Highly modular hepatitis B virus-like nanocarriers for therapeutic protein encapsulation and targeted delivery to triple negative breast cancer cells

Abstract

Protein therapeutics offer enormous clinical impact in treating a variety of diseases by offering high selectivity with limited off-target effects. However, delivery challenges severely reduce functional proteins from reaching their...

Vault, viral, and virus-like nanoparticles for targeted cancer therapy

“…77 For instance, the engineered hepatitis B VLP delivery platform exhibited improved uptake and toxicity in epidermal growth factor receptor-overexpressing triple negative breast cancer cells in contrast to non-malignant breast epithelial cells. 78 Despite significant advancements in cancer therapy using viral NPs, there are still challenges pertaining to the multi-drug resistance, complexity and heterogeneity of tumor biology, incomplete understanding of nano-bio interactions, immunogenicity, and biological instability. [79][80][81] However, these NPs continue to be an area of active research in cancer therapy as exemplified by multifunctional plant virus NPs, which show exceptional promise in targeting breast cancer tumors.…”