Highly luminescent gold nanoparticles: effect of ruthenium distance for nanoprobes with enhanced lifetimes

Osborne, Shani A. M.; Pikramenou, Zoe

doi:10.1039/c5fd00108k

Cited by 14 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…141 In fact, conjugation of Ru(II) complexes to AuNPs via alkane thiols has been shown to result in highly luminescent nanoparticles in which the tethered Ru(II) complexes possess longer luminescence lifetimes than free counterparts. 410,412 Within the Gunnlaugsson research group such Ru(II)nanoconjugates of 4 nm and 15 nm diameter (conjugates 107 -111 illustrated in Fig. 44) have been used for luminescence imaging within live cells.…”

Section: 106mentioning

confidence: 99%

The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications

et al. 2017

View full text Add to dashboard Cite

Ruthenium(ii) [Ru(ii)] polypyridyl complexes have been the focus of intense investigations since work began exploring their supramolecular interactions with DNA. In recent years, there have been considerable efforts to translate this solution-based research into a biological environment with the intention of developing new classes of probes, luminescent imaging agents, therapeutics and theranostics. In only 10 years the field has expanded with diverse applications for these complexes as imaging agents and promising candidates for therapeutics. In light of these efforts this review exclusively focuses on the developments of these complexes in biological systems, both in cells and in vivo, and hopes to communicate to readers the diversity of applications within which these complexes have found use, as well as new insights gained along the way and challenges that researchers in this field still face.

show abstract

Section: 106mentioning

confidence: 99%

The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…showed an of the IrSH quantum yield to 12% which is a similar increase observed for the coated 13 and 100 nm gold particles within the expected error of the quantum yield measurement. The effect of the coating of the fluorinated surfactant on metal complexes at different distances from the gold nanoparticle has been shown in a different study [38]. The luminescence lifetime of the IrS•AuNP100 aerated solution showed a biexponential decay fitted for 90 ns (10%) and 400 ns (90%), significantly higher than the IrSAc complex in water and similar with that in the presence of the surfactant.…”

Section: Preparation and Characterization Of Irs•aunpmentioning

confidence: 89%

Tailoring Iridium Luminescence and Gold Nanoparticle Size for Imaging of Microvascular Blood Flow

Rogers

Jeffery

Claire

et al. 2017

Nanomedicine (Lond.)

Self Cite

View full text Add to dashboard Cite

Aim:Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow. Materials & methods: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues. Results: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle. Conclusion: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.

show abstract

“…The same authors then investigated the effect of the distance of the thiol‐functionalized ruthenium luminescent center from the gold surface on the luminescence properties of the nanoparticles. [ 73 ] Three ruthenium probes with different length spacer units ( Ru35 , Ru36 , and Ru37 ) were attached on Zonyl pre‐coated AuNPs of different sizes (13, 50, and 100 nm). An enhanced luminescence lifetime was obtained upon attachment with an increase of 20%, 40%, and 70% depending on the spacer length: the longer the spacer chain was, the higher the luminescence lifetime was.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis

2020

View full text Add to dashboard Cite

Ru(II) metal center. [2] They absorb light and emit wavelength within the red and the near infrared (NIR) spectral regions and possess large Stokes shift, long luminescence lifetime, and potential twophoton (2P) absorption properties. These characteristics have made them highly desirable across numerous research fields such as catalysis, [3] solar energy, [4] sensors [5] and now across the biomedical field either in diagnostics as cellular imaging tools, luminescent probes of DNA structures or in therapy as new classes of anticancer drugs for chemotherapy and photosensitizers (PSs) for photodynamic therapy (PDT) or photoactivated chemotherapy (PACT). [6-11] Worthy of note, a Ru(II) polypyridyl compound (TLD1433) has recently entered phase II clinical trials in Canada for the treatment of nonmuscle invasive bladder cancer as a PS for PDT. [12] However, these complexes still suffer from some drawbacks such as poor water solubility, lack of targeting capability, nonspecific distribution, systemic toxicity and hence, low therapeutic index hampering their translation into the clinic. One strategy to address those medical challenges is to use nanomedicine. Nanomedicine is the application of sub-micron particles (i.e., nanoparticles) in the field of medicine. The materials used for the synthesis and/ or formulation of nanoparticles are extremely diverse, ranging from organic to inorganic molecules (Figure 1). [13] The unique features of nanoparticles including small size, high surface area, surface chemistry, water solubility and multifunctionality make them highly interesting for drug delivery purposes. [14,15] Owing to their size, nanoparticles can passively accumulate to solid tumors while sparing healthy cells thanks to the enhanced permeation and retention (EPR) effect. [16] The EPR effect exploits the abnormalities of tumor vasculature, namely hypervascularity, atypical vascular architecture, leaky vasculature, and lack of lymphatic drainage. This results in the efficient extravasation of nanoparticles from the tumor vasculature and their retention in the tumor interstitium. Therefore, drug incorporation into nanoparticles provides significant improvements in pharmacokinetics, solubility, toxicity, and biodistribution when compared to freely administered molecules, reducing adverse side effects observed with conventional medicine. However, to take full advantage of the EPR effect, nanoparticles must remain in circulation long enough for tumor accumulation. PEGylation, which refers to modification with poly(ethylene glycol) (PEG) chains or PEG copolymers (e.g., Jeffamine), is the most common strategy for imparting stealth properties to nanoparticles. [17] The presence of PEG enables steric stabilization Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy due to their unique photophysical, photochemical, and biological properties. For effective treatment, they must be able to penetrate tumor cells effectively and selectively. The development of nanoscale carriers capable of delivering Ru(I...

show abstract

Highly luminescent gold nanoparticles: effect of ruthenium distance for nanoprobes with enhanced lifetimes

Cited by 14 publications

References 31 publications

The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications

The development of ruthenium(ii) polypyridyl complexes and conjugates forin vitrocellular andin vivoapplications

Tailoring Iridium Luminescence and Gold Nanoparticle Size for Imaging of Microvascular Blood Flow

Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis

Contact Info

Product

Resources

About