Highly Oxygenated 11‐Keto‐β‐boswellic Acid Analogues and Their Anti‐Inflammatory Potential

Abstract

Novel 9‐α‐hydroxy‐11‐keto‐β‐boswellic acid analogues constituted with versatile functionality at ring A have been synthesized for the first time from 3‐O‐acetyl‐11‐keto β‐boswellic acid (AKBBA) and described herein. The anti‐malarial potential of endoperoxide benzyl ester was evaluated against the malarial parasite and exhibited reasonable anti‐malarial activity (2 μM). Anti‐inflammatory potential of all new analogues was examined against proinflammatory cytokine, Tumor Necrosis Factor‐alpha (TNF‐α) and one of them was found to possess similar activity as that of AKBBA.

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“…9-αhydroxy-11-keto-β-Boswellic acid analogues constituted with variable functionality at ring A have been synthesized from 3-O-acetyl-11-keto-β-Boswellic acid. This compound has been investigated to have an anti-inflammatory activity as opposed to the pro-inflammatory cytokine and tumor necrosis factor-α, which results in proving the anti-inflammatory potential of this derivative of Boswellic acid 33,34 .…”

Synthesis of α/β-Aromatic Peroxy Thiols Mediated by Iodine Source

“…Peroxygenated compounds are present in many important natural products and biologically active drugs. It is widely used in the fields of chemistry, pesticides, and pharmaceutical chemistry; has some biological activity in the field of medicine; − and also has some application value in the field of materials science. − Furthermore, the O–O bond of the peroxide structure can be found on many reactants. Under the influence of heat, transition metal catalysts, or radiation, the relatively weak O–O bond is cleaved, allowing further synthesis of alcohols, aldehydes, ketones, and other substances. − The bifunctional groups of olefins can rapidly form C–S bonds to synthesize alkyl/arylthiocompounds. − The synthesis methods of peroxides are very diverse, and the bifunctionalization of olefins is often used to synthesize peroxides; some cheap metals are often used as catalysts for reactions.…”