Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

Abstract

Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid–state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A–G (1–7), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7–7.3 μM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity.

Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi

“…They also reported that the compounds Nortryptoquivaline, 2,4-dihydroxy-3-methylacetophenone, chevalone C from Neosartorya siamensis exhibited strong effects against DNA and intracellular accumulation in lung cancer cells as well as induced cytotoxicity against the cancer cells and the cell death in lung cancer. The 3-hydroxy, benzenemethanol, 2-bromogentisyl alcohol, 2-chlorogentisyl alcohol, and Epoxydon 6-dehydroxy-6-bromogabosine C compounds purified from the secondary metabolic of P. concentricum exhibited anti-cancer activity against the human caucasian colon adenocarcinoma cells line [18]. The pentacyclic decalinoylspirotetramic acid and pyrenosetin D from Pyrenochaetopsis sp.…”

“…The marine environment which includes the water, sediments, invertebrates, driftwood as well as marine mammals represents a rich source of fungi [18]. Up-to-date studies have estimated there are more than 10,000 marine fungal species, including the fungi belong to the Ascomycota and Basidiomycota phyla [22].…”

“…isolated from the surface of marine red algae, Lomentaria catenata, The compounds exhibited anti-cancer activity against human glioblastoma and non-small cell lung cancer Apoptosis-resistant cells, and distinct cancer cell lines. The compounds exhibited anti-cancer activity against the human caucasian colon adenocarcinoma cells line [18] Penicillium sp. isolated from marine sediments (Z)-Octadec-9-enamide (oleamide) IC 50 = 22.79 µg/mL Anti-cancer activity against breast cancer cells.…”

Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources

“…With the ADMET results, quinadoline B indicated high gastrointestinal (GI) absorption, low blood-brain barrier penetrability, and high drug-likeness ( Quimque et al, 2020 ). Quinadoline B has also been extracted from Aspergillus giganteus Wehmer, 1901 NTU967 which was isolated from the marine alga, Ulva lactuca ( Chen JJ. et al, 2020 ), and Aspergillus sp.…”

Potensi Metabolit Sekunder Dari Jamur Yang Berasosiasi Dengan Spons Laut Sebagai Sumber Senyawa Antikanker

“…Tabel 1. [22][23][24] Tabel 1 Aktivitas sitotoksik dari metabolit jamur yang berasosiasi dengan spons laut [22][23][24][25][26][27] No Metabolit yang diisolasi…”