Highly mineralized chitosan-based material with large size, gradient mineral distribution and hierarchical structure

Pei, Boying; Wang, Zhengke; Nie, Jingyi; Hu, Qiaoling

doi:10.1016/j.carbpol.2018.12.087

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…209 Given that chitosan is often biocompatible in various applications in the mammalian body (and can be degraded and cleared from the body), researchers are motivated by the potential to use chitosan in biomedical fields. 39,40,210 CaCO 3 is often used as a sacrificial core for drug delivery devices, 164,211 and chitosanbased hydrogels are a promising medical development. 212−215 Through controlled synthesis of functionalized chitosans, an array of relevant chemical moieties for hypothesis testing can be prepared.…”

Section: Chitosan Hydrogels As Canvas For Studies Of Caco 3 Nucleationmentioning

confidence: 99%

“…A recent review of many chitosan derivatives pertinent to biomedical applications highlights many opportunities for making new synthetic materials . Given that chitosan is often biocompatible in various applications in the mammalian body (and can be degraded and cleared from the body), researchers are motivated by the potential to use chitosan in biomedical fields. ,, CaCO 3 is often used as a sacrificial core for drug delivery devices, , and chitosan-based hydrogels are a promising medical development. − …”

Section: Chitosan Hydrogels As Canvas For Studies Of Caco3 Nucleationmentioning

confidence: 99%

“…We discuss chitosan, a synthetically deacetylated chitin, as a promising and versatile material that can be derivatized for systematic, quantitative studies to establish kinetic and thermodynamic drivers to mineralization. This understanding will make it possible to build conceptual and computational models that are grounded in experimentation for how functional groups, as individual species or through cooperative interactions, modulate controlled mineralization in animals. ,− The insights thus generated can further be applied to develop novel biomaterials for diverse applications. − …”

Section: Introductionmentioning

confidence: 99%

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Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization

et al. 2023

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A mechanistic understanding of how macromolecules, typically as an organic matrix, nucleate and grow crystals to produce functional biomineral structures remains elusive. Advances in structural biology indicate that polysaccharides (e.g., chitin) and negatively charged proteoglycans (due to carboxyl, sulfate, and phosphate groups) are ubiquitous in biocrystallization settings and play greater roles than currently recognized. This review highlights studies of CaCO3 crystallization onto chitinous materials and demonstrates that a broader understanding of macromolecular controls on mineralization has not emerged. With recent advances in biopolymer chemistry, it is now possible to prepare chitosan-based hydrogels with tailored functional group compositions. By deploying these characterized compounds in hypothesis-based studies of nucleation rate, quantitative relationships between energy barrier to crystallization, macromolecule composition, and solvent structuring can be determined. This foundational knowledge will help researchers understand composition-structure-function controls on mineralization in living systems and tune the designs of new materials for advanced applications.

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Section: Chitosan Hydrogels As Canvas For Studies Of Caco 3 Nucleationmentioning

confidence: 99%

Section: Chitosan Hydrogels As Canvas For Studies Of Caco3 Nucleationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization

et al. 2023

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“…The nanostructure of nano-hydroxyapatite can provide an amazing interface effect, significantly improving its biomechanical strength and increasing its surface bioactivity (Ruan et al, 2018). In addition, some polymers, including synthetic and natural polymers, with good flexibility and degradability have gradually gained attention as promising candidate materials for compounding with hydroxyapatite (Hassanajili et al, 2019;Pei et al, 2019;Cakmak et al, 2020). Compared with synthetic polymers, natural polymers have attracted more attention in bone tissue engineering due to their unique biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Properties of 3D-Printed Cervical Interbody Fusion Cage With Novel SF/nHAp Composites

Chen

Meng

et al. 2021

Front. Mater.

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Anterior cervical discectomy and fusion (ACDF) is a commonly used surgical method for the treatment of cervical spondylosis. As ACDF surgery is widely used in clinics, identifying suitable materials to design and prepare cervical interbody fusion cages is a hot research topic. Here, we describe a new three-dimensional (3D) printing approach to create stretchable and tough silk fibroin/nano-hydroxyapatite (SF/nHAp) composites with tunable mechanical properties. The compressive strength of the novel composites with biomimetic structure could reach more than 128 MPa. More importantly, the composites were prepared using 30% silk fibroin and 70% hydroxyapatite, a composition similar to the human bone tissue. Finite element analysis results indicate that the stress distribution of SF/nHAp composite cervical interbody fusion cages in vivo is more uniform than that of commercial Ti alloy cages. This study evaluates the effectiveness of SF/nHAp composites for application in cervical interbody fusion cages and in the field of bone tissue engineering.

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“…31 Recently, organic-inorganic composites have been proposed by co-precipitation. 32,33 Unfortunately, controlling the orientation and pattern design have remained as major challenges, which is in contrast to the hierarchical and ordered structures that form naturally in nacre.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization

Liu

et al. 2021

Preprint

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Here introduced a route for the synthesis of 3D structures that display a mechanical strength that competes with that of the toughest materials found in nature. Following the “brick-and-mortar” biomineralization typical of nacre, self-stratified, periodic materials are obtained by one-step ion diffusion gradient and hydrogelation of nanochitin with simultaneous mineral coprecipitation. Specifically, under appropriate electrolyte conditions, hydroxyapatite (HA) microspheres grow in an organic network formed from partially deacetylated chitin nanofibers (NCh), resulting in periodic stacking of mineralized (HA) and non-mineralized (NCh) layers. By directional diffusion, customizable 3D shapes are self-assembled and demonstrated to function as optical waveguides with selective light transmission at interfaces. Upon hot pressing, the resulting solid structures exhibit a superb mechanical performance while being biocompatible (tested with chondrogenic ATDC5 cells as a model for physiological mineralization). Overall, a shape-controlled, one-pot biomineralization method was proposed that achieves hierarchical, periodic and strong “nacre-like” structures suitable as biomedical material.

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Highly mineralized chitosan-based material with large size, gradient mineral distribution and hierarchical structure

Cited by 12 publications

References 30 publications

Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization

Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization

Biomechanical Properties of 3D-Printed Cervical Interbody Fusion Cage With Novel SF/nHAp Composites

Synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization

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Highly mineralized chitosan-based material with large size, gradient mineral distribution and hierarchical structure

Cited by 12 publications

References 30 publications

Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO3Biological Crystallization

Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO3Biological Crystallization

Biomechanical Properties of 3D-Printed Cervical Interbody Fusion Cage With Novel SF/nHAp Composites

Synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization

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Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization

Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO₃Biological Crystallization