanoassembly for tumor-specific fluorescence imaging-guided photothermal therapy. Methods: The GGT responsive NIR probe was constructed by conjugating GGT-specific substrate γ-glutamic acid (γ-Glu) with cyanine fluorophore (NRh-NH 2 ) via amide reaction. The resulting NRh-G spontaneously assembled into nanoparticles (NRh-G-NPs) around 50 nm. The NPs were characterized and the properties evaluated in the presence or absence of GGT. Subsequently, we studied fluorescence imaging and photothermal therapy of NRh-G-NPs in vitro and in vivo . Results: NRh-G-NPs, upon specific reaction with GGT, turned into NRh-NH 2 -NPs, showing a ~180-fold fluorescence enhancement and excellent photothermal effect recovery. NRh-G-NPs could selectively light up U87MG tumor cells while their fluorescence was weak in L02 human normal liver cells. The NPs also showed excellent tumor cell ablation upon laser irradiation. After intravenous injection into tumor-bearing mice, NRh-G-NPs could arrive in the tumor area and specifically light up the tumor. Following laser irradiation, the tumor could be completely erased with no tumor reoccurrence for up to 40 days. Conclusions: NRh-G-NPs were specifically responsive to GGT overexpressed in U87MG tumor cells and selectively lit up the tumor for imaging-guided therapy. Besides, the recovery of photothermal property in the tumor area could improve cancer therapy precision and decreased side effects in normal tissues.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

Zhou¹,

Yang²,

Zhao³

et al. 2021

Theranostics

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“…living system. [51][52][53][54][55] In our previous work, we reported that the J-aggregation of BODIPY dyes yielded a pure organic PTA with striking performance including red-shifted absorbance into the NIR region, high PCE, and significant resistance against photobleaching. [56][57][58] We thus employed BODIPY J-aggregates as the photothermal component of the nanosystem (Figure 2a).…”

Section: Stable J-aggregation Of Bodipy As the Ptamentioning

confidence: 99%

A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy

Yang

Luo

et al. 2021

Small

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“…Biomedical luminescence imaging has broad applications in life science due to its ability to achieve real-time investigation of physiological and pathological processes with fast feedback, high sensitivity, high spatiotemporal resolution [1][2][3][4][5][6]. In order to act as luminescence contrast agents, a lot of luminescence probes, including organic dyes [7][8][9][10][11][12][13][14][15][16][17][18][19][20], quantum dots (QDs) [21][22][23][24][25], rare-earth doped nanoparticles (RENPs) [26][27][28][29][30][31], single-walled carbon nanotubes (SWCNTs) [32,33], metal-ligand complexes [34,35] and semiconducting polymer nanomaterials (SPN) [36,37] have been explored. Over the past few years, significant efforts have been made to create luminescence contrast agents that operate in the near-infrared window (700-1700 nm), which offers the enhanced tissue penetration over 5 mm [38][39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Near-infrared probes for luminescence lifetime imaging

Li¹,

Lin²,

Huang³

et al. 2022

Nanotheranostics

Self Cite

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Biomedical luminescence imaging in the near-infrared (NIR, 700-1700 nm) region has shown great potential in visualizing biological processes and pathological conditions at cellular and animal levels, owing to the reduced tissue absorption and scattering compared to light in the visible (400-700 nm) region. To overcome the background interference and signal attenuation during intensity-based luminescence imaging, lifetime imaging has demonstrated a reliable imaging modality complementary to intensity measurement. Several selective or environment-responsive probes have been successfully developed for luminescence lifetime imaging and multiplex detection. This review summarizes recent advances in the application of luminescence lifetime imaging at cellular and animal levels in NIR-I and NIR-II regions. Finally, the challenges and further directions of luminescence lifetime imaging are also discussed.

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Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy

Cited by 41 publications

References 51 publications

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy

A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy

Near-infrared probes for luminescence lifetime imaging

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