Highly monodisperse colloidal coacervates based on a bioactive lactose-modified chitosan: From synthesis to characterization

Furlani, Franco; Sacco, Pasquale; Marsich, Eleonora; Donati, Ivan; Paoletti, Sergio

doi:10.1016/j.carbpol.2017.06.097

Cited by 23 publications

(42 citation statements)

References 31 publications

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“…In a previous study we have investigated a fast synthesis method to realize polymer-modified AuNPs using dycarboxylic PEG, collagen or bisphosphonate (BPO) as stabilizers in order to demonstrate high stability and efficacy under realistic biomedical conditions 5,6,7,8 . Other authors have synthetized hybrid metal nanoparticles based on chitosan and chitosan-derivatives as sugar stabilizers for various applications in the field of the nanomedicine 9,10,11,12,13 .…”

Section: Introductionmentioning

confidence: 99%

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Lactose-Modified Chitosan Gold(III)-PEGylated Complex-Bioconjugates: From Synthesis to Interaction with Targeted Galectin-1 Protein

et al. 2018

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Galectins (Gal) are a family of glycan-binding proteins characterized by their affinity for β-galactosides. Galectin-1 (Gal-1), a dimeric lectin with two galactoside-binding sites, regulates cancer progression and immune responses. Coordination chemistry has been engaged to develop versatile multivalent neoglycoconjugates for binding Gal-1. In this study we report a fast and original method to synthesize hybrid gold nanoparticles in which a hydrochloride lactose-modified chitosan, named CTL, is mixed with dicarboxylic acid-terminated polyethylene glycol (PEG), leading to shell-like hybrid polymer-sugar-metal nanoparticles (CTL-PEG-AuNPs). The aim of this paper is to preliminarily study the interaction of the CTL-PEG-AuNPs with a target protein, namely, Gal-1, under specific conditions. The molecular interaction has been measured by Transmission Electron Microscopy (TEM), UV-vis, and Raman Spectroscopy on a large range of Gal-1 concentrations (from 0 to 10 M). We observed that the interaction was strongly dependent on the Gal-1 concentration at the surface of the gold nanoparticles.

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Section: Introductionmentioning

confidence: 99%

“…Schott capillary viscometer. A buffer solution composedby 20 mM AcOH/AcNa, pH 4.5, and 100 mM NaCl was used as solvent11 . The resulting was 511 mL/g.…”

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confidence: 99%

Lactose-Modified Chitosan Gold(III)-PEGylated Complex-Bioconjugates: From Synthesis to Interaction with Targeted Galectin-1 Protein

et al. 2018

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“…A pH sensitive polymer gel can be prepared by chemically linking d , l -lactic acid with -NH 2 groups of the chitosan for an application in the drug delivery to the different regions of the gastrointestinal tract (GIT) [22]. Lactose modification of the chitosan backbone (1-deoxylactit-1-yl chitosan) has been used in combination with the polyvalent ion tripolyphosphate (TPP) to form colloidal coacervates though polyionic interactions, forming highly uniform and small (200 nm diameter) nanoparticles [23,24]. …”

Section: Modification Of Chitosanmentioning

confidence: 99%

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

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The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

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“…CTL is a lactose-derivative of chitosan showing an improved solubility at neutral pH [17] and an interesting bioactivity toward mammalian cells [18,19]. This engineered polysaccharide behaves as a polycation in acidic conditions [17], as a result of which it is prone to promote electrostatic interactions with oppositely charged ions or macromolecules depending on the ionic strength [13,[20][21][22].…”

Section: Of 12mentioning

confidence: 99%

“…The phase behavior of two oppositely charged polymers in a mixture depends primarily on their molecular properties (i.e., molecular weight and charge density), polymers' weight ratio and physical-chemical features of the surrounding environment (i.e., pH, ionic strength and temperature) [4,5]. A plethora of micro-/nano-structures assembled via complex coacervation are documented in the literature, for instance stimuli responsive nanocapsules made of alginate and chitosan [6,7] or those based on the interaction between chitosan and hyaluronic acid [8,9], polysaccharides and proteins [5,[10][11][12], or simple coacervation involving a single polymer and a multivalent ion [13].…”

Section: Introductionmentioning

confidence: 99%

Binary Solutions of Hyaluronan and Lactose-Modified Chitosan: The Influence of Experimental Variables in Assembling Complex Coacervates

et al. 2020

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A miscibility study between oppositely charged polyelectrolytes, namely hyaluronic acid and a lactose-modified chitosan, is here reported. Experimental variables such as polymers’ weight ratios, pH values, ionic strengths and hyaluronic acid molecular weights were considered. Transmittance analyses demonstrated the mutual solubility of the two biopolymers at a neutral pH. The onset of the liquid-liquid phase separation due to electrostatic interactions between the two polymers was detected at pH 4.5, and it was found to be affected by the overall ionic strength, the modality of mixing and the polymers’ weight ratio. Thorough Dynamic Light Scattering (DLS) measurements were performed to check the quality of the formed coacervates by investigating their dimensions, homogeneity and surface charge. The whole DLS results highlighted the influence of the hyaluronic acid molecular weight in affecting coacervates’ dispersity and size.

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Highly monodisperse colloidal coacervates based on a bioactive lactose-modified chitosan: From synthesis to characterization

Cited by 23 publications

References 31 publications

Lactose-Modified Chitosan Gold(III)-PEGylated Complex-Bioconjugates: From Synthesis to Interaction with Targeted Galectin-1 Protein

Lactose-Modified Chitosan Gold(III)-PEGylated Complex-Bioconjugates: From Synthesis to Interaction with Targeted Galectin-1 Protein

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Binary Solutions of Hyaluronan and Lactose-Modified Chitosan: The Influence of Experimental Variables in Assembling Complex Coacervates

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