Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Kuchipudi, Suresh V.; Tellabati, Meenu; Sebastian, Sujith; Löndt, Brandon Z.; Jansen, Christine A.; Vervelde, Lonneke; Brookes, Sharon M.; Brown, Ian H.; Dunham, Stephen; Chang, Kin-Chow

doi:10.1186/s13567-014-0118-3

Cited by 92 publications

(84 citation statements)

References 66 publications

(72 reference statements)

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“…Freeranged flocks have been identified to be more likely exposed to wild birds carrying the LPAI strains rather than commercial poultry flocks, thus providing these free-range birds with constant challenge and immunity maintenance [36]. It has been established that there are other media through which these viruses can be maintained, sustained, and perpetuated in nature, especially in Africa [17][18][19][20][21]. Analyses and comparative assessments of documented data of HPAI H5N1 outbreaks in poultry over a period of 11 years (2006-2016) in Egypt and Nigeria show a progressive increase in the number of outbreaks in poultry; from 2006 to 2008 to the outbreaks in subsequent years [26,28].…”

Section: Factors Responsible For Persistence Of Hpai H5n1 In Africamentioning

confidence: 99%

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Public health concerns of highly pathogenic avian influenza H5N1 endemicity in Africa

Fasanmi¹,

Odetokun²,

Balogun³

et al. 2017

Vet World

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Highly pathogenic avian influenza virus (HPAIV) H5N1 was first officially reported in Africa in 2006; thereafter this virus has spread rapidly from Nigeria to 11 other African countries. This study was aimed at utilizing data from confirmed laboratory reports to carry out a qualitative evaluation of the factors responsible for HPAI H5N1 persistence in Africa and the public health implications; and to suggest appropriate control measures. Relevant publications were sought from data banks and repositories of FAO, OIE, WHO, and Google scholars. Substantiated data on HPAI H5N1 outbreaks in poultry in Africa and in humans across the world were mined. HPAI H5N1 affects poultry and human populations, with Egypt having highest human cases (346) globally. Nigeria had a reinfection from 2014 to 2015, with outbreaks in Côte d’Ivoire, Ghana, Niger, Nigeria, and Burkina Faso throughout 2016 unabated. The persistence of this virus in Africa is attributed to the survivability of HPAIV, ability to evolve other subtypes through genetic reassortment, poor biosecurity compliance at the live bird markets and poultry farms, husbandry methods and multispecies livestock farming, poultry vaccinations, and continuous shedding of HPAIV, transboundary transmission of HPAIV through poultry trades; and transcontinental migratory birds. There is, therefore, the need for African nations to realistically reassess their status, through regular surveillance and be transparent with HPAI H5N1 outbreak data. Also, it is important to have an understanding of HPAIV migration dynamics which will be helpful in epidemiological modeling, disease prevention, control and eradication measures.

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Section: Factors Responsible For Persistence Of Hpai H5n1 In Africamentioning

confidence: 99%

“…Other potential sources suggested include illegal movement of infected poultry and products, multispecies (pig, duck, etc.) farming, and poor biosecurity compliance level in live bird markets (LBMs) [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Public health concerns of highly pathogenic avian influenza H5N1 endemicity in Africa

Fasanmi¹,

Odetokun²,

Balogun³

et al. 2017

Vet World

View full text Add to dashboard Cite

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“…PRRSV reduces STAT2 protein to inhibit this pathway. proinflammatory response in chickens via inhibition of STAT3 phosphorylation (Kuchipudi et al, 2014).…”

Section: Stat Signaling and Functionsmentioning

confidence: 99%

“…The ORF6 product of severe acute respiratory syndrome coronavirus disrupts nuclear import of pSTAT1 by tethering KPNA2 to the endoplasmic reticulum/Golgi membrane (Frieman et al, 2007). Highly pathogenic avian influenza (HPAI) H5N1 virus inducing a strong proinflammatory response in chickens by inhibiting STAT3 phosphorylation (Kuchipudi et al, 2014). PRRSV is known to inhibit IFN-activated JAK-STAT signaling by blocking the ISGF3 nuclear translocation (Patel et al, 2010;Wang et al, 2013b).…”

Section: Prrsv Interference With Jak-stat Signalingmentioning

confidence: 99%

Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus

Yang

Zhang

2017

Veterinary Microbiology

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Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway is activated by myriad cytokines, which are involved in regulation of cell growth, proliferation, differentiation, apoptosis, angiogenesis, immunity and inflammatory response. Because of its significance in immune response, JAK-STAT pathway is often targeted by pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV causes reproductive failure in sows and respiratory disease in pigs of all ages. A typical feature of the immune response to PRRSV infection in pigs is delayed production and low titer of virus neutralizing antibodies, and weak cell-mediated immune response. One of the possible reasons for the weak protective immune response is that PRRSV interferes with cytokine-mediated JAK-STAT signaling. PRRSV inhibits interferon-activated JAK-STAT signaling by blocking nuclear translocation of STAT1 and STAT2. The mechanism is that PRRSV non-structural protein 1β (nsp1β) induces degradation of karyopherin α1 (KPNA1), a critical adaptor in nucleo-cytoplasmic transport. PRRSV also antagonizes IL6-activated JAK-STAT3 signaling via inducing degradation of STAT3. In this review, we briefly introduce JAK-STAT signaling, summarize the PRRSV interference with it, and provide perspective on the perturbation in the context of PRRSV-elicited immune response.

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“…A/H5N1 viruses can cause severe infection in chickens (Kuchipudi et al, ), and A/H7N9 virus is more prevalent and prolonged in quails and chickens compared to other species of birds (Guan et al, ; Pantin‐Jackwood et al, ). Considering that type of poultry may be a factor influencing poultry farmers' preventive behaviours and chicken is the dominant type of poultry raised in China, this study focused on commercial chicken farmers only.…”

Section: Methodsmentioning

confidence: 99%

Chinese poultry farmers' decision‐making for avian influenza prevention: a qualitative analysis

Cui

Wang

et al. 2019

Zoonoses and Public Health

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Poultry farmers faced dual risk when mutant avian influenza (AI) virus showed the zoonotic characteristics. A/H5N1 and A/H7N9 were two dominant AI virus strains that have captured the attention of the public over the years for they have been reported to bring about greater loss to poultry and human, respectively. Previous studies mainly used quantitative methods investigating either the means that poultry farmers adopted for protecting their poultry against A/H5N1 infection or the poultry farmers' self‐protective behaviours against A/H7N9 infection. We sought insights into the underlying factors influencing Chinese poultry farmers' protective behaviours in response to the dual risk of AI by a qualitative way. Semi‐structured in‐depth interviews were conducted with 25 Chinese chicken farmers recruited by purposive sampling between November 2016 and May 2017, the peak season of AI. All interviews were audio‐taped, transcribed and analysed using a grounded theory approach. From participants' experiences, we revealed five main themes: Measures adopted for protecting poultry and farmers, Emotional response to the AI epidemic, Perceived risk of AI, Perceived effectiveness of the preventive measures adopted and Perceived self‐efficacy to take preventive measures. The information of AI outbreak directly triggered Chinese chicken farmers' emotional response and thereafter preventive actions. Compared to the perceived risk of poultry infection with A/H5N1 which mainly connected to economic loss, participants perceived much lower risk of human infection with A/H7N9. AI epidemic information played a key role triggering poultry farmers' response behaviours. Chinese poultry farmers weighted more attention on the risk of poultry infection which was highly associated with economic losses. The government should build and improve an early AI warning and information transmission network to poultry farmers. Further reinforcement of related self‐protective and preventive knowledge training towards poultry farmers is necessary.

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Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Cited by 92 publications

References 66 publications

Public health concerns of highly pathogenic avian influenza H5N1 endemicity in Africa

Public health concerns of highly pathogenic avian influenza H5N1 endemicity in Africa

Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus

Chinese poultry farmers' decision‐making for avian influenza prevention: a qualitative analysis

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