Highly pathogenic influenza virus H5N1 found in Western Siberia is genetically related to viruses that circulated in Southeast Asia in 2003–2005

Онищенко, Г. Г.; Shestopalov, А. М.; Va, Ternovoĭ; Evseenko, V. A.; Durymanov, A. G.; Rassadkin, Yu. N.; Razumova, Yu. V.; Zaykovskaya, А. V.; Zolotykh, S. I.; Нетесов, С. В.; Sandakhchiev, L. S.

doi:10.1134/s0012496606010170

Cited by 6 publications

(3 citation statements)

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“…Previously, a phylogenetic relationship was established between low pathogenic strains of influenza A virus isolated from ducks during migration in western Siberia and strains circulating in different parts of Eurasia, such as the north of western Europe and southeast Asia [ 11 , 12 , 13 ]. In addition, the highly pathogenic AIV strains that caused the mass death of poultry in 2005 in the south of western Siberia turned out to be phylogenetically similar to the strains that caused the mass death of birds on Qinghai Lake in northern China in the same year [ 14 , 15 ]. This indicates the presence of diversified transmission routes for type A influenza viruses via migratory birds within the Eurasian continent that cross in the south of western Siberia.…”

Section: Introductionmentioning

confidence: 99%

Stable Isotope Analysis Reveals Common Teal (Anas crecca) Molting Sites in Western Siberia: Implications for Avian Influenza Virus Spread

Druzyaka,

Sharshov

et al. 2024

Microorganisms

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The wetlands of southwestern Siberia (SWS) are a crossroads of bird migration routes, bringing avian influenza (AIV) strains that were previously isolated in different regions of the continent to Siberia. It is known that Anseriformes that breed in SWS migrate for the winter to central Hindustan or further west, while their migration routes to southeast Asia (SEA) remain unconfirmed. Here, we mapped the molting sites of the migrating Common Teals (Anas crecca) via analyzing stable hydrogen isotope content in feathers of hunters’ prey and supplemented the analysis with the genetic structure of viruses isolated from teals in the same region. Post-breeding molt of autumn teals most likely occurred within the study region, whereas probable pre-breeding molting grounds of spring teals were in the south of Hindustan. This link was supported by viral phylogenetic analysis, which showed a close relationship between SWS isolates and viruses from south and southeast Asia. Most viral segments have the highest genetic similarity and the closest phylogenetic relationships with viruses from teal wintering areas in southeast Asian countries, including India and Korea. We assume that the winter molt of SWS breeding teals on the Hindustan coast suggests contacts with the local avifauna, including species migrating along the coast to SEA. Perhaps this is one of the vectors of AIV transmission within Eurasia.

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Section: Introductionmentioning

confidence: 99%

Stable Isotope Analysis Reveals Common Teal (Anas crecca) Molting Sites in Western Siberia: Implications for Avian Influenza Virus Spread

Druzyaka,

Sharshov

et al. 2024

Microorganisms

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“…1) произо-шла эпизоотическая вспышка, вызванная HPAI / H5N1 генотипа 2.2 [17][18][19][20][21][22][23][24][25][26][27]. Спустя всего два месяца данный генетический вари-ант вируса H5N1 был выявлен на Юге За-падной Сибири [17][18][19][20][21][22][23][24][25][26][27] [38], принадлеж-ность эпизоотически актуальному Джунгар-скому пролётному руслу [38][39][40], чрезвы-чайно высокая плотность гнездовых коло-ний и популяций птиц интразональных при-брежно-озёрных и болотных экосистем в окружении сухих степей Алтайско-Саянской горной страны [40] делают оз. Убсу-Нур ключевой точкой Северной Евразией для мониторинга вируса гриппа А птиц [2,4,8,37].…”

Section: Introductionunclassified

Results of Long-Term (2006-2016) Avian Influenza Surveillance in Wild Birds of Uvs Nuur Lake

Шестопалов¹,

Sharshov²,

Варкентин³

et al. 2016

Ûg Ross.: èkol. razvit.

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Резюме. Цель: Проведение анализа результатов многолетнего мониторинга вируса гриппа птиц в одной из ключевой точек Северной Евразии -оз. Убсу-Нур, Республика Тыва. Методы. Проведен анализ доступных источников и результатов собственных исследований. Для построения филогенетической дендрограммы использована программа MEGA 5.2. Топология дерева восстановлена при помощи метода присоединения соседей. Эволюционные расстояния рассчитаны с применением метода максимального правдоподобия. До-стоверность оценивалась посредством бутстреп-анализа (1000 репликаций). Результаты. Проведен био-географический анализ котловины Больших Озер и сделан обзор литературы и собственных результатов исследований циркуляции и молекулярной эпидемиологии высокопатогенного вируса гриппа H5N1 на озере Убсу-Нур. Заключение. Многолетние наблюдения на озере Убсу-Нур выявили важную роль данного биогео-ценоза для сохранения и распространения вируса гриппа А в популяциях диких птиц. Плановый эколого-вирусологический мониторинг является основой для корректных выводов о динамике эпизоотических процес-сов, контроля инфекции, а также для оценки эпидемического и пандемического потенциала новых вирусных штаммов. Ключевые слова: вирус гриппа А, субтип, фенотип, экология вирусов, птицы, миграции, Убсу-Нур.Формат цитирования: Шестопалов А.М., Шаршов К.А., Варкентин А.В., Юшков Ю.Г., Леонов С.В., Галкина И.В., Арчимаева Т.П., Ирза В.Н., Щелканов М.Ю., Гаджиев А.А., Магомедова М.З. Итоги многолетнего (2006-2016 г.г.) мониторинга вируса гриппа А птиц на озере Убсу-Нур // Юг России: экология, развитие. 2016. Т.11, N3. C.106-119. DOI: 10.18470/1992DOI: 10.18470/ -1098DOI: 10.18470/ -2016 RESULTS OF LONG-TERM (2006-2016) AVIAN INFLUENZA SURVEILLANCE IN WILD BIRDS OF UVS NUUR LAKEThe aim is to analyze the long-term results of the avian influenza virus surveillance monitoring of influenza virus in birds of one of the key Northern Eurasia points -Lake. Uvs Nuur, the Republic of Tyva. Methods. The analysis of the available sources and our own research results is conducted. We used MEGA 5.2 software to construct a phylogenetic dendrogram. Tree topology is constructed by the method of maximum likelihood. Genetic distance matrix is calculated using the Kimura two-parameter metric method. Results. We conducted a biogeographical analysis of the Great Lakes basin, and an overview of the literature and the original results of highly pathogenic H5N1 influenza circulation and molecular epidemiology at Uvs Nuur Lake. Conclusion. Long-term observations at Lake Uvs Nuur revealed the important role of the biogeocoenose for the preservation and evolution of influenza A virus in wild bird populations. Planned ecological and virological monitoring is the basis for correct conclusions about the dynamics of epizootic process, infection control, as well as for the evaluation of the epidemic and pandemic potential of novel viral strains.

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“…Since 1997, when the first lethal case was recorded in a human who died from an AIV-induced disease, a total of 320 humans were infected and 193 died from it by August 14, 2007 [8]. Combination of such characteristics as adaptation to wild migrating birds and possible high pathogenicity for mammals makes the Qinghai-like viruses, first described in 2005 [1], a potentially pandemic agent. H5N1 avian influenza in humans can be characterized as primary viral pneumonia leading to the development of the respiratory distress syndrome, infectious toxic shock, and multiorgan failure.…”

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Pathogenesis of Infectious Disease of Mice Caused by H5N1 Avian Influenza Virus

et al. 2008

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Highly pathogenic influenza virus H5N1 found in Western Siberia is genetically related to viruses that circulated in Southeast Asia in 2003–2005

Cited by 6 publications

References 8 publications

Stable Isotope Analysis Reveals Common Teal (Anas crecca) Molting Sites in Western Siberia: Implications for Avian Influenza Virus Spread

Stable Isotope Analysis Reveals Common Teal (Anas crecca) Molting Sites in Western Siberia: Implications for Avian Influenza Virus Spread

Results of Long-Term (2006-2016) Avian Influenza Surveillance in Wild Birds of Uvs Nuur Lake

Pathogenesis of Infectious Disease of Mice Caused by H5N1 Avian Influenza Virus

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