Highly loaded hydroxyapatite microsphere/ PLA porous scaffolds obtained by fused deposition modelling

Corcione, Carola Esposito; Gervaso, Francesca; Scalera, Francesca; Padmanabhan, Sanosh Kunjalukkal; Madaghiele, Marta; Montagna, Francesco; Sannino, Alessandro; Licciulli, Antonio; Maffezzoli, Alfonso

doi:10.1016/j.ceramint.2018.07.297

Cited by 193 publications

(121 citation statements)

References 30 publications

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“…Several studies have shown the improvement of mechanical properties and biological activity of PLA scaffolds generated by FDM [71,72]. Different fillers were used in compression [73] and flexural studies [74], but to the best of our knowledge, the mechanical properties of PLA-based nanocomposites were never investigated by tensile strength analysis. Overall, our findings indicate that GO is a promising filler for improving the mechanical properties of biopolymers made by FDM.…”

Section: Mechanical Properties Of the 3d Printed Nanocompositesmentioning

confidence: 99%

Development of new biocompatible 3D printed graphene oxide-based scaffolds

Belaid

Nagarajan

Teyssier

et al. 2020

Materials Science and Engineering: C

111

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The aim of this work was to develop a bioresorbable, biodegradable and biocompatible synthetic polymer with good mechanical properties for bone tissue engineering applications. Polylactic acid (PLA) scaffolds were generated by 3D printing using the fused deposition modelling method, and reinforced by incorporation of graphene oxide (GO). Morphological analysis by scanning electron microscopy indicated that the scaffold average pore size was between 400 and 500 μm. Topography imaging revealed a rougher surface upon GO incorporation (Sa = 5.8 μm for PLA scaffolds, and of 9.9 μm for PLA scaffolds with 0.2% GO), and contact angle measurements showed a transition from a hydrophobic surface (pure PLA scaffolds) to a hydrophilic surface after GO incorporation. PLA thermomechanical properties were enhanced by GO incorporation, as shown by the 70 °C increase of the degradation peak (thermal gravimetric analysis). However, GO incorporation did not change significantly the melting point assessed by differential scanning calorimetry. Physicochemical analyses by X-ray diffraction and Raman spectroscopy confirmed the filler presence. Tensile testing demonstrated that the mechanical properties were improved upon GO incorporation (30% increase of the Young's modulus with 0.3%GO). Cell viability, attachment, proliferation and differentiation assays using MG-63 osteosarcoma cells showed that PLA/ GO scaffolds were biocompatible and that they promoted cell proliferation and mineralization more efficiently than pure PLA scaffolds. In conclusion, this new 3D printed nanocomposite is a promising scaffold with adequate mechanical properties and cytocompatibility which may allow bone formation.

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Section: Mechanical Properties Of the 3d Printed Nanocompositesmentioning

confidence: 99%

Development of new biocompatible 3D printed graphene oxide-based scaffolds

Belaid

Nagarajan

Teyssier

et al. 2020

Materials Science and Engineering: C

111

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“…This encouraged the use of 3D printing (also known as rapid prototyping and solid freeform fabrication) technologies to allow the digital CAD design and digital manufacturing of tissue engineering scaffolds [1]. Figure 1 shows the schematic of CAD-designed scaffolds with interconnected macropores and examples of scaffolds fabricated by fused deposition modelling (FDM) [20][21][22][23][24][25][26][27][28][29][30] and stereolithography (SLA) [31][32][33][34][35][36][37][38][39][40][41][42][43][44]. In these scaffolds, the line width W and line spacing S (Figure 1(a)) can be easily tuned, thereby achieving controllable pore geometry, size, and interconnectivity.…”

Section: Origin Principle and Processes Of Low-temperature Depositimentioning

confidence: 99%

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Liu

Tong

et al. 2019

Journal of Nanomaterials

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Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

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“…One of the disadvantages of the proposed method is the relatively low content of HAp in the composite filament that reduces the mechanical strength of the 3D‐printed scaffold and its ability to produce bone tissue. Twin‐screw extruder mixing made it possible to increase the HAp content in the composite filament to 50%, however, the authors note stiffness decrease of 3D‐printed composite scaffolds 15 . Senatov et al fabricated PLLA/HAp composite filament with 15 wt% of HAp using a conical extruder 16 .…”

Section: Introductionmentioning

confidence: 99%

Highly filled poly(l‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

Dubinenko

Zinoviev

Bolbasov

et al. 2020

J of Applied Polymer Sci

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The designing of new biodegradable polymer composites is one of the most promising areas of modern orthopedics and regenerative surgery. At present, a number of methods have been proposed for designing and processing biodegradable polymer composites via various 3D printing technologies; however, the homogeneity of filler distribution together with mechanical properties of scaffolds made of such composites are far from those required for clinical use. In this study, the method for producing biodegradable composite material based on poly(l‐lactic acid) (PLLA) solution in organic solvent and hydroxyapatite (HAp) powder was proposed. The influence of HAp weight fraction and additional annealing on PLLA matrix crystallinity was investigated. It was shown that crystallinity of PLLA decreases from 58.84 ± 1.21 to 17.33 ± 1.69 as HAp weight fraction increased from 0 to 50 wt%. However, HAp filler promoted PLLA crystallites growth according to the X‐ray powder diffraction analysis. The results of nanoindentation showed Young's modulus values of the 3D‐printed scaffolds with 50 wt% of HAp at the level of human femur and tibia.

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Highly loaded hydroxyapatite microsphere/ PLA porous scaffolds obtained by fused deposition modelling

Cited by 193 publications

References 30 publications

Development of new biocompatible 3D printed graphene oxide-based scaffolds

Development of new biocompatible 3D printed graphene oxide-based scaffolds

Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

Highly filled poly(l‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

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