Highly luminescent biocompatible CsPbBr<sub>3</sub>@SiO<sub>2</sub> core–shell nanoprobes for bioimaging and drug delivery

Kumar, Pawan; Patel, Madhumita; Park, Chanho; Han, Hyowon; Jeong, Beomjin; Kang, Hansol; Patel, Rajkumar; Koh, Won Gun

doi:10.1039/d0tb01833c

Cited by 74 publications

(79 citation statements)

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“…A variety of luminescent nanoparticles have been developed and engineered for specific applications of drug imaging and delivery systems 42‐44 . Functionalization of nanomaterials increases significantly its targeting properties and leads to considerable progress in the fundamental understanding, diagnosis, and treatment of cancer.…”

Section: Discussionmentioning

confidence: 99%

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

et al. 2021

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Targeted drug delivery enhances drug efficiency and selectivity without affecting normal cells. Luminescent nanoparticles can be used for tumor imaging as well as selective tumor targeting for drug delivery. In this research, LaVO4:Eu3+ was synthesized, the luminescent nanocrystal was coated by surface polymerization of levodopa in the presence of Paclitaxel (PTX), and then NL2 peptide was coupled on the surface of polymer‐coated luminescent nanoparticles. Next, the capability of the modified drug was examined by in vitro and in vivo experiments. MTT assay on SK‐BR‐3 cell line (as breast cancer cells) and fluorescent microscopy results indicate that this modification decreases significantly drug toxicity and increases its selectivity. In addition, in vivo experiments confirm more capability of the NL2‐functionalized nanocomposite for reducing tumor size, drug distribution in the body, and more aggregation of PTX in tumor tissue. Overall, it is concluded that tumor imaging is possible using luminescent LaVO4:Eu3+ core and NL2 peptide increases significantly the specificity of PTX in combination with a functionalized luminescent polymeric carrier.

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Section: Discussionmentioning

confidence: 99%

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

et al. 2021

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“…[239] CsPbBr 3 @SiO 2 core-shell composites were used as the carrier to deliver the Doxorubicin (Dox) to the HeLa cells. [110] The tests were performed in a phosphate buffered saline (PBS, pH is 7.4) solution. The process of the drug delivery is shown in Figure 22a.…”

Section: Drug Deliverymentioning

confidence: 99%

Section: Cspbbr 3 /Tio 2 For Pec Reactionmentioning

confidence: 99%

Recent Progress on Synthesis, Characterization, and Applications of Metal Halide Perovskites@Metal Oxide

Duan

Wang

Costa

2021

Adv Funct Materials

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Metal halide perovskites (MHPs) have become a promising candidate in a myriad of applications, such as light-emitting diodes, solar cells, lasing, photodetectors, photocatalysis, transistors, etc. This is related to the synergy of their excellent features, including high photoluminescence quantum yields, narrow and tunable emission, long charge carrier lifetimes, broad absorption spectrum along with high extinction absorptions coefficients, among others. However, the main bottleneck is the poor stability of the MHPs under ambient conditions. This is imposing severe restrictions with respect to their industrialized applications and commercialization. In this context, metal oxide (MO x ) coatings have recently emerged as an efficient strategy toward overcoming the stabilities issues as well as retaining the excellent properties of the MHPs, and therefore facilitate the development of the related devices' stabilities and performances. This review provides a summary of the recent progress on synthetic methods, enhanced features, the techniques to assess the MHPs@MO x composites, and applications of the MHPs@MO x . Specially, novel approaches to fabricate the composites and new applications of the composites are also reported in this review for the first time. This is rounded by a critical outlook about the current MHPs' stability issues and the further direction to ensure a bright future of MHPs@MO x .

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“…However, utilizing specialized techniques such as electrospinning, nonsolvent-induced phase separation, oxidizing agents, and blending with carbon materials, various nanostructures including nanowires, nanobers, and nanospheres have been generated. [27][28][29][30][31][32] For example, polypyrrole conducting polymer with nanosheets were formed using electrochemical reactions and chemical oxidative polymerization, which resulted in an improved electrochemical performance owing to the increased specic surface area as well as a well-aligned and interconnected structure. [33][34][35][36][37] However, there was no report on the formation of polymer nanosheets via solution casting, which is a cost-effective simple process for commercialization.…”

Section: Introductionmentioning

confidence: 99%

Substrate-independent three-dimensional polymer nanosheets induced by solution casting

Park

Lee

et al. 2021

Chem. Sci.

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Highly luminescent biocompatible CsPbBr₃@SiO₂ core–shell nanoprobes for bioimaging and drug delivery

Abstract: The encapsulation of lead halide perovskite nanocrystals with an inert protective layer against moisture and the environment is a promising approach to overcome hinderances for their practical use in optoelectronic...

Cited by 74 publications

References 80 publications

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Recent Progress on Synthesis, Characterization, and Applications of Metal Halide Perovskites@Metal Oxide

Substrate-independent three-dimensional polymer nanosheets induced by solution casting

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Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery

Abstract: The encapsulation of lead halide perovskite nanocrystals with an inert protective layer against moisture and the environment is a promising approach to overcome hinderances for their practical use in optoelectronic...

Cited by 74 publications

References 80 publications

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Recent Progress on Synthesis, Characterization, and Applications of Metal Halide Perovskites@Metal Oxide

Substrate-independent three-dimensional polymer nanosheets induced by solution casting

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Product

Resources

About

Highly luminescent biocompatible CsPbBr₃@SiO₂ core–shell nanoprobes for bioimaging and drug delivery