Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

Marinova‐Petkova, Atanaska; Franks, John; Tenzin, Sangay; Dahal, Narapati; Dukpa, Kinzang; Dorjee, Jambay; Feeroz, Mohammed Mostafa; Rehg, Jerold E.; Barman, Subrata; Krauss, Scott; McKenzie, Pamela; Webby, Richard J.; Webster, Robert G.

doi:10.3201/eid2212.160611

Cited by 16 publications

(11 citation statements)

References 11 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, the global concern about H9N2 viruses is associated with their ability to donate their genes to other AIV giving rise to high and low pathogenic IAVs that could cross species barriers and infect humans ( Figure 6 ). In addition to the zoonotic H5N6, H7N9 and H10N8 AIV, the H9N2 viruses also donated their internal genes to other IAVs, such as avian H5N1 [ 140 , 141 ], H5N2 [ 136 , 141 ], H1N2, H3N2, H6N2 [ 141 ], and H6N6 [ 142 ].…”

Section: Evolution and Epidemiology Of Iavmentioning

confidence: 99%

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Mostafa

Mettenleiter

et al. 2018

Viruses

210

221

View full text Add to dashboard Cite

Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments during co-infection of the host cell with different IAV strains, resulting in a high genetic diversity. Variants of circulating or newly emerging IAVs continue to trigger global health threats annually for both humans and animals. Here, we provide an introduction on IAVs, highlighting the mechanisms of viral evolution, the host spectrum, and the animal/human interface. Pathogenicity determinants of IAVs in mammals, with special emphasis on newly emerging IAVs with pandemic potential, are discussed. Finally, an overview is provided on various approaches for the prevention of human IAV infections.

show abstract

Section: Evolution and Epidemiology Of Iavmentioning

confidence: 99%

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Mostafa

Mettenleiter

et al. 2018

Viruses

210

221

View full text Add to dashboard Cite

show abstract

“…Influenza A virus (IAV) is highly infectious, and causes significant morbidity and mortality worldwide ( Ly et al, 2016 ; Marinova-Petkova et al, 2016 ; Thomas et al, 2017 ). Highly pathogenic avian influenza virus (H5N1-HPAIV) has been categorized as a List A disease by the International Office of Epizootics (OIE).…”

Section: Introductionmentioning

confidence: 99%

Defective Viral Particles Produced in Mast Cells Can Effectively Fight Against Lethal Influenza A Virus

Huo

Cheng

Xiao³

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

Mast cells play an important role in the pathogenesis of highly pathogenic H5N1 avian influenza virus (H5N1-HPAIV) infection. Defective viral particles (DPs) can interfere with the replication of infectious viruses and stimulate the innate immune response of host cells. However, DPs arising from mast cells during HPAIV replication and their potent antiviral actions has not been reported. Here, we showed that the human mastocytoma cell line, HMC-1, allowed for the productive replication of the H5N1-HPAIV. Compared with alveolar cell line A549, DPs were propagated preferentially and abundantly in mast cells following IAV infection, which can be attributed to the wide existence of Argonaute 2 (AGO2) in HMC-1 cells. In addition, DPs generated in H5N1-infected cells could provide great therapeutic protection on mice to fight against various influenza A viruses, which included not only homologous H5N1-HPAIV, but also heterologous H1N1, H3N2, H7N2, and H9N2. Importantly, DPs generated in H5N1-infected HMC-1 cells could diminish viral virulence in vivo and in vitro by triggering a robust antiviral response through type II interferon signaling pathways. This study is the first to illustrate the arising of DPs in H5N1-HPAIV infected mast cells and explore their favorable ability to protect mice from influenza A viruses infection, which provides a novel insight and valuable information for the progress of new strategies to fight influenza A viruses infection, especially highly pathogenic avian influenza virus infection by focusing on the DPs generated in mast cells.

show abstract

“…The most commonly detected clade in this region was 2.2. Clade 2.3.2.1a was also common and was identified in India, Bangladesh, Nepal and Bhutan [18][19][20] [18,24]. The co-detection of genetically related avian influenza viruses in human and poultry during the same period suggested that viruses were transmitted from poultry to human in Bangladesh Pakistan and Nepal.…”

Section: Discussionmentioning

confidence: 92%

“…H5N1 viral clades reported in poultry in South Asian countries, January 2003 to December 2018[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

mentioning

confidence: 99%

The Pattern of Highly Pathogenic Avian Influenza H5N1 Outbreaks in South Asia

et al. 2019

View full text Add to dashboard Cite

Highly pathogenic avian influenza (HPAI) H5N1 has caused severe illnesses in poultry and in humans. More than 15,000 outbreaks in domestic birds from 2005 to 2018 and 861 human cases from 2003 to 2019 were reported across the world to OIE (Office International des Epizooties) and WHO (World Health Organization), respectively. We reviewed and summarized the spatial and temporal distribution of HPAI outbreaks in South Asia. During January 2006 to June 2019, a total of 1063 H5N1 outbreaks in birds and 12 human cases for H5N1 infection were reported to OIE and WHO, respectively. H5N1 outbreaks were detected more in the winter season than the summer season (RR 5.11, 95% CI: 4.28-6.1). Commercial poultry were three times more likely to be infected with H5N1 than backyard poultry (RR 3.47, 95% CI: 2.99-4.01). The highest number of H5N1 outbreaks was reported in 2008, and the smallest numbers were reported in 2014 and 2015. Multiple subtypes of avian influenza viruses and multiple clades of H5N1 virus were detected. Early detection and reporting of HPAI viruses are needed to control and eliminate HPAI in South Asia.

show abstract

Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

Cited by 16 publications

References 11 publications

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Defective Viral Particles Produced in Mast Cells Can Effectively Fight Against Lethal Influenza A Virus

The Pattern of Highly Pathogenic Avian Influenza H5N1 Outbreaks in South Asia

Contact Info

Product

Resources

About