Highly mechanosensitive ion channels from graphene-embedded crown ethers

Fang, Alta; Kroenlein, Kenneth G.; Riccardi, Daniela; Smolyanitsky, Alex

doi:10.1038/s41563-018-0220-4

Cited by 99 publications

(147 citation statements)

References 44 publications

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“…It is worth noting that binding Gibbs free energy minimum for Na + in Figure 15 is located away from the plane of ether-containing membrane due to a more stable hydration shell. For ions trapping in the ether-like pore structure, Fang et al [179] yielded the following permeation selectivity at small transmembrane bias using a Langmuir adsorption model The trapped K + was also reported by Kang et al, [178] and they discovered the monolayer graphene nanopore modified by the four-oxygen ring of 3.9Å having the ability to make a selectivity up to 1000-fold of K + from Na + under external electric field.…”

Section: Ion Selectivity Of Modified Nanochannelsmentioning

confidence: 78%

“…The trapped K + was also reported by Kang et al, [178] and they discovered the monolayer graphene nanopore modified by the four-oxygen ring of 3.9Å having the ability to make a selectivity up to 1000-fold of K + from Na + under external electric field. For ions trapping in the ether-like pore structure, Fang et al [179] yielded the following permeation selectivity at small transmembrane bias using a Langmuir adsorption model…”

Section: Ion Selectivity Of Modified Nanochannelsmentioning

confidence: 99%

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Structure and Transport Properties of Water and Hydrated Ions in Nano‐Confined Channels

Zhu

Wang

Fan

et al. 2019

Advcd Theory and Sims

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Nano-confined flow is ubiquitous in modern engineering and biomedical applications. As the peculiar phenomena of nano-confined flow were continuously reported and traditional theories failed to describe them accurately, simulation efforts have been made to gain deeper insight. The objective of this paper is to provide an overview of the recent progress on nano-confined flow, including water flow and hydrated ions transport. This report starts with the water behavior under nano-confinement, summarizing the water structures, flow properties and their dependence on wall wettability, channel size, etc. The report also presents the efforts made to modify the existing theories to describe nano-confined flows. Then, the report goes to the hydrated ions. The dehydration process of hydrated ions and ions sieving are discussed in detail, and the effects of membrane surface charge, grafting functional groups, and external field on ions transport are reviewed. In this Progress Report, the transport properties of water and hydrated ions in nano-confined channels are highlighted, which is critical to the design and application of nanofluidic devices, such as nanofiltration membranes, biosensors, and other related fields.

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Section: Ion Selectivity Of Modified Nanochannelsmentioning

confidence: 78%

Section: Ion Selectivity Of Modified Nanochannelsmentioning

confidence: 99%

Structure and Transport Properties of Water and Hydrated Ions in Nano‐Confined Channels

Zhu

Wang

Fan

et al. 2019

Advcd Theory and Sims

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“…Transport of target ions and/or molecules through the nanoporous 2D nanomaterial‐based membrane is primarily determined by the size of nanopores . Similar to the fore‐mentioned size‐exclusion theory, membrane nanopores allow small‐diameter components to transport but block the large hydrated ions and/or molecules .…”

Section: Mechanismmentioning

confidence: 99%

Two dimensional nanomaterial‐based separation membranes

Zhang

Zhan

et al. 2019

Electrophoresis

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Two dimensional nanomaterials including graphene, hexagonal boron‐nitride, molybdenum disulfide, etc., provide immense potentials for separation applications. However, the tradeoff between selectivity and permeability in choosing 2D nanomaterial‐based membrane is inevitable, limiting the progress on separation efficiency for mass industrial applications. To target these issues, versatile strategies such as the rational design of predefined interlayer channels, membrane nanopores, and reasonable functionalization, as well as new mechanisms have been emerged. In this review, we introduce the recent progress on separation mechanisms of 2D nanomaterial‐based membranes with different structures (including the interlayer channels type and the membrane nanopores type) and their inner surface functionalization. Moreover, the interface designs are discussed, in terms of employing dynamic liquid–liquid/liquid–gas interfaces, to advance the selectivity and permeability of the membranes. We further discuss the variety of separation applications based on 2D nanomaterial‐based membranes. The authors hope this review will inspire the active interest of many scientists in the area of the development and application of membrane science.

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“…In addition, 2D-material-based ion channels sensitively gated by tensile mechanical strain applied to the membrane were recently predicted [10,11]. † Present address: BIOVIA, Dassault Systèmes, San Diego, CA, USA.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, pore dilation is assumed to be radial throughout the pore edge. Moreover, hexagonal symmetry yields nearly identical permeability responses to uniaxial tensile strains applied along different directions [10]. More generally, the assumption of a nearly circular pore edge underlies the well-accepted paradigm of ion-pore interactions, in which the pore is assumed to interact with permeating ions as a single isotropic entity.…”

Section: Introductionmentioning

confidence: 99%

Ion transport across solid-state ion channels perturbed by directed strain

et al. 2020

Self Cite

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We combine quantum-chemical calculations and molecular dynamics simulations to consider aqueous ion flow across non-axisymmetric nanopores in monolayer graphene and MoS2. When the pore-containing membrane is subject to uniaxial tensile strains applied in various directions, the corresponding permeability exhibits considerable directional dependence. This anisotropy is shown to arise from directed perturbations of the local electrostatics by the corresponding pore deformation, as enabled by the pore edge geometries and atomic compositions. By considering nanopores with ionic permeability that depends on the strain direction, we present model systems that may yield a detailed understanding of the structure-function relationship in solid-state and biological ion channels. Specifically, the observed anisotropic effects potentially enable the use of permeation measurements across strained membranes to obtain directional profiles of ion-pore energetics as contributed by groups of atoms or even individual atoms at the pore edge. The resulting insight may facilitate the development of subnanoscale pores with novel functionalities arising from locally asymmetric pore edge features.

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Highly mechanosensitive ion channels from graphene-embedded crown ethers

Cited by 99 publications

References 44 publications

Structure and Transport Properties of Water and Hydrated Ions in Nano‐Confined Channels

Structure and Transport Properties of Water and Hydrated Ions in Nano‐Confined Channels

Two dimensional nanomaterial‐based separation membranes

Ion transport across solid-state ion channels perturbed by directed strain

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